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Golgi Acidification by NHE7 Regulates Cytosolic pH Homeostasis in Pancreatic Cancer Cells

Koen M.O. Galenkamp, Paulina Sosicka, Michael Jung, M. Victoria Recouvreux, Yijuan Zhang, Matthew R. Moldenhauer, Giovanni Brandi, Hudson H. Freeze and Cosimo Commisso
Koen M.O. Galenkamp
1Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California.
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  • ORCID record for Koen M.O. Galenkamp
Paulina Sosicka
2Human Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California.
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Michael Jung
1Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California.
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M. Victoria Recouvreux
1Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California.
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Yijuan Zhang
1Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California.
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Matthew R. Moldenhauer
1Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California.
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Giovanni Brandi
3Department of Experimental, Diagnostic, and Specialty Medicine, S. Orsola-Malpighi University Hospital, Bologna, Italy.
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Hudson H. Freeze
2Human Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California.
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Cosimo Commisso
1Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California.
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  • For correspondence: ccommisso@sbpdiscovery.org
DOI: 10.1158/2159-8290.CD-19-1007 Published June 2020
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Article Information

Volume 10, Issue 6, pp. 822-835

DOI 
https://doi.org/10.1158/2159-8290.CD-19-1007
PubMed 
32200349

Published By 
American Association for Cancer Research
Print ISSN 
2159-8274
Online ISSN 
2159-8290
History 
  • Received August 29, 2019
  • Revision received February 7, 2020
  • Accepted March 18, 2020
  • Published first March 21, 2020.

Article Versions

  • Previous version (March 21, 2020 - 06:38).
  • Previous version (May 11, 2020 - 05:54).
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Copyright & Usage 
©2020 American Association for Cancer Research.

Author Information

  1. Koen M.O. Galenkamp1,
  2. Paulina Sosicka2,
  3. Michael Jung1,
  4. M. Victoria Recouvreux1,
  5. Yijuan Zhang1,
  6. Matthew R. Moldenhauer1,
  7. Giovanni Brandi3,
  8. Hudson H. Freeze2 and
  9. Cosimo Commisso1,*
  1. 1Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California.
  2. 2Human Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California.
  3. 3Department of Experimental, Diagnostic, and Specialty Medicine, S. Orsola-Malpighi University Hospital, Bologna, Italy.
  1. ↵*Corresponding Author:
    Cosimo Commisso, Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037. Phone: 858-795-5171; E-mail: ccommisso{at}sbpdiscovery.org
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Cancer Discovery: 10 (6)
June 2020
Volume 10, Issue 6
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Golgi Acidification by NHE7 Regulates Cytosolic pH Homeostasis in Pancreatic Cancer Cells
Koen M.O. Galenkamp, Paulina Sosicka, Michael Jung, M. Victoria Recouvreux, Yijuan Zhang, Matthew R. Moldenhauer, Giovanni Brandi, Hudson H. Freeze and Cosimo Commisso
Cancer Discov June 1 2020 (10) (6) 822-835; DOI: 10.1158/2159-8290.CD-19-1007

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Golgi Acidification by NHE7 Regulates Cytosolic pH Homeostasis in Pancreatic Cancer Cells
Koen M.O. Galenkamp, Paulina Sosicka, Michael Jung, M. Victoria Recouvreux, Yijuan Zhang, Matthew R. Moldenhauer, Giovanni Brandi, Hudson H. Freeze and Cosimo Commisso
Cancer Discov June 1 2020 (10) (6) 822-835; DOI: 10.1158/2159-8290.CD-19-1007
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