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Read, Science in Society: Rethinking Cancer Clinical Trial Conduct Induced by COVID-19: An Academic Center, Industry, Government, and Regulatory Agency Perspective.

From the Current Issue

  • Research Articles | Open Access
    Genomes for Kids: The Scope of Pathogenic Mutations in Pediatric Cancer Revealed by Comprehensive DNA and RNA Sequencing
    Scott Newman, Joy Nakitandwe, Chimene A. Kesserwan, Elizabeth M. Azzato, David A. Wheeler, Michael Rusch, Sheila Shurtleff, Dale J. Hedges, Kayla V. Hamilton, Scott G. Foy, Michael N. Edmonson, Andrew Thrasher, Armita Bahrami, Brent A. Orr, Jeffery M. Klco, Jiali Gu, Lynn W. Harrison, Lu Wang, Michael R. Clay, Annastasia Ouma, Antonina Silkov, Yanling Liu, Zhaojie Zhang, Yu Liu, Samuel W. Brady, Xin Zhou, Ti-Cheng Chang, Manjusha Pande, Eric Davis, Jared Becksfort, Aman Patel, Mark R. Wilkinson, Delaram Rahbarinia, Manish Kubal, Jamie L. Maciaszek, Victor Pastor, Jay Knight, Alexander M. Gout, Jian Wang, Zhaohui Gu, Charles G. Mullighan, Rose B. McGee, Emily A. Quinn, Regina Nuccio, Roya Mostafavi, Elsie L. Gerhardt, Leslie M. Taylor, Jessica M. Valdez, Stacy J. Hines-Dowell, Alberto S. Pappo, Giles Robinson, Liza-Marie Johnson, Ching-Hon Pui, David W. Ellison, James R. Downing, Jinghui Zhang and Kim E. Nichols
    Cancer Discov December 1 2021 11 (12) 3008-3027; DOI:10.1158/2159-8290.CD-20-1631

    Analysis of data from the Genomes for Kids research study reveals the value of three-platform whole-genome, wholeexome, and RNA sequencing in identifying clinically and biologically relevant lesions in pediatric cancer.

  • Research Articles
    Longitudinal Single-Cell Dynamics of Chromatin Accessibility and Mitochondrial Mutations in Chronic Lymphocytic Leukemia Mirror Disease History
    Livius Penter, Satyen H. Gohil, Caleb Lareau, Leif S. Ludwig, Erin M. Parry, Teddy Huang, Shuqiang Li, Wandi Zhang, Dimitri Livitz, Ignaty Leshchiner, Laxmi Parida, Gad Getz, Laura Z. Rassenti, Thomas J. Kipps, Jennifer R. Brown, Matthew S. Davids, Donna S. Neuberg, Kenneth J. Livak, Vijay G. Sankaran and Catherine J. Wu
    Cancer Discov December 1 2021 11 (12) 3048-3063; DOI:10.1158/2159-8290.CD-21-0276

    Single-cell analysis of serial chronic lymphocytic leukemia (CLL) samples highlights the potential of mitochondrial DNA mutations as natural barcodes, and, along with chromatin accessibility and CNV changes, reveals insight into the clonal evolution of CLL.

  • Research Articles
    Cholesterol Auxotrophy as a Targetable Vulnerability in Clear Cell Renal Cell Carcinoma
    Romain Riscal, Caroline J. Bull, Clementina Mesaros, Jennifer M. Finan, Madeleine Carens, Elaine S. Ho, Jimmy P. Xu, Jason Godfrey, Paul Brennan, Mattias Johansson, Mark P. Purdue, Stephen J. Chanock, Daniela Mariosa, Nicholas J. Timpson, Emma E. Vincent, Brian Keith, Ian A. Blair, Nicolas Skuli and M. Celeste Simon
    Cancer Discov December 1 2021 11 (12) 3106-3125; DOI:10.1158/2159-8290.CD-21-0211

    Multi-omic analyses of clear cell renal cell carcinoma revealed a strict exogenous cholesterol dependency as a novel therapeutic strategy by limiting cholesterol availability and/or inhibiting a key cholesterol transporter.

  • Research Articles
    A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative Neoplasms
    Hamza Celik, Ethan Krug, Christine R. Zhang, Wentao Han, Nancy Issa, Won Kyun Koh, Hassan Bjeije, Ostap Kukhar, Maggie Allen, Tiandao Li, Daniel A.C. Fisher, Jared S. Fowles, Terrence N. Wong, Matthew C. Stubbs, Holly K. Koblish, Stephen T. Oh and Grant A. Challen
    Cancer Discov December 1 2021 11 (12) 3126-3141; DOI:10.1158/2159-8290.CD-20-1652

    A patient-derived xenograft system was developed that enables engraftment of primary cells from patients with myelofibrosis (MF) and transmission of phenotypes, such as bone marrow fibrosis, and genotypes including MF driver mutations in mice with expression of human myeloid promoting cytokines.

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