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Read, Science in Society: Priority COVID-19 vaccination for patients with cancer while vaccine supply is limited
- Research Articles | AuthorChoiceTimothy A. Yap, David S.P. Tan, Angelika Terbuch, Reece Caldwell, Christina Guo, Boon Cher Goh, Valerie Heong, Noor R. Md. Haris, Saira Bashir, Yvette Drew, David S. Hong, Funda Meric-Bernstam, Gary Wilkinson, Joseph Hreiki, Antje M. Wengner, Friedhelm Bladt, Andreas Schlicker, Matthias Ludwig, Yinghui Zhou, Li Liu, Sonal Bordia, Ruth Plummer, Eleni Lagkadinou and Johann S. de BonoCancer Discov January 1 2021 11 (1) 80-91; DOI:10.1158/2159-8290.CD-20-0868
In a phase I trial, the ATR inhibitor BAY 1895344 showed preliminary evidence of efficacy against advanced solid tumors, particularly those with low ATM protein levels and/or ATM mutations.
- Research ArticlesSusanne Grunewald, Lillian R. Klug, Thomas Mühlenberg, Jonas Lategahn, Johanna Falkenhorst, Ajia Town, Christiane Ehrt, Eva Wardelmann, Wolfgang Hartmann, Hans-Ulrich Schildhaus, Juergen Treckmann, Jonathan A. Fletcher, Sascha Jung, Paul Czodrowski, Stephen Miller, Oleg Schmidt-Kittler, Daniel Rauh, Michael C. Heinrich and Sebastian BauerCancer Discov January 1 2021 11 (1) 108-125; DOI:10.1158/2159-8290.CD-20-0487
PDGFRA-mutant gastrointestinal stromal tumors that develop resistance to PDGFRA inhibition harbored secondary mutations in the PDGFRA kinase domain, and these tumors were still dependent on oncogenic PDGFRA signaling.
- Research Articles | AuthorChoiceMarco H. Hofmann, Michael Gmachl, Juergen Ramharter, Fabio Savarese, Daniel Gerlach, Joseph R. Marszalek, Michael P. Sanderson, Dirk Kessler, Francesca Trapani, Heribert Arnhof, Klaus Rumpel, Dana-Adriana Botesteanu, Peter Ettmayer, Thomas Gerstberger, Christiane Kofink, Tobias Wunberg, Andreas Zoephel, Szu-Chin Fu, Jessica L. Teh, Jark Böttcher, Nikolai Pototschnig, Franziska Schachinger, Katharina Schipany, Simone Lieb, Christopher P. Vellano, Jonathan C. O'Connell, Rachel L. Mendes, Jurgen Moll, Mark Petronczki, Timothy P. Heffernan, Mark Pearson, Darryl B. McConnell and Norbert KrautCancer Discov January 1 2021 11 (1) 142-157; DOI:10.1158/2159-8290.CD-20-0142
A novel small-molecule drug, BI-3406, was used to block interactions between KRAS and the guanine exchange factor SOS1, hindering GTP binding by KRAS and thus reducing its activity to prevent tumor cell growth in vitro and in vivo.
- Research Articles | AuthorChoiceMika Kamata-Sakurai, Yoshinori Narita, Yuji Hori, Takayuki Nemoto, Ryo Uchikawa, Masaki Honda, Naoka Hironiwa, Kenji Taniguchi, Meiri Shida-Kawazoe, Shoichi Metsugi, Taro Miyazaki, Naoko A. Wada, Yuki Ohte, Shun Shimizu, Hirofumi Mikami, Tatsuhiko Tachibana, Natsuki Ono, Kenji Adachi, Tetsushi Sakiyama, Tomochika Matsushita, Shojiro Kadono, Shun-ichiro Komatsu, Akihisa Sakamoto, Sayuri Horikawa, Ayano Hirako, Koki Hamada, Sotaro Naoi, Nasa Savory, Yasuko Satoh, Motohiko Sato, Yuki Noguchi, Junko Shinozuka, Haruka Kuroi, Ami Ito, Tetsuya Wakabayashi, Masaki Kamimura, Fumihisa Isomura, Yasushi Tomii, Noriaki Sawada, Atsuhiko Kato, Otoya Ueda, Yoshito Nakanishi, Mika Endo, Kou-ichi Jishage, Yoshiki Kawabe, Takehisa Kitazawa and Tomoyuki IgawaCancer Discov January 1 2021 11 (1) 158-175; DOI:10.1158/2159-8290.CD-20-0328
An extracellular ATP–activated agonistic antibody to CD137, which promotes T-cell survival and proliferation, showed antitumor efficacy in multiple in vivo models, causing T-cell activation within tumors without off-target toxicity.
- ReviewsBeatriz Cózar, Marco Greppi, Sabrina Carpentier, Emilie Narni-Mancinelli, Laura Chiossone and Eric VivierCancer Discov January 1 2021 11 (1) 34-44; DOI:10.1158/2159-8290.CD-20-0655
- ReviewsMay Daher and Katayoun RezvaniCancer Discov January 1 2021 11 (1) 45-58; DOI:10.1158/2159-8290.CD-20-0556
- ReviewsDan Sha, Zhaohui Jin, Jan Budczies, Klaus Kluck, Albrecht Stenzinger and Frank A. SinicropeCancer Discov December 1 2020 10 (12) 1808-1825; DOI:10.1158/2159-8290.CD-20-0522
- ReviewsSarah-Maria Fendt, Christian Frezza and Ayelet ErezCancer Discov December 1 2020 10 (12) 1797-1807; DOI:10.1158/2159-8290.CD-20-0844
News from Cancer Discovery
- Proteomics Sharpens Brain Tumor Genomic Analysis
Combination approach uncovers novel treatment avenues. - More Data, More Benefit with T-DXd in Breast Cancer
With longer follow-up, PFS increases; early OS results seem promising. - Piecing the Puzzle of Exceptional Responders
NCI initiative yields mechanistic explanations for nearly one quarter of standout responses.
OnlineFirst Research Articles & Briefs
- Correction of FPR1 DefectJulie Le Naour, et al.
- Somatic Mutations and Cancer Risk in Skin across the BodyJoanna C. Fowler, et al.
- Modeling ARID1A-deficient tumorigenesis in human organoidsYuan-Hung Lo, et al.
- CRISPR Screening of CAR T Cells and Cancer Stem CellsDongrui Wang, et al.
- Serine biosynthesis is a vulnerability in FLT3-ITD AMLStefan Bjelosevic, et al.
OnlineFirst Research Watch
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- Priority COVID-19 Vaccination for Patients with Cancer while Vaccine Supply Is LimitedLast mentioned on Sun Jan 17 2021
- Metastasis and immune evasion from extracellular cGAMP hydrolysisLast mentioned on Thu Jan 14 2021
- Phenotypic mapping of pathological crosstalk between glioblastoma and innate immune cells by synthetic genetic tracingLast mentioned on Wed Jan 13 2021
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