In This Issue
Cancer Discov August 1 2012 2 (8) 653-655; DOI:10.1158/2159-8290.CD-ITI12-08
Pancreatic ductal adenocarcinomas harboring KRAS mutations are dependent on RAF signaling and are sensitive to MEK inhibition.
Intratumoral injection of a STAT3 decoy oligonucleotide safely reduced target gene expression in a phase 0 clinical trial, and chemical modification may enable systemic delivery.
The formation of integrin β1-containing protrusions mediates FAK signaling to promote metastatic cell proliferation and colonization.
IDO orchestrates inflammation, vascularization, and immunosuppression to establish a protumorigenic environment in lung cancer and metastasis models.
miR-34a functions as a subtype-specific tumor suppressor in glioblastoma through targeted inhibition of SMAD4-regulated transcription.