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Abstract
Summary: Song and colleagues describe how N-glycans stabilize expression of checkpoint molecule B7-H4 that suppresses T-cell function. Inhibiting N-glycan stabilization of B7-H4 generates an immune hot cancer that is more responsive to combination therapies.
See related article by Song et al., p. 1872.
Footnotes
Cancer Discov 2020;10:1789–90
- ©2020 American Association for Cancer Research.
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December 2020
Volume 10, Issue 12
Volume 10, Issue 12
A Sweet Approach to Heat Up Cancer Response to Immunotherapy
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