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Abstract
In low-grade gliomas, mutant forms of IDH1/2 trigger expression of tau, a protein typically associated with neurodegenerative disease that also inhibits EGFR signaling to impede tumor progression. The new findings provide a scientific rationale for pharmacologically mimicking the function of tau with microtubule-stabilizing drugs for the treatment of brain tumors.
- ©2020 American Association for Cancer Research.
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March 2020
Volume 10, Issue 3
Volume 10, Issue 3
Alzheimer-Related Protein Suppresses Gliomas
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