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Cancer Discovery
Cancer Discovery
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Table of Contents

In This Issue

  • In This Issue
    In This Issue
    Cancer Discov August 1 2011 1 (3) 189-189; DOI:10.1158/2159-8290.CD-ITI11-03

News in Brief

  • News in Brief
    People
    Cancer Discov August 1 2011 1 (3) 190-190; DOI:10.1158/2159-8290.CD-NB080111-07

  • News in Brief
    Breaking BRCA Heightens PARP Inhibitor Action
    Cancer Discov August 1 2011 1 (3) 190-190; DOI:10.1158/2159-8290.CD-NB080111-08

  • News in Brief
    Molecular Anchor Restricts Protein Movement
    Cancer Discov August 1 2011 1 (3) 190-191; DOI:10.1158/2159-8290.CD-NB080111-09

  • News in Brief
    Cancers Show Chaos in DNA Methylation
    Cancer Discov August 1 2011 1 (3) 191-191; DOI:10.1158/2159-8290.CD-NB080111-10

  • News in Brief
    Battles in the War on Cancer: Gleevec Hits Its Targets
    Cancer Discov August 1 2011 1 (3) 191-191; DOI:10.1158/2159-8290.CD-NB080111-11

  • News in Brief
    Circulating Tumor Cells Present EMT Marks in Human Cancers
    Cancer Discov August 1 2011 1 (3) 192-192; DOI:10.1158/2159-8290.CD-NB080111-12

  • News in Brief
    Astronomy Research Suggests Tumor Tools
    Cancer Discov August 1 2011 1 (3) 192-192; DOI:10.1158/2159-8290.CD-NB080111-13

  • News in Brief
    Noted
    Cancer Discov August 1 2011 1 (3) 192-192; DOI:10.1158/2159-8290.CD-NB080111-14

News in Depth

  • News in Depth
    Q&A: Anna Barker on The Cancer Genome Atlas
    Cancer Discov August 1 2011 1 (3) 193-193; DOI:10.1158/2159-8290.CD-ND11-03

  • News in Depth
    Revamping the Clinical Trials System
    Cancer Discov August 1 2011 1 (3) 194-194; DOI:10.1158/2159-8290.CD-ND11-04

Research Watch

  • Tumor Microenvironment

    • Research Watch
      Hypoxic Conditions Lead to Recruitment of Treg Cells
      Cancer Discov August 1 2011 1 (3) 195-195; DOI:10.1158/2159-8290.CD-RW042711-09

  • Tumorigenesis

    • Research Watch
      SHP2 Converts Parafibromin/Cdc73 from Tumor Suppressor to Oncoprotein
      Cancer Discov August 1 2011 1 (3) 195-195; DOI:10.1158/2159-8290.CD-RW042711-10

  • Glioma

    • Research Watch
      MADM Identifies OPC as Glioma Cell of Origin
      Cancer Discov August 1 2011 1 (3) 196-196; DOI:10.1158/2159-8290.CD-RW042711-11

  • Leukemia

    • Research Watch
      DOT1L Is a Therapeutic Target in Mixed-lineage Leukemia
      Cancer Discov August 1 2011 1 (3) 196-197; DOI:10.1158/2159-8290.CD-RW042711-12

  • Radiotherapy

    • Research Watch
      Combined Radiotherapy and Androgen-deprivation Therapy
      Cancer Discov August 1 2011 1 (3) 197-197; DOI:10.1158/2159-8290.CD-RW042711-13

  • Genomics

    • Research Watch
      Integrated Genomic Analysis of Ovarian Carcinoma
      Cancer Discov August 1 2011 1 (3) 197-197; DOI:10.1158/2159-8290.CD-RW042711-14

In the Spotlight

  • In the Spotlight
    Unraveling the Role of Hypoxia-Inducible Factor in Renal Cell Carcinoma: A Biological and Therapeutic Perspective
    Sumanta Kumar Pal and Robert A. Figlin
    Cancer Discov August 1 2011 1 (3) 198-199; DOI:10.1158/2159-8290.CD-11-0149

  • In the Spotlight
    Targeting NF-κB in Mouse Models of Lung Adenocarcinoma
    Carter Van Waes
    Cancer Discov August 1 2011 1 (3) 200-202; DOI:10.1158/2159-8290.CD-11-0159

  • In the Spotlight
    mTOR Inhibition, the Second Generation: ATP-Competitive mTOR Inhibitor Initiates Unexpected Receptor Tyrosine Kinase–Driven Feedback Loop
    Megan Keniry and Ramon Parsons
    Cancer Discov August 1 2011 1 (3) 203-204; DOI:10.1158/2159-8290.CD-11-0157

  • In the Spotlight
    Functional Subtyping of Breast Cancer
    Roderick L. Beijersbergen and René Bernards
    Cancer Discov August 1 2011 1 (3) 205-206; DOI:10.1158/2159-8290.CD-11-0163

Prospective

  • Prospective
    Parallel Anticancer Drug Development and Molecular Stratification to Qualify Predictive Biomarkers: Dealing with Obstacles Hindering Progress
    Victor Moreno Garcia, Philippe A. Cassier and Johann de Bono
    Cancer Discov August 1 2011 1 (3) 207-212; DOI:10.1158/2159-8290.CD-11-0161

Mini Review

  • Mini Review
    A Shining Light in the Darkness for the Treatment of Pancreatic Neuroendocrine Tumors
    Jaume Capdevila and Josep Tabernero
    Cancer Discov August 1 2011 1 (3) 213-221; DOI:10.1158/2159-8290.CD-11-0151

Research Articles

  • Research Articles
    Genetic and Functional Studies Implicate HIF1α as a 14q Kidney Cancer Suppressor Gene
    Chuan Shen, Rameen Beroukhim, Steven E. Schumacher, Jing Zhou, Michelle Chang, Sabina Signoretti and William G. Kaelin Jr
    Cancer Discov August 1 2011 1 (3) 222-235; DOI:10.1158/2159-8290.CD-11-0098

    Genetic and functional studies demonstrate that loss of chromosome 14q is a critical event in the etiology of clear cell renal carcinoma and identify HIF1α as a tumor suppressor gene in this disease.

  • Research Articles
    Response and Resistance to NF-κB Inhibitors in Mouse Models of Lung Adenocarcinoma
    Wen Xue, Etienne Meylan, Trudy G. Oliver, David M. Feldser, Monte M. Winslow, Roderick Bronson and Tyler Jacks
    Cancer Discov August 1 2011 1 (3) 236-247; DOI:10.1158/2159-8290.CD-11-0073

    This study provides preclinical evidence that the NF-κB pathway is a potential therapeutic target in a subset of lung adenocarcinomas that have activation of the NF-κB pathway.

  • Research Articles
    mTOR Kinase Inhibition Causes Feedback-Dependent Biphasic Regulation of AKT Signaling
    Vanessa S. Rodrik-Outmezguine, Sarat Chandarlapaty, Nen C. Pagano, Poulikos I. Poulikakos, Maurizio Scaltriti, Elizabeth Moskatel, José Baselga, Sylvie Guichard and Neal Rosen
    Cancer Discov August 1 2011 1 (3) 248-259; DOI:10.1158/2159-8290.CD-11-0085

    Inhibition of mTOR kinase causes biphasic regulation of AKT signaling involving receptor tyrosine kinases.

  • Research Articles | Free Article
    Functional Viability Profiles of Breast Cancer
    Rachel Brough, Jessica R. Frankum, David Sims, Alan Mackay, Ana M. Mendes-Pereira, Ilirjana Bajrami, Sara Costa-Cabral, Rumana Rafiq, Amar S. Ahmad, Maria Antonietta Cerone, Rachael Natrajan, Rachel Sharpe, Kai-Keen Shiu, Daniel Wetterskog, Konstantine J. Dedes, Maryou B. Lambros, Teeara Rawjee, Spiros Linardopoulos, Jorge S. Reis-Filho, Nicholas C. Turner, Christopher J. Lord and Alan Ashworth
    Cancer Discov August 1 2011 1 (3) 260-273; DOI:10.1158/2159-8290.CD-11-0107

    Functional RNAi screen exploiting synthetic lethality identifies genes critical for growth and survival of breast cancer cells as well as potential therapeutic targets.

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Cancer Discovery: 1 (3)
August 2011
Volume 1, Issue 3
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  • The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data
  • Macrophages Regulate Response to Chemotherapy
  • Core Resistance Mechanisms and Genetic Evolution of Melanoma under BRAF Inhibitor Selection
  • EGFR Mediates RAF Inhibitor Resistance in BRAF-Mutant Colorectal Cancer
  • Novel Mutant-Selective EGFR Inhibitor Overcomes Drug Resistance
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