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Clinical Research Slows as COVID19 Surges - read the just published Cancer Discovery News article!

From the Current Issue

  • Research Articles | Free Article
    Characteristics and Outcome of AKT1E17K-Mutant Breast Cancer Defined through AACR Project GENIE, a Clinicogenomic Registry
    Lillian M. Smyth, Qin Zhou, Bastien Nguyen, Celeste Yu, Eva M. Lepisto, Monica Arnedos, Michael J. Hasset, Michele L. Lenoue-Newton, Natalie Blauvelt, Semih Dogan, Christine M. Micheel, Chetna Wathoo, Hugo Horlings, Jan Hudecek, Benjamin E. Gross, Ritika Kundra, Shawn M. Sweeney, JianJiong Gao, Nikolaus Schultz, Andrew Zarski, Stuart M. Gardos, Jocelyn Lee, Seth Sheffler-Collins, Ben H. Park, Charles L. Sawyers, Fabrice André, Mia Levy, Funda Meric-Bernstam, Philippe L. Bedard, Alexia Iasonos, Deborah Schrag and David M. Hyman; for the AACR Project GENIE Consortium
    Cancer Discov April 1 2020 10 (4) 526-535; DOI:10.1158/2159-8290.CD-19-1209

    Data from AACR Project GENIE were used to investigate the effects of the rare AKT1E17K mutation in ER+ breast cancer, showing the challenges and advantages of using this type of real-world evidence.

  • Research Articles
    Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Patients with Acute Myeloid Leukemia
    Shanshan Pei, Daniel A. Pollyea, Annika Gustafson, Brett M. Stevens, Mohammad Minhajuddin, Rui Fu, Kent A. Riemondy, Austin E. Gillen, Ryan M. Sheridan, Jihye Kim, James C. Costello, Maria L. Amaya, Anagha Inguva, Amanda Winters, Haobin Ye, Anna Krug, Courtney L. Jones, Biniam Adane, Nabilah Khan, Jessica Ponder, Jeffrey Schowinsky, Diana Abbott, Andrew Hammes, Jason R. Myers, John M. Ashton, Travis Nemkov, Angelo D'Alessandro, Jonathan A. Gutman, Haley E. Ramsey, Michael R. Savona, Clayton A. Smith and Craig T. Jordan
    Cancer Discov April 1 2020 10 (4) 536-551; DOI:10.1158/2159-8290.CD-19-0710

    Compared with less differentiated acute myeloid leukemia (AML), monocytic AML is more resistant to venetoclax-based therapy, a phenomenon that may be attributable to dedifferentiation of preexisting monocytic subclones.

  • Research Articles | AuthorChoice
    MYC Instructs and Maintains Pancreatic Adenocarcinoma Phenotype
    Nicole M. Sodir, Roderik M. Kortlever, Valentin J.A. Barthet, Tania Campos, Luca Pellegrinet, Steven Kupczak, Panayiotis Anastasiou, Lamorna Brown Swigart, Laura Soucek, Mark J. Arends, Trevor D. Littlewood and Gerard I. Evan
    Cancer Discov April 1 2020 10 (4) 588-607; DOI:10.1158/2159-8290.CD-19-0435

    In a mouse model of mutant Kras–driven pancreatic ductal adenocarcinoma (PDAC), Myc activation was required for progression to PDAC, whereas Myc deactivation caused rapid regression of even established PDACs.

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