Cancer Discovery: 1 (7)

In This Issue

In This Issue

In This Issue

Cancer Discov December 1 2011 1 (7) 539-540; DOI:10.1158/2159-8290.CD-ITI11-07

In the Spotlight

In the Spotlight

Anti-MET Targeted Therapy Has Come of Age: The First Durable Complete Response with MetMAb in Metastatic Gastric Cancer

Yan Feng and Patrick C. Ma

Cancer Discov December 1 2011 1 (7) 550-554; DOI:10.1158/2159-8290.CD-11-0289
In the Spotlight

Genomic Investigation of Dedifferentiated Liposarcoma Suggests a Role for Therapeutic Targeting of the Tumor Epigenome

Paul S. Meltzer and Lee J. Helman

Cancer Discov December 1 2011 1 (7) 555-556; DOI:10.1158/2159-8290.CD-11-0291
In the Spotlight

A Combined Epigenetic Therapy Equals the Efficacy of Conventional Chemotherapy in Refractory Advanced Non–Small Cell Lung Cancer

Manuel Rodríguez-Paredes and Manel Esteller

Cancer Discov December 1 2011 1 (7) 557-559; DOI:10.1158/2159-8290.CD-11-0271
In the Spotlight

CRKL as a Lung Cancer Oncogene and Mediator of Acquired Resistance to EGFR Inhibitors: Is It All That It Is Cracked Up to Be?

Marc Ladanyi

Cancer Discov December 1 2011 1 (7) 560-561; DOI:10.1158/2159-8290.CD-11-0295

Review

Review

PI3Kδ Inhibitors in Cancer: Rationale and Serendipity Merge in the Clinic

David A. Fruman and Christian Rommel

Cancer Discov December 1 2011 1 (7) 562-572; DOI:10.1158/2159-8290.CD-11-0249

Research Briefs

Research Briefs

Durable Complete Response of Metastatic Gastric Cancer with Anti-Met Therapy Followed by Resistance at Recurrence

Daniel V. T. Catenacci, Les Henderson, Shu-Yuan Xiao, Premal Patel, Robert L. Yauch, Priti Hegde, Jiping Zha, Ajay Pandita, Amy Peterson and Ravi Salgia

Cancer Discov December 1 2011 1 (7) 573-579; DOI:10.1158/2159-8290.CD-11-0175

An anti-MET monoclonal antibody elicited a 2-year complete response in a patient with metastatic gastric cancer with MET gene polysomy and autocrine HGF production.
Research Briefs

A Novel Platform for Detection of CK⁺ and CK⁻ CTCs

Chad V. Pecot, Farideh Z. Bischoff, Julie Ann Mayer, Karina L. Wong, Tam Pham, Justin Bottsford-Miller, Rebecca L. Stone, Yvonne G. Lin, Padmavathi Jaladurgam, Ju Won Roh, Blake W. Goodman, William M. Merritt, Tony J. Pircher, Stephen D. Mikolajczyk, Alpa M. Nick, Joseph Celestino, Cathy Eng, Lee M. Ellis, Michael T. Deavers and Anil K. Sood

Cancer Discov December 1 2011 1 (7) 580-586; DOI:10.1158/2159-8290.CD-11-0215

An expanded antibody cocktail combined with a microfluidics platform directly incorporating FISH identifies nonepithelial CTCs.
Research Briefs

Frequent Alterations and Epigenetic Silencing of Differentiation Pathway Genes in Structurally Rearranged Liposarcomas

Barry S. Taylor, Penelope L. DeCarolis, Christina V. Angeles, Fabienne Brenet, Nikolaus Schultz, Cristina R. Antonescu, Joseph M. Scandura, Chris Sander, Agnes J. Viale, Nicholas D. Socci and Samuel Singer

Cancer Discov December 1 2011 1 (7) 587-597; DOI:10.1158/2159-8290.CD-11-0181

Dedifferentiated liposarcomas harbor recurring HDAC1 mutations and exhibit aberrant methylomes, suggesting that epigenetic therapies may be effective in these tumors.

Research Articles

Research Articles | Free Article

Combination Epigenetic Therapy Has Efficacy in Patients with Refractory Advanced Non–Small Cell Lung Cancer

Rosalyn A. Juergens, John Wrangle, Frank P. Vendetti, Sara C. Murphy, Ming Zhao, Barbara Coleman, Rosa Sebree, Kristen Rodgers, Craig M. Hooker, Noreli Franco, Beverly Lee, Salina Tsai, Igor Espinoza Delgado, Michelle A. Rudek, Steven A. Belinsky, James G. Herman, Stephen B. Baylin, Malcolm V. Brock and Charles M. Rudin

Cancer Discov December 1 2011 1 (7) 598-607; DOI:10.1158/2159-8290.CD-11-0214

Objective, long-lasting responses are observed in patients with NSCLC treated with azacitidine and entinostat.
Research Articles

Amplification of CRKL Induces Transformation and Epidermal Growth Factor Receptor Inhibitor Resistance in Human Non–Small Cell Lung Cancers

Hiu Wing Cheung, Jinyan Du, Jesse S. Boehm, Frank He, Barbara A. Weir, Xiaoxing Wang, Mohit Butaney, Lecia V. Sequist, Biao Luo, Jeffrey A. Engelman, David E. Root, Matthew Meyerson, Todd R. Golub, Pasi A. Jänne and William C. Hahn

Cancer Discov December 1 2011 1 (7) 608-625; DOI:10.1158/2159-8290.CD-11-0046

Overexpression of the CRKL adaptor protein activates oncogenic signaling pathways and promotes drug resistance in NSCLC.

News in Brief

News in Brief

People

Cancer Discov December 1 2011 1 (7) 541-541; DOI:10.1158/2159-8290.CD-NB120111-28
News in Brief

Framework Proposed for Immunotherapy Studies

Cancer Discov December 1 2011 1 (7) 541-541; DOI:10.1158/2159-8290.CD-NB111011OL-06
News in Brief

Center-Wide Effort Puts Tumor Scans into Profile

Cancer Discov December 1 2011 1 (7) 541-542; DOI:10.1158/2159-8290.CD-NB111011OL-07
News in Brief

CDC Committee Backs HPV Vaccine for Boys

Cancer Discov December 1 2011 1 (7) 542-542; DOI:10.1158/2159-8290.CD-NB-120111-32
News in Brief

Noted

Cancer Discov December 1 2011 1 (7) 542-542; DOI:10.1158/2159-8290.CD-NB-120111-33
News in Depth

FDA Pulls Approval for Avastin in Breast Cancer

Cancer Discov December 1 2011 1 (7) OF1-OF2; DOI:10.1158/2159-8290.CD-ND112311OL-08
News in Depth

HDAC Inhibitors Show Benefits in Breast Cancer

Cancer Discov December 1 2011 1 (7) OF1-OF2; DOI:10.1158/2159-8290.CD-ND112311OL-07
News in Brief

Phenotypic Profiling Identifies Novel Anticancer Drugs

Cancer Discov December 1 2011 1 (7) OF1-OF1; DOI:10.1158/2159-8290.CD-NB112311OL-11
News in Brief

Automated Pathology Gives Accurate Predictions

Cancer Discov December 1 2011 1 (7) OF1-OF1; DOI:10.1158/2159-8290.CD-NB111711OL-10
News in Brief

Triple-Acting Drug Boosts Prostate Cancer Survival

Cancer Discov December 1 2011 1 (7) OF1-OF1; DOI:10.1158/2159-8290.CD-NB111711OL-09
News in Brief

Analyzing Intact Proteins with Mass Spectrometry

Cancer Discov December 1 2011 1 (7) OF1-OF1; DOI:10.1158/2159-8290.CD-NB111011OL-08

News in Depth

News in Depth

Q&A: William Sellers on Success in Small Molecules

Cancer Discov December 1 2011 1 (7) 543-543; DOI:10.1158/2159-8290.CD-ND120811OL-10
News in Depth

Upcoming Battles in the War on Cancer

Cancer Discov December 1 2011 1 (7) 544-546; DOI:10.1158/2159-8290.CD-ND12-13

Research Watch

Chemotherapy
- Research Watch
  
  Leukemic Cells Are Sensitive to Inhibition of Mitochondrial Translation
  
  Cancer Discov December 1 2011 1 (7) OF1-OF1; DOI:10.1158/2159-8290.CD-RW112311OL-22
Drug Resistance
- Research Watch
  
  ALK Mutants Show Differential Response to Crizotinib
  
  Cancer Discov December 1 2011 1 (7) OF1-OF1; DOI:10.1158/2159-8290.CD-RW112311OL-23
Hepatocellular Carcinoma
- Research Watch
  
  Senescence Surveillance Clears Premalignant Hepatocytes
  
  Cancer Discov December 1 2011 1 (7) OF1-OF1; DOI:10.1158/2159-8290.CD-RW111711OL-19
Immunotherapy
- Research Watch
  
  Inducible Apoptosis Eliminates Patient-Transferred T Cells
  
  Cancer Discov December 1 2011 1 (7) 549-549; DOI:10.1158/2159-8290.CD-RW111711OL-20
- Research Watch
  
  Catumaxomab Activates Immune Response in Malignant Ascites
  
  Cancer Discov December 1 2011 1 (7) 547-547; DOI:10.1158/2159-8290.CD-RW111011OL-17
Metastasis
- Research Watch
  
  Adipocytes Fuel Tumor Growth at Metastatic Sites
  
  Cancer Discov December 1 2011 1 (7) 548-548; DOI:10.1158/2159-8290.CD-RW111011OL-15
Oncogenes
- Research Watch
  
  CRAF Has MEK-Independent Functions in Mitosis and Tumor Progression
  
  Cancer Discov December 1 2011 1 (7) OF1-OF1; DOI:10.1158/2159-8290.CD-RW112311OL-21
Tumor Suppressors
- Research Watch
  
  BRCA1 Tumor Suppression Requires the BRCT Domain
  
  Cancer Discov December 1 2011 1 (7) OF1-OF1; DOI:10.1158/2159-8290.CD-RW111011OL-16
Tumorigenesis
- Research Watch
  
  RAS Mutations Common in Secondary Malignancies Caused by RAF Inhibitors
  
  Cancer Discov December 1 2011 1 (7) 549-549; DOI:10.1158/2159-8290.CD-RW111711OL-18

Corrections

Correction

Correction: Ovarian Cancer Spheroids Use Myosin-Generated Force to Clear the Mesothelium

Cancer Discov December 1 2011 1 (7) 626-626; DOI:10.1158/2159-8290.CD-11-0279
Correction

Correction: Forty Years of Translational Cancer Research

Cancer Discov December 1 2011 1 (7) 627-627; DOI:10.1158/2159-8290.CD-11-0296
Correction

Correction: Drugs, Diagnostic Tests Approved Quickly

Cancer Discov December 1 2011 1 (7) 627-627; DOI:10.1158/2159-8290.CD-11-0299

Acknowledgment to Reviewers

Acknowledgment to Reviewers

Acknowledgment to Reviewers

Cancer Discov December 1 2011 1 (7) 628-628; DOI:10.1158/2159-8290.CD-ACK121411

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Table of Contents

In This Issue

In the Spotlight

Review

Research Briefs

Research Articles

News in Brief

News in Depth

Research Watch

Chemotherapy

Drug Resistance

Hepatocellular Carcinoma

Immunotherapy

Metastasis

Oncogenes

Tumor Suppressors

Tumorigenesis

Corrections

Acknowledgment to Reviewers

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