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Read, Science in Society: Rethinking Cancer Clinical Trial Conduct Induced by COVID-19: An Academic Center, Industry, Government, and Regulatory Agency Perspective.

From the Current Issue

  • Research Articles
    Genetic Determinants of EGFR-Driven Lung Cancer Growth and Therapeutic Response In Vivo
    Giorgia Foggetti, Chuan Li, Hongchen Cai, Jessica A. Hellyer, Wen-Yang Lin, Deborah Ayeni, Katherine Hastings, Jungmin Choi, Anna Wurtz, Laura Andrejka, Dylan G. Maghini, Nicholas Rashleigh, Stellar Levy, Robert Homer, Scott N. Gettinger, Maximilian Diehn, Heather A. Wakelee, Dmitri A. Petrov, Monte M. Winslow and Katerina Politi
    Cancer Discov July 1 2021 11 (7) 1736-1753; DOI:10.1158/2159-8290.CD-20-1385

    Some inactivating mutations in genes known to act as tumor suppressors in Kras-driven mouse lung adenocarcinoma models had the opposite effect in Egfr-driven lung cancer models, instead restricting tumor growth.

  • Research Articles
    A Functional Taxonomy of Tumor Suppression in Oncogenic KRAS–Driven Lung Cancer
    Hongchen Cai, Su Kit Chew, Chuan Li, Min K. Tsai, Laura Andrejka, Christopher W. Murray, Nicholas W. Hughes, Emily G. Shuldiner, Emily L. Ashkin, Rui Tang, King L. Hung, Leo C. Chen, Shi Ya C. Lee, Maryam Yousefi, Wen-Yang Lin, Christian A. Kunder, Le Cong, Christopher D. McFarland, Dmitri A. Petrov, Charles Swanton and Monte M. Winslow
    Cancer Discov July 1 2021 11 (7) 1754-1773; DOI:10.1158/2159-8290.CD-20-1325

    An innovative in vivo screening technique revealed that inactivation of various tumor suppressor genes had dramatically different effects on cancer development and progression in oncogenic Kras–driven mouse models of lung cancer.

  • Research Articles
    Bacterial-Driven Inflammation and Mutant BRAF Expression Combine to Promote Murine Colon Tumorigenesis That Is Sensitive to Immune Checkpoint Therapy
    Christina E. DeStefano Shields, James R. White, Liam Chung, Alyssa Wenzel, Jessica L. Hicks, Ada J. Tam, June L. Chan, Christine M. Dejea, Hongni Fan, John Michel, Ashley R. Maiuri, Shruthi Sriramkumar, Ram Podicheti, Douglas B. Rusch, Hao Wang, Angelo M. De Marzo, Sepideh Besharati, Robert A. Anders, Stephen B. Baylin, Heather M. O'Hagan, Franck Housseau and Cynthia L. Sears
    Cancer Discov July 1 2021 11 (7) 1792-1807; DOI:10.1158/2159-8290.CD-20-0770

    In a mouse model of colorectal cancer driven by enterotoxigenic bacteria, expression of oncogenic human BRAFV600E generated tumors that recapitulated the biology of human BRAFV600E-mutant tumors and were sensitive to anti–PD-L1 treatment.

  • Research Articles
    Macropinocytosis in Cancer-Associated Fibroblasts Is Dependent on CaMKK2/ARHGEF2 Signaling and Functions to Support Tumor and Stromal Cell Fitness
    Yijuan Zhang, M. Victoria Recouvreux, Michael Jung, Koen M.O. Galenkamp, Yunbo Li, Olga Zagnitko, David A. Scott, Andrew M. Lowy and Cosimo Commisso
    Cancer Discov July 1 2021 11 (7) 1808-1825; DOI:10.1158/2159-8290.CD-20-0119

    Under the glutamine-limiting conditions common in pancreatic ductal adenocarcinomas, cancer-associated fibroblasts activated macropinocytosis to engulf extracellular materials, enabling them to survive as well as secrete glutamine for use by tumor cells.

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