Table 1.

Molecular classification for APL and its implications for treatment and therapy

Aberrant genesTranslocationsResponse to chemotherapyResponse to RA treatmentRisk of treatment failure
PML-RARαt(15;17)GoodGoodLow/intermediate
PLZF-RARαt(11;17)PoorPoorHigh
NPM-RARαt(5;17)GoodGoodLow/intermediate
NuMA-RARαt(11;17)GoodGoodLow/intermediate
STAT5b-RARαt(17;17) Poor