Table 1.

Clinical characteristics of the tumor biopsies sequenced in the study

CharacteristicsTotal, N = 929ESR1 WT, N = 834ESR1 mutated, N = 95P
Receptor subtype
 HR+/HER2139546 (86.5%)85 (13.5%)
 HR+/HER2+126116 (92.1%)10 (7.9%)
 HR/HER2+5050 (100%)0 (0%)
 Triple negative122122 (100%)0 (0%)<0.00001
Histology
 Invasive ductal698626 (89.7%)72 (10.3%)
 Invasive lobular141121 (85.8%)20 (14.2%)
 Mixed ductal/lobular4242 (100%)0 (0%)
 Carcinoma NOS3835 (92.1%)3 (7.9%)
 Other1010 (100%)0 (0%)0.09
Site of biopsy
 Primary313302 (96.5%)11 (3.5%)
 Metastasis616532 (86.4%)84 (13.6%)<0.00001
Metastatic site biopsied (N = 616)
 Liver160126 (78.8%)34 (21.3%)
 Lymph node9690 (93.8%)6 (6.3%)
 Bone8979 (88.8%)10 (11.2%)
 Chest wall5346 (86.8%)7 (13.2%)
 Lung4945 (91.8%)4 (8.2%)
 Brain2424 (100%)0 (0%)
 Soft tissue2522 (88%)3 (12%)
 Ovary2221 (95.5%)1 (4.5%)
 Skin2421 (87.5%)3 (12.5%)
 Pleura2320 (87%)3 (13%)
 Other5138 (74.5%)13 (25.5%)0.0017
  • Abbreviation: NOS, not otherwise specified.