In This Issue
Cancer Discov August 1 2011 1 (3) 189-189; DOI:10.1158/2159-8290.CD-ITI11-03
Genetic and functional studies demonstrate that loss of chromosome 14q is a critical event in the etiology of clear cell renal carcinoma and identify HIF1α as a tumor suppressor gene in this disease.
This study provides preclinical evidence that the NF-κB pathway is a potential therapeutic target in a subset of lung adenocarcinomas that have activation of the NF-κB pathway.
Inhibition of mTOR kinase causes biphasic regulation of AKT signaling involving receptor tyrosine kinases.
Functional RNAi screen exploiting synthetic lethality identifies genes critical for growth and survival of breast cancer cells as well as potential therapeutic targets.