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A Decade of Cancer Discovery: read the editorial by Luis A. Diaz and Lewis C. Cantley.

Read the February issue!
About the cover: Fowler, et al., discovered that the mutation density in healthy human skin differed from location to location across the body. Common sites for skin cancer bore more mutations than uncommon sites. Find out more in the article.
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Keep up with findings in the cancer research field via our website, highlighting must-read industry news, and on Twitter @CD_AACR!
Research Article
Read: Poor Survival and Differential Impact of Genetic Features of Black Patients with Acute Myeloid Leukemia, Bhavana Bhatnagar, et al.
Research Briefs
Read: Genetic ancestry contributes to somatic mutations in lung cancers from admixed Latin American populations, Jian Carrot-Zhang, et al.
Research Article
Read: Machine learning and chemico-genomics approach defines and predicts cross-talk of Hippo and MAPK pathways, Trang H Pham, et al.

From the Current Issue

Research Briefs | AuthorChoice

Lower Airway Dysbiosis Affects Lung Cancer Progression

Jun-Chieh J. Tsay, Benjamin G. Wu, Imran Sulaiman, Katherine Gershner, Rosemary Schluger, Yonghua Li, Ting-An Yie, Peter Meyn, Evan Olsen, Luisannay Perez, Brendan Franca, Joseph Carpenito, Tadasu Iizumi, Mariam El-Ashmawy, Michelle Badri, James T. Morton, Nan Shen, Linchen He, Gaetane Michaud, Samaan Rafeq, Jamie L. Bessich, Robert L. Smith, Harald Sauthoff, Kevin Felner, Ray Pillai, Anastasia-Maria Zavitsanou, Sergei B. Koralov, Valeria Mezzano, Cynthia A. Loomis, Andre L. Moreira, William Moore, Aristotelis Tsirigos, Adriana Heguy, William N. Rom, Daniel H. Sterman, Harvey I. Pass, Jose C. Clemente, Huilin Li, Richard Bonneau, Kwok-Kin Wong, Thales Papagiannakopoulos and Leopoldo N. Segal

Cancer Discov February 1 2021 11 (2) 293-307; DOI:10.1158/2159-8290.CD-20-0263

Lower airway dysbiosis characterized by excessive colonization with oral commensal microbes, particularly Veillonella parvula, was a predictor of poor prognosis in lung cancer, and in vivo experiments supported a role for V. parvula colonization in decreasing survival.
Research Articles | AuthorChoice

Personalized Antibodies for Gastroesophageal Adenocarcinoma (PANGEA): A Phase II Study Evaluating an Individualized Treatment Strategy for Metastatic Disease

Daniel V.T. Catenacci, Stephanie Moya, Samantha Lomnicki, Leah M. Chase, Bryan F. Peterson, Natalie Reizine, Lindsay Alpert, Namrata Setia, Shu-Yuan Xiao, John Hart, Uzma D. Siddiqui, D. Kyle Hogarth, Oliver S. Eng, Kiran Turaga, Kevin Roggin, Mitchell C. Posner, Paul Chang, Sunil Narula, Murtuza Rampurwala, Yuan Ji, Theodore Karrison, Chih-Yi Liao, Blase N. Polite and Hedy L. Kindler

Cancer Discov February 1 2021 11 (2) 308-325; DOI:10.1158/2159-8290.CD-20-1408

In a phase II clinical trial, personalized antibodies plus molecularly targeted chemotherapy improved median overall survival and the one-year survival rate in patients with gastroesophageal adenocarcinoma relative to historical survival data.
Research Articles

Timed Ang2-Targeted Therapy Identifies the Angiopoietin–Tie Pathway as Key Regulator of Fatal Lymphogenous Metastasis

Nicolas Gengenbacher, Mahak Singhal, Carolin Mogler, Ling Hai, Laura Milde, Ashik Ahmed Abdul Pari, Eva Besemfelder, Claudine Fricke, Daniel Baumann, Stephanie Gehrs, Jochen Utikal, Moritz Felcht, Junhao Hu, Matthias Schlesner, Rienk Offringa, Sudhakar R. Chintharlapalli and Hellmut G. Augustin

Cancer Discov February 1 2021 11 (2) 424-445; DOI:10.1158/2159-8290.CD-20-0122

A hindrance to the study of metastasis via lymphatic vessels with lymph nodes as intermediate sites was overcome using a genetically engineered mouse model–derived allograft model, the use of which uncovered the Ang2–Tie2 pathway as a critical dependency.
Research Articles

Netrin G1 Promotes Pancreatic Tumorigenesis through Cancer-Associated Fibroblast–Driven Nutritional Support and Immunosuppression

Ralph Francescone, Débora Barbosa Vendramini-Costa, Janusz Franco-Barraza, Jessica Wagner, Alexander Muir, Allison N. Lau, Linara Gabitova, Tatiana Pazina, Sapna Gupta, Tiffany Luong, Dustin Rollins, Ruchi Malik, Roshan J. Thapa, Diana Restifo, Yan Zhou, Kathy Q. Cai, Harvey H. Hensley, Yinfei Tan, Warren D. Kruger, Karthik Devarajan, Siddharth Balachandran, Andres J. Klein-Szanto, Huamin Wang, Wafik S. El-Deiry, Matthew G. Vander Heiden, Suraj Peri, Kerry S. Campbell, Igor Astsaturov and Edna Cukierman

Cancer Discov February 1 2021 11 (2) 446-479; DOI:10.1158/2159-8290.CD-20-0775

The glutamatergic presynaptic protein Netrin-G1 was found to be a major contributor to the metabolic and immunosuppressive tumor microenvironment in pancreatic ductal adenocarcinoma, and blocking Netrin-G1 in vivo suppressed tumorigenesis.

Recent Reviews

Reviews

Modes of Regulated Cell Death in Cancer

Elle Koren and Yaron Fuchs

Cancer Discov February 1 2021 11 (2) 245-265; DOI:10.1158/2159-8290.CD-20-0789
Reviews

Fueling the Fire: Inflammatory Forms of Cell Death and Implications for Cancer Immunotherapy

Sheera R. Rosenbaum, Nicole A. Wilski and Andrew E. Aplin

Cancer Discov February 1 2021 11 (2) 266-281; DOI:10.1158/2159-8290.CD-20-0805
Reviews

Tumor-Infiltrating Natural Killer Cells

Beatriz Cózar, Marco Greppi, Sabrina Carpentier, Emilie Narni-Mancinelli, Laura Chiossone and Eric Vivier

Cancer Discov January 1 2021 11 (1) 34-44; DOI:10.1158/2159-8290.CD-20-0655
Reviews

Outlook for New CAR-Based Therapies with a Focus on CAR NK Cells: What Lies Beyond CAR-Engineered T Cells in the Race against Cancer

May Daher and Katayoun Rezvani

Cancer Discov January 1 2021 11 (1) 45-58; DOI:10.1158/2159-8290.CD-20-0556