In This Issue
Cancer Discov May 1 2016 6 (5) 461-463; DOI:10.1158/2159-8290.CD-ITI6-5
Four patients with NMC harboring BRD4–NUT fusion protein were compassionately treated with the BET inhibitor OTX015/MK-8628, resulting in two rapid responses and one disease stabilization, and two patients achieved extended overall survival post-diagnosis.
In a mouse model harboring FLT3 internal-tandem duplication, DNMT3A haploinsufficiency disrupts methylation of methylation-sensitive genes, resulting in fully penetrant acute myeloid leukemia.
An alternatively spliced form of the actin-associated protein MENA, MENAINV, associates with integrin α5β1 to induce migration toward high fibronectin concentrations and promote metastasis.
Glioblastoma tumor-initiating cells are a source of intratumor genetic heterogeneity due to chromosomal instability; however, further elevation of chromosomal instability results in reduced proliferation, self-renewal, and tumor-initiating properties in these cells.
Subsets of B cells in human HCC undergo TLR4/BCL6-mediated induction of PD-1 and promote IL10-dependent T-cell dysfunction upon interaction with PD-L1+ monocytes.