Summary: Three recent studies, approaching the question from different angles and using different and/or overlapping models, provide compelling evidence for the involvement of tumor-infiltrating B cells in the initiation and progression of pancreatic ductal adenocarcinoma. These studies highlight the need for a better understanding of pancreatic tumor–immune system interactions and the immunologic mechanisms that promote or inhibit tumorigenesis, paving the way for better treatment strategies. Cancer Discov; 6(3); 230–2. ©2016 AACR.
See related article by Pylayeva-Gupta et al., p. 247.
See related article by Lee et al., p. 256.
See related article by Gunderson et al., p. 270.
- ©2016 American Association for Cancer Research.