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Cancer Discovery
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Precision Prevention and Cancer Interception: The New Challenges of Liquid Biopsy

Maria Jose Serrano, Maria Carmen Garrido-Navas, Juan Jose Diaz Mochon, Massimo Cristofanilli, Ignacio Gil-Bazo, Patrick Pauwels, Umberto Malapelle, Alessandro Russo, Jose A. Lorente, Antonio J. Ruiz-Rodriguez, Luis G. Paz-Ares, Eduardo Vilar, Luis E. Raez, Andres F. Cardona and Christian Rolfo; on behalf of the International Society of Liquid Biopsy
Maria Jose Serrano
1GENYO Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, Spain.
2Bio-Health Research Institute (Instituto de Investigación Biosanitaria ibs. GRANADA), Hospital Universitario Virgen de las Nieves Granada, Department of Medical Oncology, University of Granada, Granada, Spain.
3Department of Pathological Anatomy, Faculty of Medicine, Campus de Ciencias de la Salud, University of Granada, Granada, Spain.
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  • ORCID record for Maria Jose Serrano
  • For correspondence: christian.rolfo@umm.edu mjose.serrano@genyo.es
Maria Carmen Garrido-Navas
1GENYO Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, Spain.
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Juan Jose Diaz Mochon
1GENYO Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, Spain.
4DestiNA Genomica S.L. Parque Tecnológico Ciencias de la Salud (PTS), Armilla, Granada, Spain.
5Department of Medicinal and Organic Chemistry, School of Pharmacy, University of Granada, Granada, Spain.
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Massimo Cristofanilli
6Department of Medicine, Division of Hematology and Oncology, Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
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Ignacio Gil-Bazo
7Department of Oncology, Clínica Universidad de Navarra, Pamplona, Spain.
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Patrick Pauwels
8Department of Pathology, University Hospital Antwerp, Belgium & Center for Oncological Research (CORE), Antwerp University, Belgium.
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Umberto Malapelle
9Department of Public Health, University of Naples “Federico II,” Naples, Italy.
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Alessandro Russo
10Medical Oncology Unit, A.O. Papardo, Messina, Italy.
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Jose A. Lorente
1GENYO Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, Spain.
11Laboratory of Genetic Identification, Department of Legal Medicine, University of Granada, Granada, Spain.
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Antonio J. Ruiz-Rodriguez
12Unit of gastroenterology and hepatology, University Hospital Clínico San Cecilio, Granada, Spain.
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Luis G. Paz-Ares
13Division of Medical Oncology, University Hospital 12 de Octubre, Madrid, Spain.
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Eduardo Vilar
14Department of Clinical Cancer Prevention, Division of OVP, Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Luis E. Raez
15Memorial Cancer Institute, Memorial Health Care System, Florida International University, Miami, Florida.
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Andres F. Cardona
16Clinical and Translational Oncology Group, Clínica del Country, Bogotá, Colombia.
17Foundation for Clinical and Applied Cancer Research –FICMAC, Bogotá, Colombia.
18Molecular Oncology and Biology Systems Research Group (Fox-G), Universidad El Bosque, Bogotá, Colombia.
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Christian Rolfo
19Thoracic Oncology & Experimental Therapeutics Program, Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland.
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  • For correspondence: christian.rolfo@umm.edu mjose.serrano@genyo.es
DOI: 10.1158/2159-8290.CD-20-0466 Published November 2020
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Abstract

Despite major therapeutic progress, most advanced solid tumors are still incurable. Cancer interception is the active way to combat cancer onset, and development of this approach within high-risk populations seems a logical first step. Until now, strategies for the identification of high-risk subjects have been based on low-sensitivity and low-specificity assays. However, new liquid biopsy assays, “the Rosetta Stone of the new biomedicine era,” with the ability to identify circulating biomarkers with unprecedented sensitivity, promise to revolutionize cancer management. This review focuses on novel liquid biopsy approaches and the applications to cancer interception. Cancer interception involves the identification of biomarkers associated with developing cancer, and includes genetic and epigenetic alterations, as well as circulating tumor cells and circulating epithelial cells in individuals at risk, and the implementation of therapeutic strategies to prevent the beginning of cancer and to stop its development. Large prospective studies are needed to confirm the potential role of liquid biopsy for early detection of precancer lesions and tumors.

Footnotes

  • Cancer Discov 2020;10:1635–44

  • Received April 12, 2020.
  • Revision received June 22, 2020.
  • Accepted August 5, 2020.
  • Published first October 9, 2020.
  • ©2020 American Association for Cancer Research.
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Cancer Discovery: 10 (11)
November 2020
Volume 10, Issue 11
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Precision Prevention and Cancer Interception: The New Challenges of Liquid Biopsy
Maria Jose Serrano, Maria Carmen Garrido-Navas, Juan Jose Diaz Mochon, Massimo Cristofanilli, Ignacio Gil-Bazo, Patrick Pauwels, Umberto Malapelle, Alessandro Russo, Jose A. Lorente, Antonio J. Ruiz-Rodriguez, Luis G. Paz-Ares, Eduardo Vilar, Luis E. Raez, Andres F. Cardona and Christian Rolfo on behalf of the International Society of Liquid Biopsy
Cancer Discov November 1 2020 (10) (11) 1635-1644; DOI: 10.1158/2159-8290.CD-20-0466

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Precision Prevention and Cancer Interception: The New Challenges of Liquid Biopsy
Maria Jose Serrano, Maria Carmen Garrido-Navas, Juan Jose Diaz Mochon, Massimo Cristofanilli, Ignacio Gil-Bazo, Patrick Pauwels, Umberto Malapelle, Alessandro Russo, Jose A. Lorente, Antonio J. Ruiz-Rodriguez, Luis G. Paz-Ares, Eduardo Vilar, Luis E. Raez, Andres F. Cardona and Christian Rolfo on behalf of the International Society of Liquid Biopsy
Cancer Discov November 1 2020 (10) (11) 1635-1644; DOI: 10.1158/2159-8290.CD-20-0466
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