Table 2.

Genes with three or more private heterozygous PTVs in unrelated patients with FPC

GeneNumber of heterozygous PTVs in FPC kindredComment
ATM19FPC susceptibility gene; cancer driver gene; DNA repair gene
TET29Cancer driver gene
DNMT3A7Cancer driver gene
POLN6DNA repair gene
POLQ6DNA repair gene
ASXL15Cancer driver gene
BRCA25Cancer driver gene; DNA repair gene
PALB25FPC susceptibility gene; DNA repair gene
CDKN2A4FPC susceptibility gene; cancer driver gene; DNA repair gene
FANCG4DNA repair gene
BUB1B3DNA repair gene
ESCO23DNA repair gene
FANCC3DNA repair gene
FANCM3DNA repair gene
MSH43DNA repair gene
RAD54L3DNA repair gene