Table 1.

Summary of clinical, tissue, and study characteristics

Total # (% of total)Subset characteristics
Patients44MaleFemaleBoth
Patient Counts311344
Median age (range)59 (29–84)53 (38–70)59 (29–84)
Median PFS (d)149183145
Median BOR−47%−63%−53%
Disease stage
lllc112
M1a6410
M1b123
M1c23629
Tumor biopsies100Baseline biopsies29 (29%)
DP biopsies71 (71%)
DP biopsies with patient-matched baseline biopsies55 (77% of DPs)
Patients with multiple DP biopsies16 (36%)DPs/patient = 211 (69%)
DPs/patient = 34 (25%)
DPs/patient > 31 (6%)
Patients with WES data from normal, baseline and DP tissues21 (48%)Normal tissues21 (24%)
Baseline tumors22 (25%)
DP tumors44 (51%)
Total samples with WES87

Abbreviation: WES, whole-exome sequence.