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Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression

Maria Rusan, Kapsok Li, Yvonne Li, Camilla L. Christensen, Brian J. Abraham, Nicholas Kwiatkowski, Kevin A. Buczkowski, Bruno Bockorny, Ting Chen, Shuai Li, Kevin Rhee, Haikuo Zhang, Wankun Chen, Hideki Terai, Tiffany Tavares, Alan L. Leggett, Tianxia Li, Yichen Wang, Tinghu Zhang, Tae-Jung Kim, Sook-Hee Hong, Neermala Poudel-Neupane, Michael Silkes, Tenny Mudianto, Li Tan, Takeshi Shimamura, Matthew Meyerson, Adam J. Bass, Hideo Watanabe, Nathanael S. Gray, Richard A. Young, Kwok-Kin Wong and Peter S. Hammerman
Maria Rusan
Department of Medical Oncology, Dana-Farber Cancer Institute, ­Boston, Massachusetts.Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.Cancer Program, Broad Institute of Harvard and ­Massachusetts Institute of Technology, Cambridge, Massachusetts.
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Kapsok Li
Department of Medical Oncology, Dana-Farber Cancer Institute, ­Boston, Massachusetts.Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.
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Yvonne Li
Department of Medical Oncology, Dana-Farber Cancer Institute, ­Boston, Massachusetts.Cancer Program, Broad Institute of Harvard and ­Massachusetts Institute of Technology, Cambridge, Massachusetts.
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Camilla L. Christensen
Department of Medical Oncology, Dana-Farber Cancer Institute, ­Boston, Massachusetts.
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Brian J. Abraham
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts.
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Nicholas Kwiatkowski
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts.Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts.
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Kevin A. Buczkowski
Department of Medical Oncology, Dana-Farber Cancer Institute, ­Boston, Massachusetts.
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Bruno Bockorny
Department of Medical Oncology, Dana-Farber Cancer Institute, ­Boston, Massachusetts.Cancer Program, Broad Institute of Harvard and ­Massachusetts Institute of Technology, Cambridge, Massachusetts.Division of Hematology and Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
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Ting Chen
Department of Medical Oncology, Dana-Farber Cancer Institute, ­Boston, Massachusetts.
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Shuai Li
Department of Medical Oncology, Dana-Farber Cancer Institute, ­Boston, Massachusetts.
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Kevin Rhee
Department of Medical Oncology, Dana-Farber Cancer Institute, ­Boston, Massachusetts.
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Haikuo Zhang
Department of Medical Oncology, Dana-Farber Cancer Institute, ­Boston, Massachusetts.
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Wankun Chen
Department of Medical Oncology, Dana-Farber Cancer Institute, ­Boston, Massachusetts.Department of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai, China.Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
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Hideki Terai
Department of Medical Oncology, Dana-Farber Cancer Institute, ­Boston, Massachusetts.
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Tiffany Tavares
Department of Medical Oncology, Dana-Farber Cancer Institute, ­Boston, Massachusetts.
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Alan L. Leggett
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Tianxia Li
Department of Medical Oncology, Dana-Farber Cancer Institute, ­Boston, Massachusetts.
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Yichen Wang
Department of Medical Oncology, Dana-Farber Cancer Institute, ­Boston, Massachusetts.
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Tinghu Zhang
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts.
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Tae-Jung Kim
Department of Medical Oncology, Dana-Farber Cancer Institute, ­Boston, Massachusetts.Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
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Sook-Hee Hong
Department of Medical Oncology, Dana-Farber Cancer Institute, ­Boston, Massachusetts.
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Neermala Poudel-Neupane
Department of Medical Oncology, Dana-Farber Cancer Institute, ­Boston, Massachusetts.
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Michael Silkes
Department of Medical Oncology, Dana-Farber Cancer Institute, ­Boston, Massachusetts.
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Tenny Mudianto
Department of Medical Oncology, Dana-Farber Cancer Institute, ­Boston, Massachusetts.
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Li Tan
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts.
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Takeshi Shimamura
Molecular Pharmacology and Therapeutics, Oncology Research Institute, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois.
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Matthew Meyerson
Department of Medical Oncology, Dana-Farber Cancer Institute, ­Boston, Massachusetts.Cancer Program, Broad Institute of Harvard and ­Massachusetts Institute of Technology, Cambridge, Massachusetts.
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Adam J. Bass
Department of Medical Oncology, Dana-Farber Cancer Institute, ­Boston, Massachusetts.Cancer Program, Broad Institute of Harvard and ­Massachusetts Institute of Technology, Cambridge, Massachusetts.Departments of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts.
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Hideo Watanabe
Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
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Nathanael S. Gray
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts.
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Richard A. Young
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts.Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts.
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Kwok-Kin Wong
Laura & Isaac Perlmutter Cancer Center, NYU Langone Medical Center, New York, New York.
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Peter S. Hammerman
Department of Medical Oncology, Dana-Farber Cancer Institute, ­Boston, Massachusetts.Cancer Program, Broad Institute of Harvard and ­Massachusetts Institute of Technology, Cambridge, Massachusetts.Novartis Institutes of Biomedical Research, ­Cambridge, Massachusetts.
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  • For correspondence: peter.hammerman@novartis.com
DOI: 10.1158/2159-8290.CD-17-0461
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Article Information

DOI 
https://doi.org/10.1158/2159-8290.CD-17-0461
PubMed 
29054992

Published By 
American Association for Cancer Research
Print ISSN 
2159-8274
Online ISSN 
2159-8290
History 
  • Received May 1, 2017
  • Revision received October 2, 2017
  • Accepted October 17, 2017
  • Published first October 20, 2017.

Article Versions

  • Previous version (October 20, 2017 - 05:51).
  • You are currently viewing a Previous version of this article (December 20, 2017 - 07:51).
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Copyright & Usage 
©2017 American Association for Cancer Research.

Author Information

  1. Maria Rusan1,2,3,
  2. Kapsok Li1,4,
  3. Yvonne Li1,3,
  4. Camilla L. Christensen1,
  5. Brian J. Abraham5,
  6. Nicholas Kwiatkowski5,6,7,
  7. Kevin A. Buczkowski1,
  8. Bruno Bockorny1,3,8,
  9. Ting Chen1,
  10. Shuai Li1,
  11. Kevin Rhee1,
  12. Haikuo Zhang1,
  13. Wankun Chen1,9,10,
  14. Hideki Terai1,
  15. Tiffany Tavares1,
  16. Alan L. Leggett6,
  17. Tianxia Li1,
  18. Yichen Wang1,
  19. Tinghu Zhang6,7,
  20. Tae-Jung Kim1,11,
  21. Sook-Hee Hong1,
  22. Neermala Poudel-Neupane1,
  23. Michael Silkes1,
  24. Tenny Mudianto1,
  25. Li Tan6,7,
  26. Takeshi Shimamura12,
  27. Matthew Meyerson1,3,
  28. Adam J. Bass1,3,13,
  29. Hideo Watanabe14,
  30. Nathanael S. Gray6,7,
  31. Richard A. Young5,15,
  32. Kwok-Kin Wong16 and
  33. Peter S. Hammerman1,3,17,*
  1. 1Department of Medical Oncology, Dana-Farber Cancer Institute, ­Boston, Massachusetts.
  2. 2Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
  3. 3Cancer Program, Broad Institute of Harvard and ­Massachusetts Institute of Technology, Cambridge, Massachusetts.
  4. 4Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.
  5. 5Whitehead Institute for Biomedical Research, Cambridge, Massachusetts.
  6. 6Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  7. 7Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts.
  8. 8Division of Hematology and Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
  9. 9Department of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai, China.
  10. 10Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
  11. 11Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  12. 12Molecular Pharmacology and Therapeutics, Oncology Research Institute, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois.
  13. 13Departments of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts.
  14. 14Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
  15. 15Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts.
  16. 16Laura & Isaac Perlmutter Cancer Center, NYU Langone Medical Center, New York, New York.
  17. 17Novartis Institutes of Biomedical Research, ­Cambridge, Massachusetts.
  1. ↵*Corresponding Author:
    Peter S. Hammerman, Novartis Institutes of ­Biomedical Research, Cambridge, MA 02139. Phone: 617-632-6335; Fax: 617-582-7880; E-mail: peter.hammerman{at}novartis.com

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Published OnlineFirst December 20, 2017
doi: 10.1158/2159-8290.CD-17-0461

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Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression
Maria Rusan, Kapsok Li, Yvonne Li, Camilla L. Christensen, Brian J. Abraham, Nicholas Kwiatkowski, Kevin A. Buczkowski, Bruno Bockorny, Ting Chen, Shuai Li, Kevin Rhee, Haikuo Zhang, Wankun Chen, Hideki Terai, Tiffany Tavares, Alan L. Leggett, Tianxia Li, Yichen Wang, Tinghu Zhang, Tae-Jung Kim, Sook-Hee Hong, Neermala Poudel-Neupane, Michael Silkes, Tenny Mudianto, Li Tan, Takeshi Shimamura, Matthew Meyerson, Adam J. Bass, Hideo Watanabe, Nathanael S. Gray, Richard A. Young, Kwok-Kin Wong and Peter S. Hammerman
Cancer Discov December 20 2017 DOI: 10.1158/2159-8290.CD-17-0461

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Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression
Maria Rusan, Kapsok Li, Yvonne Li, Camilla L. Christensen, Brian J. Abraham, Nicholas Kwiatkowski, Kevin A. Buczkowski, Bruno Bockorny, Ting Chen, Shuai Li, Kevin Rhee, Haikuo Zhang, Wankun Chen, Hideki Terai, Tiffany Tavares, Alan L. Leggett, Tianxia Li, Yichen Wang, Tinghu Zhang, Tae-Jung Kim, Sook-Hee Hong, Neermala Poudel-Neupane, Michael Silkes, Tenny Mudianto, Li Tan, Takeshi Shimamura, Matthew Meyerson, Adam J. Bass, Hideo Watanabe, Nathanael S. Gray, Richard A. Young, Kwok-Kin Wong and Peter S. Hammerman
Cancer Discov December 20 2017 DOI: 10.1158/2159-8290.CD-17-0461
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