Skip to main content
  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

AACR logo

  • Register
  • Log in
  • My Cart
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Journal Sections
    • Subscriptions
    • Reviewing
    • Permissions and Reprints
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Collections
      • COVID-19 & Cancer Resource Center
      • Clinical Trials
      • Immuno-oncology
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citation
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
    • Journal Press Releases
  • COVID-19
  • Webinars
  • 10th Anniversary
  • Search More

    Advanced Search

  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in
  • My Cart

Search

  • Advanced search
Cancer Discovery
Cancer Discovery
  • Home
  • About
    • The Journal
    • AACR Journals
    • Journal Sections
    • Subscriptions
    • Reviewing
    • Permissions and Reprints
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Collections
      • COVID-19 & Cancer Resource Center
      • Clinical Trials
      • Immuno-oncology
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citation
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
    • Journal Press Releases
  • COVID-19
  • Webinars
  • 10th Anniversary
  • Search More

    Advanced Search

Table of Contents

In This Issue

  • In This Issue
    In This Issue
    Cancer Discov December 1 2011 1 (7) 539-540; DOI:10.1158/2159-8290.CD-ITI11-07

In the Spotlight

  • In the Spotlight
    Anti-MET Targeted Therapy Has Come of Age: The First Durable Complete Response with MetMAb in Metastatic Gastric Cancer
    Yan Feng and Patrick C. Ma
    Cancer Discov December 1 2011 1 (7) 550-554; DOI:10.1158/2159-8290.CD-11-0289

  • In the Spotlight
    Genomic Investigation of Dedifferentiated Liposarcoma Suggests a Role for Therapeutic Targeting of the Tumor Epigenome
    Paul S. Meltzer and Lee J. Helman
    Cancer Discov December 1 2011 1 (7) 555-556; DOI:10.1158/2159-8290.CD-11-0291

  • In the Spotlight
    A Combined Epigenetic Therapy Equals the Efficacy of Conventional Chemotherapy in Refractory Advanced Non–Small Cell Lung Cancer
    Manuel Rodríguez-Paredes and Manel Esteller
    Cancer Discov December 1 2011 1 (7) 557-559; DOI:10.1158/2159-8290.CD-11-0271

  • In the Spotlight
    CRKL as a Lung Cancer Oncogene and Mediator of Acquired Resistance to EGFR Inhibitors: Is It All That It Is Cracked Up to Be?
    Marc Ladanyi
    Cancer Discov December 1 2011 1 (7) 560-561; DOI:10.1158/2159-8290.CD-11-0295

Review

  • Review
    PI3Kδ Inhibitors in Cancer: Rationale and Serendipity Merge in the Clinic
    David A. Fruman and Christian Rommel
    Cancer Discov December 1 2011 1 (7) 562-572; DOI:10.1158/2159-8290.CD-11-0249

Research Briefs

  • Research Briefs
    Durable Complete Response of Metastatic Gastric Cancer with Anti-Met Therapy Followed by Resistance at Recurrence
    Daniel V. T. Catenacci, Les Henderson, Shu-Yuan Xiao, Premal Patel, Robert L. Yauch, Priti Hegde, Jiping Zha, Ajay Pandita, Amy Peterson and Ravi Salgia
    Cancer Discov December 1 2011 1 (7) 573-579; DOI:10.1158/2159-8290.CD-11-0175

    An anti-MET monoclonal antibody elicited a 2-year complete response in a patient with metastatic gastric cancer with MET gene polysomy and autocrine HGF production.

  • Research Briefs
    A Novel Platform for Detection of CK+ and CK− CTCs
    Chad V. Pecot, Farideh Z. Bischoff, Julie Ann Mayer, Karina L. Wong, Tam Pham, Justin Bottsford-Miller, Rebecca L. Stone, Yvonne G. Lin, Padmavathi Jaladurgam, Ju Won Roh, Blake W. Goodman, William M. Merritt, Tony J. Pircher, Stephen D. Mikolajczyk, Alpa M. Nick, Joseph Celestino, Cathy Eng, Lee M. Ellis, Michael T. Deavers and Anil K. Sood
    Cancer Discov December 1 2011 1 (7) 580-586; DOI:10.1158/2159-8290.CD-11-0215

    An expanded antibody cocktail combined with a microfluidics platform directly incorporating FISH identifies nonepithelial CTCs.

  • Research Briefs
    Frequent Alterations and Epigenetic Silencing of Differentiation Pathway Genes in Structurally Rearranged Liposarcomas
    Barry S. Taylor, Penelope L. DeCarolis, Christina V. Angeles, Fabienne Brenet, Nikolaus Schultz, Cristina R. Antonescu, Joseph M. Scandura, Chris Sander, Agnes J. Viale, Nicholas D. Socci and Samuel Singer
    Cancer Discov December 1 2011 1 (7) 587-597; DOI:10.1158/2159-8290.CD-11-0181

    Dedifferentiated liposarcomas harbor recurring HDAC1 mutations and exhibit aberrant methylomes, suggesting that epigenetic therapies may be effective in these tumors.

Research Articles

  • Research Articles | Free Article
    Combination Epigenetic Therapy Has Efficacy in Patients with Refractory Advanced Non–Small Cell Lung Cancer
    Rosalyn A. Juergens, John Wrangle, Frank P. Vendetti, Sara C. Murphy, Ming Zhao, Barbara Coleman, Rosa Sebree, Kristen Rodgers, Craig M. Hooker, Noreli Franco, Beverly Lee, Salina Tsai, Igor Espinoza Delgado, Michelle A. Rudek, Steven A. Belinsky, James G. Herman, Stephen B. Baylin, Malcolm V. Brock and Charles M. Rudin
    Cancer Discov December 1 2011 1 (7) 598-607; DOI:10.1158/2159-8290.CD-11-0214

    Objective, long-lasting responses are observed in patients with NSCLC treated with azacitidine and entinostat.

  • Research Articles
    Amplification of CRKL Induces Transformation and Epidermal Growth Factor Receptor Inhibitor Resistance in Human Non–Small Cell Lung Cancers
    Hiu Wing Cheung, Jinyan Du, Jesse S. Boehm, Frank He, Barbara A. Weir, Xiaoxing Wang, Mohit Butaney, Lecia V. Sequist, Biao Luo, Jeffrey A. Engelman, David E. Root, Matthew Meyerson, Todd R. Golub, Pasi A. Jänne and William C. Hahn
    Cancer Discov December 1 2011 1 (7) 608-625; DOI:10.1158/2159-8290.CD-11-0046

    Overexpression of the CRKL adaptor protein activates oncogenic signaling pathways and promotes drug resistance in NSCLC.

News in Brief

  • News in Brief
    People
    Cancer Discov December 1 2011 1 (7) 541-541; DOI:10.1158/2159-8290.CD-NB120111-28

  • News in Brief
    Framework Proposed for Immunotherapy Studies
    Cancer Discov December 1 2011 1 (7) 541-541; DOI:10.1158/2159-8290.CD-NB111011OL-06

  • News in Brief
    Center-Wide Effort Puts Tumor Scans into Profile
    Cancer Discov December 1 2011 1 (7) 541-542; DOI:10.1158/2159-8290.CD-NB111011OL-07

  • News in Brief
    CDC Committee Backs HPV Vaccine for Boys
    Cancer Discov December 1 2011 1 (7) 542-542; DOI:10.1158/2159-8290.CD-NB-120111-32

  • News in Brief
    Noted
    Cancer Discov December 1 2011 1 (7) 542-542; DOI:10.1158/2159-8290.CD-NB-120111-33

  • News in Depth
    FDA Pulls Approval for Avastin in Breast Cancer
    Cancer Discov December 1 2011 1 (7) OF1-OF2; DOI:10.1158/2159-8290.CD-ND112311OL-08

  • News in Depth
    HDAC Inhibitors Show Benefits in Breast Cancer
    Cancer Discov December 1 2011 1 (7) OF1-OF2; DOI:10.1158/2159-8290.CD-ND112311OL-07

  • News in Brief
    Phenotypic Profiling Identifies Novel Anticancer Drugs
    Cancer Discov December 1 2011 1 (7) OF1-OF1; DOI:10.1158/2159-8290.CD-NB112311OL-11

  • News in Brief
    Automated Pathology Gives Accurate Predictions
    Cancer Discov December 1 2011 1 (7) OF1-OF1; DOI:10.1158/2159-8290.CD-NB111711OL-10

  • News in Brief
    Triple-Acting Drug Boosts Prostate Cancer Survival
    Cancer Discov December 1 2011 1 (7) OF1-OF1; DOI:10.1158/2159-8290.CD-NB111711OL-09

  • News in Brief
    Analyzing Intact Proteins with Mass Spectrometry
    Cancer Discov December 1 2011 1 (7) OF1-OF1; DOI:10.1158/2159-8290.CD-NB111011OL-08

News in Depth

  • News in Depth
    Q&A: William Sellers on Success in Small Molecules
    Cancer Discov December 1 2011 1 (7) 543-543; DOI:10.1158/2159-8290.CD-ND120811OL-10

  • News in Depth
    Upcoming Battles in the War on Cancer
    Cancer Discov December 1 2011 1 (7) 544-546; DOI:10.1158/2159-8290.CD-ND12-13

Research Watch

  • Chemotherapy

    • Research Watch
      Leukemic Cells Are Sensitive to Inhibition of Mitochondrial Translation
      Cancer Discov December 1 2011 1 (7) OF1-OF1; DOI:10.1158/2159-8290.CD-RW112311OL-22

  • Drug Resistance

    • Research Watch
      ALK Mutants Show Differential Response to Crizotinib
      Cancer Discov December 1 2011 1 (7) OF1-OF1; DOI:10.1158/2159-8290.CD-RW112311OL-23

  • Hepatocellular Carcinoma

    • Research Watch
      Senescence Surveillance Clears Premalignant Hepatocytes
      Cancer Discov December 1 2011 1 (7) OF1-OF1; DOI:10.1158/2159-8290.CD-RW111711OL-19

  • Immunotherapy

    • Research Watch
      Inducible Apoptosis Eliminates Patient-Transferred T Cells
      Cancer Discov December 1 2011 1 (7) 549-549; DOI:10.1158/2159-8290.CD-RW111711OL-20

    • Research Watch
      Catumaxomab Activates Immune Response in Malignant Ascites
      Cancer Discov December 1 2011 1 (7) 547-547; DOI:10.1158/2159-8290.CD-RW111011OL-17

  • Metastasis

    • Research Watch
      Adipocytes Fuel Tumor Growth at Metastatic Sites
      Cancer Discov December 1 2011 1 (7) 548-548; DOI:10.1158/2159-8290.CD-RW111011OL-15

  • Oncogenes

    • Research Watch
      CRAF Has MEK-Independent Functions in Mitosis and Tumor Progression
      Cancer Discov December 1 2011 1 (7) OF1-OF1; DOI:10.1158/2159-8290.CD-RW112311OL-21

  • Tumor Suppressors

    • Research Watch
      BRCA1 Tumor Suppression Requires the BRCT Domain
      Cancer Discov December 1 2011 1 (7) OF1-OF1; DOI:10.1158/2159-8290.CD-RW111011OL-16

  • Tumorigenesis

    • Research Watch
      RAS Mutations Common in Secondary Malignancies Caused by RAF Inhibitors
      Cancer Discov December 1 2011 1 (7) 549-549; DOI:10.1158/2159-8290.CD-RW111711OL-18

Corrections

  • Correction
    Correction: Ovarian Cancer Spheroids Use Myosin-Generated Force to Clear the Mesothelium
    Cancer Discov December 1 2011 1 (7) 626-626; DOI:10.1158/2159-8290.CD-11-0279

  • Correction
    Correction: Forty Years of Translational Cancer Research
    Cancer Discov December 1 2011 1 (7) 627-627; DOI:10.1158/2159-8290.CD-11-0296

  • Correction
    Correction: Drugs, Diagnostic Tests Approved Quickly
    Cancer Discov December 1 2011 1 (7) 627-627; DOI:10.1158/2159-8290.CD-11-0299

Acknowledgment to Reviewers

  • Acknowledgment to Reviewers
    Acknowledgment to Reviewers
    Cancer Discov December 1 2011 1 (7) 628-628; DOI:10.1158/2159-8290.CD-ACK121411

Back to top
PreviousNext
Cancer Discovery: 1 (7)
December 2011
Volume 1, Issue 7
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover

Sign up for alerts

Jump to

  • In This Issue
  • In the Spotlight
  • Review
  • Research Briefs
  • Research Articles
  • News in Brief
  • News in Depth
  • Research Watch
    • Chemotherapy
    • Drug Resistance
    • Hepatocellular Carcinoma
    • Immunotherapy
    • Metastasis
    • Oncogenes
    • Tumor Suppressors
    • Tumorigenesis
  • Corrections
  • Acknowledgment to Reviewers
Advertisement
  • Most Cited
  • Most Read
Loading
  • The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data
  • Macrophages Regulate Response to Chemotherapy
  • Core Resistance Mechanisms and Genetic Evolution of Melanoma under BRAF Inhibitor Selection
  • EGFR Mediates RAF Inhibitor Resistance in BRAF-Mutant Colorectal Cancer
  • PDX Models in Cancer Research
More...
  • Home
  • Alerts
  • Feedback
  • Privacy Policy
Facebook   Twitter   LinkedIn   YouTube   RSS

Articles

  • OnlineFirst
  • Current Issue
  • Past Issues

Info For

  • Authors
  • Subscribers
  • Advertisers
  • Librarians

About Cancer Discovery

  • About the Journal
  • Editors
  • Journal Sections
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2021 by the American Association for Cancer Research.

Cancer Discovery
eISSN: 2159-8290
ISSN: 2159-8274

Advertisement