Table of Contents

Research Articles

• Research Articles

  Genetic and Functional Studies Implicate HIF1α as a 14q Kidney Cancer Suppressor Gene

  Chuan Shen, Rameen Beroukhim, Steven E. Schumacher, Jing Zhou, Michelle Chang, Sabina Signoretti and William G. Kaelin Jr

  Cancer Discov August 1 2011 1 (3) 222-235; DOI:10.1158/2159-8290.CD-11-0098

  
  

  Genetic and functional studies demonstrate that loss of chromosome 14q is a critical event in the etiology of clear cell renal carcinoma and identify HIF1α as a tumor suppressor gene in this disease.

• Research Articles

  Response and Resistance to NF-κB Inhibitors in Mouse Models of Lung Adenocarcinoma

  Wen Xue, Etienne Meylan, Trudy G. Oliver, David M. Feldser, Monte M. Winslow, Roderick Bronson and Tyler Jacks

  Cancer Discov August 1 2011 1 (3) 236-247; DOI:10.1158/2159-8290.CD-11-0073

  
  

  This study provides preclinical evidence that the NF-κB pathway is a potential therapeutic target in a subset of lung adenocarcinomas that have activation of the NF-κB pathway.

• Research Articles

  mTOR Kinase Inhibition Causes Feedback-Dependent Biphasic Regulation of AKT Signaling

  Vanessa S. Rodrik-Outmezguine, Sarat Chandarlapaty, Nen C. Pagano, Poulikos I. Poulikakos, Maurizio Scaltriti, Elizabeth Moskatel, José Baselga, Sylvie Guichard and Neal Rosen

  Cancer Discov August 1 2011 1 (3) 248-259; DOI:10.1158/2159-8290.CD-11-0085

  
  

  Inhibition of mTOR kinase causes biphasic regulation of AKT signaling involving receptor tyrosine kinases.

• Research Articles | Free Article

  Functional Viability Profiles of Breast Cancer

  Rachel Brough, Jessica R. Frankum, David Sims, Alan Mackay, Ana M. Mendes-Pereira, Ilirjana Bajrami, Sara Costa-Cabral, Rumana Rafiq, Amar S. Ahmad, Maria Antonietta Cerone, Rachael Natrajan, Rachel Sharpe, Kai-Keen Shiu, Daniel Wetterskog, Konstantine J. Dedes, Maryou B. Lambros, Teeara Rawjee, Spiros Linardopoulos, Jorge S. Reis-Filho, Nicholas C. Turner, Christopher J. Lord and Alan Ashworth

  Cancer Discov August 1 2011 1 (3) 260-273; DOI:10.1158/2159-8290.CD-11-0107

  
  

  Functional RNAi screen exploiting synthetic lethality identifies genes critical for growth and survival of breast cancer cells as well as potential therapeutic targets.