Table 2.

Binding affinities of RAS·mantGMPPNP to PI3Kγ and RAF-RBD

mantGMPPNP binding
RAS mutantKd to bRaf-RBD (µmol/L)Kd to PI3K (µmol/L)
NRASWT0.07 ± 0.032.2 ± 0.4
NRASG12D0.08 ± 0.041.8 ± 0.5
NRASQ61R0.28 ± 0.042.7 ± 1.2
KRASG12D0.06 ± 0.032.5 ± 0.8