Table 1.

Genetic manipulation of CD38 on tumor cells dramatically changes the tumor immune microenvironment

Immune profileLLC-JSP tumors531LN3 tumors
CD38 knockdownCD38 overexpressionCD38 knockdownCD38 overexpression
ScrshCD38P valueVectorCD38P valueScrshCD38P valueVectorCD38P value
% of CD8+ T cells9.23 ± 1.3916.36 ± 0.71(0.0018)10.41 ± 0.955.90 ± 0.92(0.0093)12.02 ± 1.5718.08 ± 0.89(0.0100)14.60 ± 1.317.91 ± 1.02(0.0037)
% of PD-1+TIM3+ CD8+ T cells23.44 ± 1.1915.00 ± 1.56(0.0026)20.90 ± 1.6330.78 ± 2.77(0.0153)19.26 ± 1.5911.87 ± 1.41(0.0084)9.88 ± 1.9852.36 ± 2.18(0.0001)
% of IFNγ+CD8+ T cells7.62 ± 0.7618.55 ± 0.84(< 0.0001)9.55 ± 0.655.09 ± 0.13(0.0005)12.80 ± 0.4421.55 ± 0.82(< 0.0001)13.58 ± 0.494.14 ± 0.28(0.0001)