Mutations in the RNA Splicing Factor SF3B1 Promote Tumorigenesis through MYC Stabilization

1Program for Mathematical Genomics, Columbia University, New York, New York.

2Departments of Systems Biology and Biomedical Informatics, Columbia University, New York, New York.

3Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

4Division of Life Science, Department of Chemical and Biological Engineering, Center for Systems Biology and Human Health and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong SAR, China.

3Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

3Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

3Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

3Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

1Program for Mathematical Genomics, Columbia University, New York, New York.

2Departments of Systems Biology and Biomedical Informatics, Columbia University, New York, New York.

3Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

3Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

5Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

6Division of Cancer Medicine, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.

7Institute for Cancer Genetics, Columbia University, New York, New York.

7Institute for Cancer Genetics, Columbia University, New York, New York.

8Department of Pathology and Cell Biology, and the Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York.

3Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.

5Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

1Program for Mathematical Genomics, Columbia University, New York, New York.

2Departments of Systems Biology and Biomedical Informatics, Columbia University, New York, New York.