Summary: Natural killer cells (NK) are commonly considered to be potent antitumor effector cells. The study by Gotthardt and colleagues challenges this concept and reveals that STAT5-deficient/inhibited NK cells induce angiogenesis and promote tumor progression. These unexpected findings shed new light on potential adverse effects of JAK–STAT inhibitors in the clinics. Cancer Discov; 6(4); 347–9. ©2016 AACR.
See related article by Gotthardt et al., p. 414.
- ©2016 American Association for Cancer Research.