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Cancer Discovery
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Mutations in the RNA Splicing Factor SF3B1 Promote Tumorigenesis through MYC Stabilization

Zhaoqi Liu, Akihide Yoshimi, Jiguang Wang, Hana Cho, Stanley Chun-Wei Lee, Michelle Ki, Lillian Bitner, Timothy Chu, Harshal Shah, Bo Liu, Anthony R. Mato, Peter Ruvolo, Giulia Fabbri, Laura Pasqualucci, Omar Abdel-Wahab and Raul Rabadan
Zhaoqi Liu
1Program for Mathematical Genomics, Columbia University, New York, New York.
2Departments of Systems Biology and Biomedical Informatics, Columbia University, New York, New York.
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Akihide Yoshimi
3Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
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  • ORCID record for Akihide Yoshimi
  • For correspondence: rr2579@cumc.columbia.edu yoshimia@mskcc.org
Jiguang Wang
4Division of Life Science, Department of Chemical and Biological Engineering, Center for Systems Biology and Human Health and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong SAR, China.
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Hana Cho
3Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
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Stanley Chun-Wei Lee
3Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
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Michelle Ki
3Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
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Lillian Bitner
3Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
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Timothy Chu
1Program for Mathematical Genomics, Columbia University, New York, New York.
2Departments of Systems Biology and Biomedical Informatics, Columbia University, New York, New York.
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Harshal Shah
3Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
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Bo Liu
3Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
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Anthony R. Mato
5Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
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Peter Ruvolo
6Division of Cancer Medicine, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Giulia Fabbri
7Institute for Cancer Genetics, Columbia University, New York, New York.
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Laura Pasqualucci
7Institute for Cancer Genetics, Columbia University, New York, New York.
8Department of Pathology and Cell Biology, and the Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York.
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Omar Abdel-Wahab
3Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
5Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
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Raul Rabadan
1Program for Mathematical Genomics, Columbia University, New York, New York.
2Departments of Systems Biology and Biomedical Informatics, Columbia University, New York, New York.
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  • For correspondence: rr2579@cumc.columbia.edu yoshimia@mskcc.org
DOI: 10.1158/2159-8290.CD-19-1330 Published June 2020
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Article Information

Volume 10, Issue 6, pp. 806-821

DOI 
https://doi.org/10.1158/2159-8290.CD-19-1330
PubMed 
32188705

Published By 
American Association for Cancer Research
Print ISSN 
2159-8274
Online ISSN 
2159-8290
History 
  • Received November 14, 2019
  • Revision received February 15, 2020
  • Accepted March 12, 2020
  • Published first March 18, 2020.

Article Versions

  • Previous version (March 18, 2020 - 06:11).
  • Previous version (May 12, 2020 - 06:01).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2020 American Association for Cancer Research.

Author Information

  1. Zhaoqi Liu1,2,#,
  2. Akihide Yoshimi3,#,*,
  3. Jiguang Wang4,
  4. Hana Cho3,
  5. Stanley Chun-Wei Lee3,
  6. Michelle Ki3,
  7. Lillian Bitner3,
  8. Timothy Chu1,2,
  9. Harshal Shah3,
  10. Bo Liu3,
  11. Anthony R. Mato5,
  12. Peter Ruvolo6,
  13. Giulia Fabbri7,
  14. Laura Pasqualucci7,8,
  15. Omar Abdel-Wahab3,5 and
  16. Raul Rabadan1,2,*
  1. 1Program for Mathematical Genomics, Columbia University, New York, New York.
  2. 2Departments of Systems Biology and Biomedical Informatics, Columbia University, New York, New York.
  3. 3Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
  4. 4Division of Life Science, Department of Chemical and Biological Engineering, Center for Systems Biology and Human Health and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong SAR, China.
  5. 5Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
  6. 6Division of Cancer Medicine, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  7. 7Institute for Cancer Genetics, Columbia University, New York, New York.
  8. 8Department of Pathology and Cell Biology, and the Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York.
  1. ↵*Corresponding Authors:
    Raul Rabadan, Columbia University Irving Medical Center, 622 West 168th Street, PH18-200, New York, NY 10032. Phone: 212-305-3896; Fax: 212-851-5149; E-mail: rr2579{at}cumc.columbia.edu; and Akihide Yoshimi, Memorial Sloan Kettering Cancer Center, Zuckerman Research Building, 417 E. 68th Street, New York, NY 10065. Phone: 646-888-3242; Fax: 646-422-0890; E-mail: yoshimia{at}mskcc.org
  1. ↵#Z. Liu and A. Yoshimi share first authorship of this article.

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Cancer Discovery: 10 (6)
June 2020
Volume 10, Issue 6
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Mutations in the RNA Splicing Factor SF3B1 Promote Tumorigenesis through MYC Stabilization
Zhaoqi Liu, Akihide Yoshimi, Jiguang Wang, Hana Cho, Stanley Chun-Wei Lee, Michelle Ki, Lillian Bitner, Timothy Chu, Harshal Shah, Bo Liu, Anthony R. Mato, Peter Ruvolo, Giulia Fabbri, Laura Pasqualucci, Omar Abdel-Wahab and Raul Rabadan
Cancer Discov June 1 2020 (10) (6) 806-821; DOI: 10.1158/2159-8290.CD-19-1330

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Mutations in the RNA Splicing Factor SF3B1 Promote Tumorigenesis through MYC Stabilization
Zhaoqi Liu, Akihide Yoshimi, Jiguang Wang, Hana Cho, Stanley Chun-Wei Lee, Michelle Ki, Lillian Bitner, Timothy Chu, Harshal Shah, Bo Liu, Anthony R. Mato, Peter Ruvolo, Giulia Fabbri, Laura Pasqualucci, Omar Abdel-Wahab and Raul Rabadan
Cancer Discov June 1 2020 (10) (6) 806-821; DOI: 10.1158/2159-8290.CD-19-1330
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