Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung Cancer

Shunsuke Kitajima; Elena Ivanova; Sujuan Guo; Ryohei Yoshida; Marco Campisi; Shriram K. Sundararaman; Shoichiro Tange; Yoichiro Mitsuishi; Tran C. Thai; Sayuri Masuda; Brandon P. Piel; Lynette M. Sholl; Paul T. Kirschmeier; Cloud P. Paweletz; Hideo Watanabe; Mamiko Yajima; David A. Barbie

doi:10.1158/2159-8290.CD-18-0689

Research Brief

Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung Cancer

Shunsuke Kitajima, Elena Ivanova, Sujuan Guo, Ryohei Yoshida, Marco Campisi, Shriram K. Sundararaman, Shoichiro Tange, Yoichiro Mitsuishi, Tran C. Thai, Sayuri Masuda, Brandon P. Piel, Lynette M. Sholl, Paul T. Kirschmeier, Cloud P. Paweletz, Hideo Watanabe, Mamiko Yajima and David A. Barbie

Shunsuke Kitajima

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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Elena Ivanova

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts.

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Sujuan Guo

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts.

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Ryohei Yoshida

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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Marco Campisi

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy.

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Shriram K. Sundararaman

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.University of Virginia School of Medicine, University of Virginia, Charlottesville, Virginia.

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ORCID record for Shriram K. Sundararaman

Shoichiro Tange

Department of Human Genetics, Graduate School of Biomedical Science, Tokushima University, Tokushima, Japan.

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Yoichiro Mitsuishi

Department of Respiratory Medicine, Graduate School of Medicine, Juntendo University, Tokyo, Japan.

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Tran C. Thai

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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Sayuri Masuda

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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Brandon P. Piel

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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Lynette M. Sholl

Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.

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Paul T. Kirschmeier

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts.

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Cloud P. Paweletz

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts.

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Hideo Watanabe

Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.

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Mamiko Yajima

MCB Department, Brown University, Providence, Rhode Island.

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David A. Barbie

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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For correspondence: dbarbie@partners.org

DOI: 10.1158/2159-8290.CD-18-0689 Published January 2019

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January 2019
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Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung Cancer