Table 2.

Grade 3 and 4 toxicities

ToxicitiesGrade 3
Cycle 1
n = 45
Grade 3
Cycle ≥2
n = 32
Grade 4
Cycle 1
n = 45
Grade 4
Cycle ≥2
n = 32
n%n%n%n%
Hematologic toxicities
 Anemia36.713.1
 Leukopenia12.226.312.2
 Lymphopenia48.939.412.2
 Neutropenia39.412.2
 Thrombocytopenia12.2
Gastrointestinal symptoms
 Abdominal pain12.2
 Constipation12.213.1
 Diarrhea12.2
 Nausea24.4
 Vomiting12.2
Electrolyte disturbances
 Hypokalemia13.1
 Hyponatremia36.7
Generalized symptoms
 Anorexia24.4
 Dyspnea12.2
 Fatigue24.4412.5
 Weakness13.1