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Repression of the Type I Interferon Pathway Underlies MYC- and KRAS-Dependent Evasion of NK and B Cells in Pancreatic Ductal Adenocarcinoma

Nathiya Muthalagu, Tiziana Monteverde, Ximena Raffo-Iraolagoitia, Robert Wiesheu, Declan Whyte, Ann Hedley, Sarah Laing, Björn Kruspig, Rosanna Upstill-Goddard, Robin Shaw, Sarah Neidler, Curtis Rink, Saadia A. Karim, Katarina Gyuraszova, Colin Nixon, William Clark, Andrew V. Biankin, Leo M. Carlin, Seth B. Coffelt, Owen J. Sansom, Jennifer P. Morton and Daniel J. Murphy
Nathiya Muthalagu
1CRUK Beatson Institute, Glasgow, Scotland, United Kingdom.
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Tiziana Monteverde
2Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom.
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  • ORCID record for Tiziana Monteverde
Ximena Raffo-Iraolagoitia
1CRUK Beatson Institute, Glasgow, Scotland, United Kingdom.
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Robert Wiesheu
2Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom.
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  • ORCID record for Robert Wiesheu
Declan Whyte
2Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom.
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Ann Hedley
1CRUK Beatson Institute, Glasgow, Scotland, United Kingdom.
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Sarah Laing
2Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom.
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  • ORCID record for Sarah Laing
Björn Kruspig
2Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom.
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Rosanna Upstill-Goddard
3Wolfson Wohl Translational Cancer Research Centre, University of Glasgow, Glasgow, Scotland, United Kingdom.
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  • ORCID record for Rosanna Upstill-Goddard
Robin Shaw
1CRUK Beatson Institute, Glasgow, Scotland, United Kingdom.
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Sarah Neidler
2Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom.
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  • ORCID record for Sarah Neidler
Curtis Rink
1CRUK Beatson Institute, Glasgow, Scotland, United Kingdom.
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Saadia A. Karim
1CRUK Beatson Institute, Glasgow, Scotland, United Kingdom.
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Katarina Gyuraszova
2Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom.
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Colin Nixon
1CRUK Beatson Institute, Glasgow, Scotland, United Kingdom.
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William Clark
1CRUK Beatson Institute, Glasgow, Scotland, United Kingdom.
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Andrew V. Biankin
3Wolfson Wohl Translational Cancer Research Centre, University of Glasgow, Glasgow, Scotland, United Kingdom.
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  • ORCID record for Andrew V. Biankin
Leo M. Carlin
1CRUK Beatson Institute, Glasgow, Scotland, United Kingdom.
2Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom.
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Seth B. Coffelt
1CRUK Beatson Institute, Glasgow, Scotland, United Kingdom.
2Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom.
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Owen J. Sansom
1CRUK Beatson Institute, Glasgow, Scotland, United Kingdom.
2Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom.
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Jennifer P. Morton
1CRUK Beatson Institute, Glasgow, Scotland, United Kingdom.
2Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom.
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  • For correspondence: daniel.murphy@glasgow.ac.uk Jennifer.morton@glasgow.ac.uk
Daniel J. Murphy
1CRUK Beatson Institute, Glasgow, Scotland, United Kingdom.
2Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom.
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  • For correspondence: daniel.murphy@glasgow.ac.uk Jennifer.morton@glasgow.ac.uk
DOI: 10.1158/2159-8290.CD-19-0620 Published June 2020
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Article Information

Volume 10, Issue 6, pp. 872-887

DOI 
https://doi.org/10.1158/2159-8290.CD-19-0620
PubMed 
32200350

Published By 
American Association for Cancer Research
Print ISSN 
2159-8274
Online ISSN 
2159-8290
History 
  • Received May 30, 2019
  • Revision received February 7, 2020
  • Accepted March 18, 2020
  • Published first March 21, 2020.

Article Versions

  • Previous version (March 21, 2020 - 06:38).
  • Previous version (May 11, 2020 - 05:54).
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©2020 American Association for Cancer Research.

Author Information

  1. Nathiya Muthalagu1,
  2. Tiziana Monteverde2,
  3. Ximena Raffo-Iraolagoitia1,
  4. Robert Wiesheu2,
  5. Declan Whyte2,
  6. Ann Hedley1,
  7. Sarah Laing2,
  8. Björn Kruspig2,
  9. Rosanna Upstill-Goddard3,
  10. Robin Shaw1,
  11. Sarah Neidler2,
  12. Curtis Rink1,
  13. Saadia A. Karim1,
  14. Katarina Gyuraszova2,
  15. Colin Nixon1,
  16. William Clark1,
  17. Andrew V. Biankin3,
  18. Leo M. Carlin1,2,
  19. Seth B. Coffelt1,2,
  20. Owen J. Sansom1,2,
  21. Jennifer P. Morton1,2,* and
  22. Daniel J. Murphy1,2,*
  1. 1CRUK Beatson Institute, Glasgow, Scotland, United Kingdom.
  2. 2Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom.
  3. 3Wolfson Wohl Translational Cancer Research Centre, University of Glasgow, Glasgow, Scotland, United Kingdom.
  1. ↵*Corresponding Authors:
    Daniel J. Murphy, University of Glasgow, CRUK Beatson Institute, Switchback Road, Glasgow, Scotland G61 1BD, United Kingdom. Phone: 44-141-330-8710; E-mail: daniel.murphy{at}glasgow.ac.uk; and Jennifer P. Morton, Phone: 44-141-330-2802; E-mail: Jennifer.morton{at}glasgow.ac.uk
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Cancer Discovery: 10 (6)
June 2020
Volume 10, Issue 6
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Repression of the Type I Interferon Pathway Underlies MYC- and KRAS-Dependent Evasion of NK and B Cells in Pancreatic Ductal Adenocarcinoma
Nathiya Muthalagu, Tiziana Monteverde, Ximena Raffo-Iraolagoitia, Robert Wiesheu, Declan Whyte, Ann Hedley, Sarah Laing, Björn Kruspig, Rosanna Upstill-Goddard, Robin Shaw, Sarah Neidler, Curtis Rink, Saadia A. Karim, Katarina Gyuraszova, Colin Nixon, William Clark, Andrew V. Biankin, Leo M. Carlin, Seth B. Coffelt, Owen J. Sansom, Jennifer P. Morton and Daniel J. Murphy
Cancer Discov June 1 2020 (10) (6) 872-887; DOI: 10.1158/2159-8290.CD-19-0620

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Repression of the Type I Interferon Pathway Underlies MYC- and KRAS-Dependent Evasion of NK and B Cells in Pancreatic Ductal Adenocarcinoma
Nathiya Muthalagu, Tiziana Monteverde, Ximena Raffo-Iraolagoitia, Robert Wiesheu, Declan Whyte, Ann Hedley, Sarah Laing, Björn Kruspig, Rosanna Upstill-Goddard, Robin Shaw, Sarah Neidler, Curtis Rink, Saadia A. Karim, Katarina Gyuraszova, Colin Nixon, William Clark, Andrew V. Biankin, Leo M. Carlin, Seth B. Coffelt, Owen J. Sansom, Jennifer P. Morton and Daniel J. Murphy
Cancer Discov June 1 2020 (10) (6) 872-887; DOI: 10.1158/2159-8290.CD-19-0620
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