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Murray et al., as well as Hollstein et. al, showed that the tumorigenic effects of disruption of the kinase LKB1, frequently mutated in lung cancer, are mediated by its downstream kinases SIK1 and SIK3. Find out more in the articles.
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Just Published!
The KRASG12C Inhibitor, MRTX849, Provides Insight Toward Therapeutic Susceptibility of KRAS Mutant Cancers in Mouse Models and Patients. James G. Christensen, et al.
Research Article
First-in-Human Phase I Study of Fisogatinib (BLU-554) Validates Aberrant Fibroblast Growth Factor 19 Signaling as a Driver Event in Hepatocellular Carcinoma, Richard D Kim, et al.
Research Brief
Acquired On-Target Clinical Resistance Validates FGFR4 as a Driver of Hepatocellular Carcinoma, Megan A. Hatlen, et al.

From the Current Issue

Research Brief | AuthorChoice

Infiltrating Myeloid Cells Drive Osteosarcoma Progression via GRM4 Regulation of IL23

Maya Kansara, Kristian Thomson, Puiyi Pang, Aurelie Dutour, Lisa Mirabello, Francine Acher, Jean-Philippe Pin, Elizabeth G. Demicco, Juming Yan, Michele W.L. Teng, Mark J. Smyth and David M. Thomas

Cancer Discov November 1 2019 9 (11) 1511-1519; DOI:10.1158/2159-8290.CD-19-0154

Glutamate metabotropic receptor 4 regulates the expression of the inflammatory cytokine IL23 in mice, leading to a restriction of osteosarcoma development that can be therapeutically targeted.
Research Articles

CDK7 Inhibition Suppresses Castration-Resistant Prostate Cancer through MED1 Inactivation

Reyaz ur Rasool, Ramakrishnan Natesan, Qu Deng, Shweta Aras, Priti Lal, Samuel Sander Effron, Erick Mitchell-Velasquez, Jessica M. Posimo, Shannon Carskadon, Sylvan C. Baca, Mark M. Pomerantz, Javed Siddiqui, Lauren E. Schwartz, Daniel J. Lee, Nallasivam Palanisamy, Goutham Narla, Robert B. Den, Matthew L. Freedman, Donita C. Brady and Irfan A. Asangani

Cancer Discov November 1 2019 9 (11) 1538-1555; DOI:10.1158/2159-8290.CD-19-0189

Phosphorylation of MED1 by the cyclin-dependent kinase CDK7 leads to an interaction between MED1 and AR, and CDK7 inhibition causes tumor regression in a mouse model of castration-resistant prostate cancer.
Research Articles

Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock

Zhen Dong, Guoxin Zhang, Meng Qu, Ryan C. Gimple, Qiulian Wu, Zhixin Qiu, Briana C. Prager, Xiuxing Wang, Leo J.Y. Kim, Andrew R. Morton, Deobrat Dixit, Wenchao Zhou, Haidong Huang, Bin Li, Zhe Zhu, Shideng Bao, Stephen C. Mack, Lukas Chavez, Steve A. Kay and Jeremy N. Rich

Cancer Discov November 1 2019 9 (11) 1556-1573; DOI:10.1158/2159-8290.CD-19-0215

The core circadian proteins BMAL1 and CLOCK are essential to the maintenance of glioblastoma stem cells, and genetic or pharmacologic inhibition of BMAL1 or CLOCK increased survival in a mouse model of glioblastoma.

Recent Reviews

Review

Altered RNA Processing in Cancer Pathogenesis and Therapy

Esther A. Obeng, Connor Stewart and Omar Abdel-Wahab

Cancer Discov November 1 2019 9 (11) 1493-1510; DOI:10.1158/2159-8290.CD-19-0399
Mini Review

Tumor Microenvironment Dynamics in Clear-Cell Renal Cell Carcinoma

Lynda Vuong, Ritesh R. Kotecha, Martin H. Voss and A. Ari Hakimi

Cancer Discov October 1 2019 9 (10) 1349-1357; DOI:10.1158/2159-8290.CD-19-0499
Review

Targeting Autophagy in Cancer: Recent Advances and Future Directions

Ravi K. Amaravadi, Alec C. Kimmelman and Jayanta Debnath

Cancer Discov September 1 2019 9 (9) 1167-1181; DOI:10.1158/2159-8290.CD-19-0292
Review

The Metabolic Basis of Kidney Cancer

W. Marston Linehan, Laura S. Schmidt, Daniel R. Crooks, Darmood Wei, Ramaprasad Srinivasan, Martin Lang and Christopher J. Ricketts

Cancer Discov August 1 2019 9 (8) 1006-1021; DOI:10.1158/2159-8290.CD-18-1354

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