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Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer

G. Aaron Hobbs, Nicole M. Baker, Anne M. Miermont, Ryan D. Thurman, Mariaelena Pierobon, Timothy H. Tran, Andrew O. Anderson, Andrew M. Waters, J. Nathaniel Diehl, Bjoern Papke, Richard G. Hodge, Jennifer E. Klomp, Craig M. Goodwin, Jonathan M. DeLiberty, Junning Wang, Raymond W.S. Ng, Prson Gautam, Kirsten L. Bryant, Dominic Esposito, Sharon L. Campbell, Emanuel F. Petricoin III, Dhirendra K. Simanshu, Andrew J. Aguirre, Brian M. Wolpin, Krister Wennerberg, Udo Rudloff, Adrienne D. Cox and Channing J. Der
G. Aaron Hobbs
1Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
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  • ORCID record for G. Aaron Hobbs
Nicole M. Baker
1Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
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  • ORCID record for Nicole M. Baker
Anne M. Miermont
2Thoracic and GI Oncology Branch, NCI, Bethesda, Maryland.
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Ryan D. Thurman
3Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
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Mariaelena Pierobon
4Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia.
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Timothy H. Tran
5NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland.
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Andrew O. Anderson
2Thoracic and GI Oncology Branch, NCI, Bethesda, Maryland.
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Andrew M. Waters
6Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
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  • ORCID record for Andrew M. Waters
J. Nathaniel Diehl
7Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
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Bjoern Papke
6Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
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  • ORCID record for Bjoern Papke
Richard G. Hodge
6Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
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  • ORCID record for Richard G. Hodge
Jennifer E. Klomp
6Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
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Craig M. Goodwin
6Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
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Jonathan M. DeLiberty
1Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
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Junning Wang
8Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Raymond W.S. Ng
8Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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  • ORCID record for Raymond W.S. Ng
Prson Gautam
9Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
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  • ORCID record for Prson Gautam
Kirsten L. Bryant
1Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
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  • ORCID record for Kirsten L. Bryant
Dominic Esposito
5NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland.
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Sharon L. Campbell
3Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
6Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
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Emanuel F. Petricoin III
4Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia.
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Dhirendra K. Simanshu
5NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland.
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Andrew J. Aguirre
8Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
10Broad Institute of MIT and Harvard, Cambridge, Massachusetts.
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Brian M. Wolpin
8Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Krister Wennerberg
9Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
11Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark.
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Udo Rudloff
2Thoracic and GI Oncology Branch, NCI, Bethesda, Maryland.
12Rare Tumor Initiative, Pediatric Oncology Branch, NCI, Bethesda, Maryland.
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  • For correspondence: cjder@med.unc.edu rudloffu@mail.nih.gov
Adrienne D. Cox
1Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
6Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
13Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
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Channing J. Der
1Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
6Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
7Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
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  • For correspondence: cjder@med.unc.edu rudloffu@mail.nih.gov
DOI: 10.1158/2159-8290.CD-19-1006 Published January 2020
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Article Information

Volume 10, Issue 1, pp. 104-123

DOI 
https://doi.org/10.1158/2159-8290.CD-19-1006
PubMed 
31649109

Published By 
American Association for Cancer Research
Print ISSN 
2159-8274
Online ISSN 
2159-8290
History 
  • Received August 30, 2019
  • Revision received October 17, 2019
  • Accepted October 18, 2019
  • Published first October 24, 2019.

Article Versions

  • Previous version (October 24, 2019 - 06:10).
  • Previous version (December 18, 2019 - 05:59).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2019 American Association for Cancer Research.

Author Information

  1. G. Aaron Hobbs1,
  2. Nicole M. Baker1,
  3. Anne M. Miermont2,
  4. Ryan D. Thurman3,
  5. Mariaelena Pierobon4,
  6. Timothy H. Tran5,
  7. Andrew O. Anderson2,
  8. Andrew M. Waters6,
  9. J. Nathaniel Diehl7,
  10. Bjoern Papke6,
  11. Richard G. Hodge6,
  12. Jennifer E. Klomp6,
  13. Craig M. Goodwin6,
  14. Jonathan M. DeLiberty1,
  15. Junning Wang8,
  16. Raymond W.S. Ng8,
  17. Prson Gautam9,
  18. Kirsten L. Bryant1,
  19. Dominic Esposito5,
  20. Sharon L. Campbell3,6,
  21. Emanuel F. Petricoin III4,
  22. Dhirendra K. Simanshu5,
  23. Andrew J. Aguirre8,10,
  24. Brian M. Wolpin8,
  25. Krister Wennerberg9,11,
  26. Udo Rudloff2,12,*,
  27. Adrienne D. Cox1,6,13 and
  28. Channing J. Der1,6,7,*
  1. 1Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
  2. 2Thoracic and GI Oncology Branch, NCI, Bethesda, Maryland.
  3. 3Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
  4. 4Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia.
  5. 5NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland.
  6. 6Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
  7. 7Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
  8. 8Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  9. 9Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
  10. 10Broad Institute of MIT and Harvard, Cambridge, Massachusetts.
  11. 11Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark.
  12. 12Rare Tumor Initiative, Pediatric Oncology Branch, NCI, Bethesda, Maryland.
  13. 13Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
  1. ↵*Corresponding Authors:
    Channing J. Der, University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, CB7295, Chapel Hill, NC 27599-7295. Phone: 919-966-5634; Fax: 919-966-9673; E-mail: cjder{at}med.unc.edu; and Udo Rudloff, Center for Cancer Research, NCI, Building 10, Hatfield CRC, Room 2B-34D, Bethesda, MD 20892. Phone: 240-760-6238; E-mail: rudloffu{at}mail.nih.gov
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Cancer Discovery: 10 (1)
January 2020
Volume 10, Issue 1
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Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer
G. Aaron Hobbs, Nicole M. Baker, Anne M. Miermont, Ryan D. Thurman, Mariaelena Pierobon, Timothy H. Tran, Andrew O. Anderson, Andrew M. Waters, J. Nathaniel Diehl, Bjoern Papke, Richard G. Hodge, Jennifer E. Klomp, Craig M. Goodwin, Jonathan M. DeLiberty, Junning Wang, Raymond W.S. Ng, Prson Gautam, Kirsten L. Bryant, Dominic Esposito, Sharon L. Campbell, Emanuel F. Petricoin III, Dhirendra K. Simanshu, Andrew J. Aguirre, Brian M. Wolpin, Krister Wennerberg, Udo Rudloff, Adrienne D. Cox and Channing J. Der
Cancer Discov January 1 2020 (10) (1) 104-123; DOI: 10.1158/2159-8290.CD-19-1006

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Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer
G. Aaron Hobbs, Nicole M. Baker, Anne M. Miermont, Ryan D. Thurman, Mariaelena Pierobon, Timothy H. Tran, Andrew O. Anderson, Andrew M. Waters, J. Nathaniel Diehl, Bjoern Papke, Richard G. Hodge, Jennifer E. Klomp, Craig M. Goodwin, Jonathan M. DeLiberty, Junning Wang, Raymond W.S. Ng, Prson Gautam, Kirsten L. Bryant, Dominic Esposito, Sharon L. Campbell, Emanuel F. Petricoin III, Dhirendra K. Simanshu, Andrew J. Aguirre, Brian M. Wolpin, Krister Wennerberg, Udo Rudloff, Adrienne D. Cox and Channing J. Der
Cancer Discov January 1 2020 (10) (1) 104-123; DOI: 10.1158/2159-8290.CD-19-1006
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