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Cancer Discovery

Cancer Discovery

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The AACR remains fully committed to supporting publishing operations throughout this challenging time, while still remaining flexible and supportive of the author, reviewer, and editor communities that we serve. If you have any questions or concerns, please reach out to a member of the AACR publishing staff.
Please visit the COVID-19 & Cancer Resource Center where COVID-related content is freely available.

 

Read, Science in Society: Priority COVID-19 vaccination for patients with cancer while vaccine supply is limited

  • Current cover from Cancer Discovery
    Read the January issue!
    About the cover: The study by Sakuma et al suggests that, contrary to the common assumption, targeting the NPC may be a viable strategy for anticancer therapies. Find out more in the article.
  • The Cancer Discovery News website
    Cancer Discovery News website
    Keep up with findings in the cancer research field via our website, highlighting must-read industry news, and on Twitter @CD_AACR!
  • In Focus
    In Focus
    Read: Cancer Grand Challenges: Embarking on a New Era of Discovery, Iain Foulkes and Norman E. Sharpless.
  • Research Article
    Research Article
    Read: Poor Survival and Differential Impact of Genetic Features of Black Patients with Acute Myeloid Leukemia, Bhavana Bhatnagar, et al.
  • Research Briefs
    Research Briefs
    Read: Genetic ancestry contributes to somatic mutations in lung cancers from admixed Latin American populations, Jian Carrot-Zhang, et al.
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From the Current Issue

  • Research Articles | AuthorChoice
    First-in-Human Trial of the Oral Ataxia Telangiectasia and RAD3-Related (ATR) Inhibitor BAY 1895344 in Patients with Advanced Solid Tumors
    Timothy A. Yap, David S.P. Tan, Angelika Terbuch, Reece Caldwell, Christina Guo, Boon Cher Goh, Valerie Heong, Noor R. Md. Haris, Saira Bashir, Yvette Drew, David S. Hong, Funda Meric-Bernstam, Gary Wilkinson, Joseph Hreiki, Antje M. Wengner, Friedhelm Bladt, Andreas Schlicker, Matthias Ludwig, Yinghui Zhou, Li Liu, Sonal Bordia, Ruth Plummer, Eleni Lagkadinou and Johann S. de Bono
    Cancer Discov January 1 2021 11 (1) 80-91; DOI:10.1158/2159-8290.CD-20-0868

    In a phase I trial, the ATR inhibitor BAY 1895344 showed preliminary evidence of efficacy against advanced solid tumors, particularly those with low ATM protein levels and/or ATM mutations.

  • Research Articles
    Resistance to Avapritinib in PDGFRA-Driven GIST Is Caused by Secondary Mutations in the PDGFRA Kinase Domain
    Susanne Grunewald, Lillian R. Klug, Thomas Mühlenberg, Jonas Lategahn, Johanna Falkenhorst, Ajia Town, Christiane Ehrt, Eva Wardelmann, Wolfgang Hartmann, Hans-Ulrich Schildhaus, Juergen Treckmann, Jonathan A. Fletcher, Sascha Jung, Paul Czodrowski, Stephen Miller, Oleg Schmidt-Kittler, Daniel Rauh, Michael C. Heinrich and Sebastian Bauer
    Cancer Discov January 1 2021 11 (1) 108-125; DOI:10.1158/2159-8290.CD-20-0487

    PDGFRA-mutant gastrointestinal stromal tumors that develop resistance to PDGFRA inhibition harbored secondary mutations in the PDGFRA kinase domain, and these tumors were still dependent on oncogenic PDGFRA signaling.

  • Research Articles | AuthorChoice
    BI-3406, a Potent and Selective SOS1–KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition
    Marco H. Hofmann, Michael Gmachl, Juergen Ramharter, Fabio Savarese, Daniel Gerlach, Joseph R. Marszalek, Michael P. Sanderson, Dirk Kessler, Francesca Trapani, Heribert Arnhof, Klaus Rumpel, Dana-Adriana Botesteanu, Peter Ettmayer, Thomas Gerstberger, Christiane Kofink, Tobias Wunberg, Andreas Zoephel, Szu-Chin Fu, Jessica L. Teh, Jark Böttcher, Nikolai Pototschnig, Franziska Schachinger, Katharina Schipany, Simone Lieb, Christopher P. Vellano, Jonathan C. O'Connell, Rachel L. Mendes, Jurgen Moll, Mark Petronczki, Timothy P. Heffernan, Mark Pearson, Darryl B. McConnell and Norbert Kraut
    Cancer Discov January 1 2021 11 (1) 142-157; DOI:10.1158/2159-8290.CD-20-0142

    A novel small-molecule drug, BI-3406, was used to block interactions between KRAS and the guanine exchange factor SOS1, hindering GTP binding by KRAS and thus reducing its activity to prevent tumor cell growth in vitro and in vivo.

  • Research Articles | AuthorChoice
    Antibody to CD137 Activated by Extracellular Adenosine Triphosphate Is Tumor Selective and Broadly Effective In Vivo without Systemic Immune Activation
    Mika Kamata-Sakurai, Yoshinori Narita, Yuji Hori, Takayuki Nemoto, Ryo Uchikawa, Masaki Honda, Naoka Hironiwa, Kenji Taniguchi, Meiri Shida-Kawazoe, Shoichi Metsugi, Taro Miyazaki, Naoko A. Wada, Yuki Ohte, Shun Shimizu, Hirofumi Mikami, Tatsuhiko Tachibana, Natsuki Ono, Kenji Adachi, Tetsushi Sakiyama, Tomochika Matsushita, Shojiro Kadono, Shun-ichiro Komatsu, Akihisa Sakamoto, Sayuri Horikawa, Ayano Hirako, Koki Hamada, Sotaro Naoi, Nasa Savory, Yasuko Satoh, Motohiko Sato, Yuki Noguchi, Junko Shinozuka, Haruka Kuroi, Ami Ito, Tetsuya Wakabayashi, Masaki Kamimura, Fumihisa Isomura, Yasushi Tomii, Noriaki Sawada, Atsuhiko Kato, Otoya Ueda, Yoshito Nakanishi, Mika Endo, Kou-ichi Jishage, Yoshiki Kawabe, Takehisa Kitazawa and Tomoyuki Igawa
    Cancer Discov January 1 2021 11 (1) 158-175; DOI:10.1158/2159-8290.CD-20-0328

    An extracellular ATP–activated agonistic antibody to CD137, which promotes T-cell survival and proliferation, showed antitumor efficacy in multiple in vivo models, causing T-cell activation within tumors without off-target toxicity.


Recent Reviews

  • Reviews
    Tumor-Infiltrating Natural Killer Cells
    Beatriz Cózar, Marco Greppi, Sabrina Carpentier, Emilie Narni-Mancinelli, Laura Chiossone and Eric Vivier
    Cancer Discov January 1 2021 11 (1) 34-44; DOI:10.1158/2159-8290.CD-20-0655

  • Reviews
    Outlook for New CAR-Based Therapies with a Focus on CAR NK Cells: What Lies Beyond CAR-Engineered T Cells in the Race against Cancer
    May Daher and Katayoun Rezvani
    Cancer Discov January 1 2021 11 (1) 45-58; DOI:10.1158/2159-8290.CD-20-0556

  • Reviews
    Tumor Mutational Burden as a Predictive Biomarker in Solid Tumors
    Dan Sha, Zhaohui Jin, Jan Budczies, Klaus Kluck, Albrecht Stenzinger and Frank A. Sinicrope
    Cancer Discov December 1 2020 10 (12) 1808-1825; DOI:10.1158/2159-8290.CD-20-0522

  • Reviews
    Targeting Metabolic Plasticity and Flexibility Dynamics for Cancer Therapy
    Sarah-Maria Fendt, Christian Frezza and Ayelet Erez
    Cancer Discov December 1 2020 10 (12) 1797-1807; DOI:10.1158/2159-8290.CD-20-0844

News from Cancer Discovery

  • Proteomics Sharpens Brain Tumor Genomic Analysis
    Combination approach uncovers novel treatment avenues.
  • More Data, More Benefit with T-DXd in Breast Cancer
    With longer follow-up, PFS increases; early OS results seem promising.
  • Piecing the Puzzle of Exceptional Responders
    NCI initiative yields mechanistic explanations for nearly one quarter of standout responses.

More Cancer Discovery news   »

Noted This Week, January 8–14   »

OnlineFirst Research Articles & Briefs

  • Correction of FPR1 Defect
    Julie Le Naour, et al.
  • Somatic Mutations and Cancer Risk in Skin across the Body
    Joanna C. Fowler, et al.
  • Modeling ARID1A-deficient tumorigenesis in human organoids
    Yuan-Hung Lo, et al.
  • CRISPR Screening of CAR T Cells and Cancer Stem Cells
    Dongrui Wang, et al.
  • Serine biosynthesis is a vulnerability in FLT3-ITD AML
    Stefan Bjelosevic, et al.
Show more
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OnlineFirst Research Watch

  • Epstein–Barr Virus–Induced Antitumor Immune Response May Be Harnessable
  • FBXO44 Silences Repetitive Elements during DNA Replication in Cancer
  • A CD40 Agonistic Antibody Shows Signs of Efficacy in Pancreatic Cancer
  • Cryo-EM Structures Reveal Mechanism of Anticancer MCT1 Inhibitors
  • First Trial of a DARPin for Cancer Shows Promising Efficacy Signal
Show more

Trending - Altmetric

  • Article has an altmetric score of 604
    Priority COVID-19 Vaccination for Patients with Cancer while Vaccine Supply Is Limited
    Last mentioned on Sun Jan 17 2021
  • Article has an altmetric score of 344
    A pro-carcinogenic colon microbe promotes breast tumorigenesis and metastatic progression and concomitantly activates Notch and βcatenin axes
    Last mentioned on Mon Jan 18 2021
  • Article has an altmetric score of 262
    Metastasis and immune evasion from extracellular cGAMP hydrolysis
    Last mentioned on Thu Jan 14 2021
  • Article has an altmetric score of 101
    Durable Suppression of Acquired MEK Inhibitor Resistance in Cancer by Sequestering MEK from ERK and Promoting Anti-Tumor T-cell Immunity
    Last mentioned on Mon Dec 21 2020
  • Article has an altmetric score of 100
    Phenotypic mapping of pathological crosstalk between glioblastoma and innate immune cells by synthetic genetic tracing
    Last mentioned on Wed Jan 13 2021
  • See more
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Cancer Discovery
eISSN: 2159-8290
ISSN: 2159-8274

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