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Research Brief

Patients with Cancer Appear More Vulnerable to SARS-CoV-2: A Multicenter Study during the COVID-19 Outbreak

Mengyuan Dai, Dianbo Liu, Miao Liu, Fuxiang Zhou, Guiling Li, Zhen Chen, Zhian Zhang, Hua You, Meng Wu, Qichao Zheng, Yong Xiong, Huihua Xiong, Chun Wang, Changchun Chen, Fei Xiong, Yan Zhang, Yaqin Peng, Siping Ge, Bo Zhen, Tingting Yu, Ling Wang, Hua Wang, Yu Liu, Yeshan Chen, Junhua Mei, Xiaojia Gao, Zhuyan Li, Lijuan Gan, Can He, Zhen Li, Yuying Shi, Yuwen Qi, Jing Yang, Daniel G. Tenen, Li Chai, Lorelei A. Mucci, Mauricio Santillana and Hongbing Cai
Mengyuan Dai
1Department of Gynecological Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
2Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China.
3Hubei Cancer Clinical Study Center, Wuhan, China.
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Dianbo Liu
4Computational Health Informatics Program, Boston Children's Hospital, Boston, Massachusetts.
5Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.
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Miao Liu
6Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
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  • For correspondence: chb21051@163.com msantill@g.harvard.edu mliu0@bwh.harvard.edu
Fuxiang Zhou
2Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China.
3Hubei Cancer Clinical Study Center, Wuhan, China.
7Department of Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
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Guiling Li
8Cancer Center, Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.
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Zhen Chen
9Department of Emergency, The Central Hospital of Wuhan affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.
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Zhian Zhang
10Department of Gynecology, The Central Hospital of Huanggang, Huanggang, Hubei, China
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Hua You
11Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, Guangdong Province, China.
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Meng Wu
12Department of Ultrasound, Zhongnan Hospital of Wuhan University, Wuhan, China.
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Qichao Zheng
12Department of Ultrasound, Zhongnan Hospital of Wuhan University, Wuhan, China.
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Yong Xiong
13Department of Infectious Disease, Zhongnan Hospital of Wuhan University, Wuhan, China.
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  • ORCID record for Yong Xiong
Huihua Xiong
14Cancer Center, Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.
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Chun Wang
15Department of Oncology, The Central Hospital of Wuhan affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.
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Changchun Chen
16Department of Radiology, Hubei Cancer Hospital, Wuhan, Hubei, China.
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Fei Xiong
17Department of Thoracic Surgery, Hubei Cancer Hospital, Wuhan, Hubei, China.
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Yan Zhang
18Department of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, China.
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Yaqin Peng
18Department of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, China.
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Siping Ge
19Department of Oncology, Wuhan Puren Hospital, Wuhan, Hubei, China.
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Bo Zhen
20Department of Obstetrics and Gynecology, The Central Hospital of Xianning, Xianning, Hubei, China.
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Tingting Yu
21Department of Oncology, The Central Hospital of Xiaogan, Xiaogan, China.
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Ling Wang
22Department of Obstetrics and Gynecology, The People's Hospital of Huangmei, Huangmei, Hubei, China.
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Hua Wang
23Department of Obstetrics and Gynecology, Xiangyang First People's Hospital affiliated to Hubei University of Medicine, Xiangyang, Hubei, China.
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Yu Liu
2Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China.
3Hubei Cancer Clinical Study Center, Wuhan, China.
7Department of Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
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Yeshan Chen
8Cancer Center, Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.
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Junhua Mei
10Department of Gynecology, The Central Hospital of Huanggang, Huanggang, Hubei, China
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Xiaojia Gao
15Department of Oncology, The Central Hospital of Wuhan affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.
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Zhuyan Li
24Department of Obstetrics and Gynecology, The People's Hospital of Shiyan, Shiyan, Hubei, China.
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Lijuan Gan
1Department of Gynecological Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
2Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China.
3Hubei Cancer Clinical Study Center, Wuhan, China.
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Can He
1Department of Gynecological Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
2Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China.
3Hubei Cancer Clinical Study Center, Wuhan, China.
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Zhen Li
1Department of Gynecological Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
2Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China.
3Hubei Cancer Clinical Study Center, Wuhan, China.
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Yuying Shi
1Department of Gynecological Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
2Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China.
3Hubei Cancer Clinical Study Center, Wuhan, China.
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Yuwen Qi
1Department of Gynecological Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
2Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China.
3Hubei Cancer Clinical Study Center, Wuhan, China.
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Jing Yang
1Department of Gynecological Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
2Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China.
3Hubei Cancer Clinical Study Center, Wuhan, China.
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Daniel G. Tenen
25Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts.
26Cancer Science Institute of Singapore, National University of Singapore, Singapore.
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Li Chai
6Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
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Lorelei A. Mucci
27Harvard T.H. Chan School of Public Health, Dana-Farber, Harvard Cancer Center, Boston, Massachusetts.
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Mauricio Santillana
4Computational Health Informatics Program, Boston Children's Hospital, Boston, Massachusetts.
5Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.
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  • For correspondence: chb21051@163.com msantill@g.harvard.edu mliu0@bwh.harvard.edu
Hongbing Cai
1Department of Gynecological Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
2Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China.
3Hubei Cancer Clinical Study Center, Wuhan, China.
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  • For correspondence: chb21051@163.com msantill@g.harvard.edu mliu0@bwh.harvard.edu
DOI: 10.1158/2159-8290.CD-20-0422 Published June 2020
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Abstract

The novel COVID-19 outbreak has affected more than 200 countries and territories as of March 2020. Given that patients with cancer are generally more vulnerable to infections, systematic analysis of diverse cohorts of patients with cancer affected by COVID-19 is needed. We performed a multicenter study including 105 patients with cancer and 536 age-matched noncancer patients confirmed with COVID-19. Our results showed COVID-19 patients with cancer had higher risks in all severe outcomes. Patients with hematologic cancer, lung cancer, or with metastatic cancer (stage IV) had the highest frequency of severe events. Patients with nonmetastatic cancer experienced similar frequencies of severe conditions to those observed in patients without cancer. Patients who received surgery had higher risks of having severe events, whereas patients who underwent only radiotherapy did not demonstrate significant differences in severe events when compared with patients without cancer. These findings indicate that patients with cancer appear more vulnerable to SARS-CoV-2 outbreak.

Significance: Because this is the first large cohort study on this topic, our report will provide much-needed information that will benefit patients with cancer globally. As such, we believe it is extremely important that our study be disseminated widely to alert clinicians and patients.

This article is highlighted in the In This Issue feature, p. 747

Footnotes

  • Note: Supplementary data for this article are available at Cancer Discovery Online (http://cancerdiscovery.aacrjournals.org/).

  • Cancer Discov 2020;10:783–91

  • Received April 2, 2020.
  • Revision received April 16, 2020.
  • Accepted April 23, 2020.
  • Published first April 28, 2020.
  • ©2020 American Association for Cancer Research.
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Cancer Discovery: 10 (6)
June 2020
Volume 10, Issue 6
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Patients with Cancer Appear More Vulnerable to SARS-CoV-2: A Multicenter Study during the COVID-19 Outbreak
Mengyuan Dai, Dianbo Liu, Miao Liu, Fuxiang Zhou, Guiling Li, Zhen Chen, Zhian Zhang, Hua You, Meng Wu, Qichao Zheng, Yong Xiong, Huihua Xiong, Chun Wang, Changchun Chen, Fei Xiong, Yan Zhang, Yaqin Peng, Siping Ge, Bo Zhen, Tingting Yu, Ling Wang, Hua Wang, Yu Liu, Yeshan Chen, Junhua Mei, Xiaojia Gao, Zhuyan Li, Lijuan Gan, Can He, Zhen Li, Yuying Shi, Yuwen Qi, Jing Yang, Daniel G. Tenen, Li Chai, Lorelei A. Mucci, Mauricio Santillana and Hongbing Cai
Cancer Discov June 1 2020 (10) (6) 783-791; DOI: 10.1158/2159-8290.CD-20-0422

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Patients with Cancer Appear More Vulnerable to SARS-CoV-2: A Multicenter Study during the COVID-19 Outbreak
Mengyuan Dai, Dianbo Liu, Miao Liu, Fuxiang Zhou, Guiling Li, Zhen Chen, Zhian Zhang, Hua You, Meng Wu, Qichao Zheng, Yong Xiong, Huihua Xiong, Chun Wang, Changchun Chen, Fei Xiong, Yan Zhang, Yaqin Peng, Siping Ge, Bo Zhen, Tingting Yu, Ling Wang, Hua Wang, Yu Liu, Yeshan Chen, Junhua Mei, Xiaojia Gao, Zhuyan Li, Lijuan Gan, Can He, Zhen Li, Yuying Shi, Yuwen Qi, Jing Yang, Daniel G. Tenen, Li Chai, Lorelei A. Mucci, Mauricio Santillana and Hongbing Cai
Cancer Discov June 1 2020 (10) (6) 783-791; DOI: 10.1158/2159-8290.CD-20-0422
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