Table 1.

List of genes implicated in the metastatic cascade that are direct or indirect targets of p53

GeneFunctionActivated or repressed by p53Direct or indirect p53 targetReference
KAI-1/CD82Suppresses cell migrationActivatedDirect(7)
XEDARSuppresses cell adhesion and migrationActivatedDirect(12)
miR-200cSuppresses EMTActivatedDirect(14)
MMP2Interactions with ECMActivatedDirect(28)
DDR1Interactions with ECMActivatedDirect(30)
PAI-1Inhibits plasminogen and hence fibrinolysisActivatedDirect(24)
miR-34Suppresses cell migrationActivatedDirect(77)
MaspinInteractions with ECMActivatedDirect(25)
PCDH7Cell migrationRepressedDirect(3)
VimentinMesenchymal markerRepressedDirect(3)
CD44EMT, stemnessRepressedDirect(19)
NANOGStemnessRepressedDirect(20)
CXCR4Chemotaxis, cell migrationRepressedDirect(60)
FAKAdhesion, motility, metastasis, survival signalingRepressedDirect(78)
E-cadherinMaintains epithelial integrityActivatedIndirect(17)
CTGFCell migration and adhesion to ECMActivatedIndirect(79)
ThrombospondinInteractions with ECMActivatedIndirect(80)
CaldesmonInteractions with ECMActivatedIndirect(37)
SNAI1EMTRepressedIndirect(16)
SNAI2/SLUGEMTDegradedIndirect(17)
MMP9Interactions with ECMRepressedIndirect(35)
MMP1Interactions with ECMRepressedIndirect(29)
SPARCCell migration (negative regulator)RepressedIndirect(59)
FibronectinInteractions with ECMRepressedIndirect(36)