In This Issue
Cancer Discov October 1 2012 2 (10) 857-859; DOI:10.1158/2159-8290.CD-ITI12-10
Exomic sequencing of esophageal cancer subtypes identifi ed geographic disparities and differences in mutation frequencies, particularly of NOTCH genes.
NRP2 signaling inhibits IGF-IR expression via BMI-1 activity in advanced PTEN-null prostate cancer.
Increased HER2 expression confers resistance to EGFR tyrosine kinase inhibitors in non–small cell lung cancers with EGFR mutations.
Acquired resistance to EGFR inhibitors can occur through aberrant activation of ERK signaling via MAPK1 amplification or downregulation of ERK negative regulators.
A systematic analysis of secreted proteins shows that cancer cells can bypass oncogene addiction through ligand-mediated activation of multiple alternative pathways.