Table 1.

Comparative summary of melanomagenesis and macrometastasis in LSL-Ras–driven models

GenotypeTumors/treated mice, %Median tumor latency, wksMacrometastasis
Tp1/24 (4.1%)>80None
TpN12D/12D1/29 (3.4%)>80None
TpN61R/61R14/20 (70%)26.3None
TpK12D/WT16/21 (76%)36.3None
TpLN61R/61R17/20 (85%)22.15/14 (36%)