Research Articles
Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes
Matthew Clarke, Alan Mackay, Britta Ismer, Jessica C. Pickles, Ruth G. Tatevossian, Scott Newman, Tejus A. Bale, Iris Stoler, Elisa Izquierdo, Sara Temelso, Diana M. Carvalho, Valeria Molinari, Anna Burford, Louise Howell, Alex Virasami, Amy R. Fairchild, Aimee Avery, Jane Chalker, Mark Kristiansen, Kelly Haupfear, James D. Dalton, Wilda Orisme, Ji Wen, Michael Hubank, Kathreena M. Kurian, Catherine Rowe, Mellissa Maybury, Stephen Crosier, Jeffrey Knipstein, Ulrich Schüller, Uwe Kordes, David E. Kram, Matija Snuderl, Leslie Bridges, Andrew J. Martin, Lawrence J. Doey, Safa Al-Sarraj, Christopher Chandler, Bassel Zebian, Claire Cairns, Rachael Natrajan, Jessica K.R. Boult, Simon P. Robinson, Martin Sill, Ira J. Dunkel, Stephen W. Gilheeney, Marc K. Rosenblum, Debbie Hughes, Paula Z. Proszek, Tobey J. Macdonald, Matthias Preusser, Christine Haberler, Irene Slavc, Roger Packer, Ho-Keung Ng, Shani Caspi, Mara Popović, Barbara Faganel Kotnik, Matthew D. Wood, Lissa Baird, Monika Ashok Davare, David A. Solomon, Thale Kristin Olsen, Petter Brandal, Michael Farrell, Jane B. Cryan, Michael Capra, Michael Karremann, Jens Schittenhelm, Martin U. Schuhmann, Martin Ebinger, Winand N.M. Dinjens, Kornelius Kerl, Simone Hettmer, Torsten Pietsch, Felipe Andreiuolo, Pablo Hernáiz Driever, Andrey Korshunov, Lotte Hiddingh, Barbara C. Worst, Dominik Sturm, Marc Zuckermann, Olaf Witt, Tabitha Bloom, Clare Mitchell, Evelina Miele, Giovanna Stefania Colafati, Francesca Diomedi-Camassei, Simon Bailey, Andrew S. Moore, Timothy E.G. Hassall, Stephen P. Lowis, Maria Tsoli, Mark J. Cowley, David S. Ziegler, Matthias A. Karajannis, Kristian Aquilina, Darren R. Hargrave, Fernando Carceller, Lynley V. Marshall, Andreas von Deimling, Christof M. Kramm, Stefan M. Pfister, Felix Sahm, Suzanne J. Baker, Angela Mastronuzzi, Andrea Carai, Maria Vinci, David Capper, Sergey Popov, David W. Ellison, Thomas S. Jacques, David T.W. Jones and Chris Jones
Matthew Clarke
1Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.
Alan Mackay
1Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.
Britta Ismer
2German Cancer Research Center (DKFZ), Heidelberg, Germany.
3Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.
4Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
Jessica C. Pickles
5UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
Ruth G. Tatevossian
6Department of Neuropathology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Scott Newman
7Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Tejus A. Bale
8Department of Neuropathology, Memorial Sloan-Kettering Cancer Center, New York, New York.
Iris Stoler
9Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Neuropathology, Berlin, Germany.
Elisa Izquierdo
1Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.
Sara Temelso
1Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.
Diana M. Carvalho
1Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.
Valeria Molinari
1Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.
Anna Burford
1Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.
Louise Howell
1Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.
Alex Virasami
5UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
Amy R. Fairchild
5UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
Aimee Avery
5UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
Jane Chalker
5UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
Mark Kristiansen
5UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
Kelly Haupfear
6Department of Neuropathology, St. Jude Children's Research Hospital, Memphis, Tennessee.
James D. Dalton
6Department of Neuropathology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Wilda Orisme
6Department of Neuropathology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Ji Wen
6Department of Neuropathology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Michael Hubank
10Molecular Diagnostics, Royal Marsden Hospital NHS Trust, Sutton, United Kingdom.
Kathreena M. Kurian
11Brain Tumour Research Centre, University of Bristol, Bristol, United Kingdom.
Catherine Rowe
11Brain Tumour Research Centre, University of Bristol, Bristol, United Kingdom.
Mellissa Maybury
12The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, Australia.
13Oncology Service, Queensland Children's Hospital, Brisbane, Australia.
14Child Health Research Centre, The University of Queensland, South Brisbane, Australia.
Stephen Crosier
15Newcastle Hospitals NHS Foundation Trust, Newcastle, United Kingdom.
Jeffrey Knipstein
16Division of Pediatric Hematology/Oncology/BMT, Medical College of Wisconsin, Milwaukee, Wisconsin.
Ulrich Schüller
17Department of Neuropathology, University Hospital Hamburg-Eppendorf, and Research Institute Children's Cancer Center, Hamburg, Germany.
18Pediatric Hematology and Oncology, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
Uwe Kordes
18Pediatric Hematology and Oncology, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
David E. Kram
19Section of Pediatric Hematology-Oncology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Matija Snuderl
20Department of Neuropathology, NYU Langone Health, New York, New York.
Leslie Bridges
21Department of Neuropathology, St George's Hospital NHS Trust, London, United Kingdom.
Andrew J. Martin
22Department of Neurosurgery, St George's Hospital NHS Trust, London, United Kingdom.
Lawrence J. Doey
23Department of Clinical Neuropathology, Kings College Hospital NHS Trust, London, United Kingdom.
Safa Al-Sarraj
23Department of Clinical Neuropathology, Kings College Hospital NHS Trust, London, United Kingdom.
Christopher Chandler
24Department of Neurosurgery, Kings College Hospital NHS Trust, London, United Kingdom.
Bassel Zebian
24Department of Neurosurgery, Kings College Hospital NHS Trust, London, United Kingdom.
Claire Cairns
24Department of Neurosurgery, Kings College Hospital NHS Trust, London, United Kingdom.
Rachael Natrajan
25The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom.
Jessica K.R. Boult
26Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, United Kingdom.
Simon P. Robinson
26Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, United Kingdom.
Martin Sill
2German Cancer Research Center (DKFZ), Heidelberg, Germany.
Ira J. Dunkel
27Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York.
Stephen W. Gilheeney
27Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York.
Marc K. Rosenblum
8Department of Neuropathology, Memorial Sloan-Kettering Cancer Center, New York, New York.
Debbie Hughes
10Molecular Diagnostics, Royal Marsden Hospital NHS Trust, Sutton, United Kingdom.
Paula Z. Proszek
10Molecular Diagnostics, Royal Marsden Hospital NHS Trust, Sutton, United Kingdom.
Tobey J. Macdonald
28Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia.
Matthias Preusser
29Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Christine Haberler
29Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
30Institute of Neurology, Medical University of Vienna, Vienna, Austria.
Irene Slavc
31Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.
Roger Packer
32Center for Neuroscience and Behavioural Medicine, Children's National Medical Center, Washington, DC.
Ho-Keung Ng
33Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, China.
Shani Caspi
34Cancer Research Center, Sheba Medical Center, Tel Aviv, Israel.
Mara Popović
35Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Barbara Faganel Kotnik
36Department of Hematology and Oncology, University Children's Hospital, Ljubljana, Slovenia.
Matthew D. Wood
37Department of Pathology, Oregon Health & Science University, Portland, Oregon.
Lissa Baird
38Department of Neurosurgery, Oregon Health & Science University, Portland, Oregon.
Monika Ashok Davare
39Department of Pediatrics, Oregon Health & Science University, Portland, Oregon.
David A. Solomon
40Department of Pathology, University of California, San Francisco, California.
41Clinical Cancer Genomics Laboratory, University of California, San Francisco, California.
Thale Kristin Olsen
42Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden.
Petter Brandal
43Department of Oncology, Oslo University Hospital, Oslo, Norway.
Michael Farrell
44Department of Histopathology, Beaumont Hospital, Dublin, Ireland.
Jane B. Cryan
44Department of Histopathology, Beaumont Hospital, Dublin, Ireland.
Michael Capra
45Paediatric Oncology, Our Lady's Children's Hospital, Dublin, Ireland.
Michael Karremann
46Department of Pediatrics, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Jens Schittenhelm
47Institute of Pathology and Neuropathology, University Hospital Tübingen, Germany.
Martin U. Schuhmann
48Department of Neurosurgery, University Hospital Tübingen, Germany.
Martin Ebinger
49Department of Pediatric Hematology and Oncology, University Hospital Tübingen, Germany.
Winand N.M. Dinjens
50Department of Pathology, Erasmus Medical Center, Rotterdam, the Netherlands.
Kornelius Kerl
51Department of Pediatric Hematology and Oncology, University Hospital Muenster, Germany.
Simone Hettmer
52Department of Pediatric Hematology and Oncology, University Hospital Freiburg, Germany.
Torsten Pietsch
53Institute of Neuropathology, DGNN Brain Tumor Reference Center, University of Bonn Medical Center, Bonn, Germany.
Felipe Andreiuolo
53Institute of Neuropathology, DGNN Brain Tumor Reference Center, University of Bonn Medical Center, Bonn, Germany.
Pablo Hernáiz Driever
54Department of Paediatric Haematology/Oncology Charité Universitätsmedizin, Berlin, Germany.
Andrey Korshunov
55Department of Neuropathology, University Hospital Heidelberg, Germany.
Lotte Hiddingh
2German Cancer Research Center (DKFZ), Heidelberg, Germany.
Barbara C. Worst
2German Cancer Research Center (DKFZ), Heidelberg, Germany.
4Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
56Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany.
Dominik Sturm
2German Cancer Research Center (DKFZ), Heidelberg, Germany.
4Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
56Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany.
Marc Zuckermann
2German Cancer Research Center (DKFZ), Heidelberg, Germany.
4Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
Olaf Witt
2German Cancer Research Center (DKFZ), Heidelberg, Germany.
4Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
56Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany.
Tabitha Bloom
57BRAIN UK, University of Southampton, Southampton, United Kingdom.
Clare Mitchell
57BRAIN UK, University of Southampton, Southampton, United Kingdom.
Evelina Miele
58Department of Onco-haematology, Cell and Gene Therapy, Bambino Gesù Children's Hospital-IRCCS, Rome, Italy.
Giovanna Stefania Colafati
59Oncological Neuroradiology Unit, Department of Diagnostic Imaging, Bambino Gesù Children's Hospital-IRCCS, Rome, Italy.
Francesca Diomedi-Camassei
60Department of Laboratories - Pathology Unit, Bambino Gesù Children's Hospital-IRCCS, Rome, Italy.
Simon Bailey
15Newcastle Hospitals NHS Foundation Trust, Newcastle, United Kingdom.
Andrew S. Moore
12The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, Australia.
13Oncology Service, Queensland Children's Hospital, Brisbane, Australia.
14Child Health Research Centre, The University of Queensland, South Brisbane, Australia.
Timothy E.G. Hassall
13Oncology Service, Queensland Children's Hospital, Brisbane, Australia.
61Institute for Molecular Bioscience, The University of Queensland, St Lucia, Australia.
62School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Australia.
Stephen P. Lowis
11Brain Tumour Research Centre, University of Bristol, Bristol, United Kingdom.
Maria Tsoli
63Children's Cancer Institute, University of New South Wales, Sydney, Australia.
64Kids Cancer Centre, Sydney Children's Hospital, Randwick, Australia.
Mark J. Cowley
63Children's Cancer Institute, University of New South Wales, Sydney, Australia.
64Kids Cancer Centre, Sydney Children's Hospital, Randwick, Australia.
David S. Ziegler
63Children's Cancer Institute, University of New South Wales, Sydney, Australia.
64Kids Cancer Centre, Sydney Children's Hospital, Randwick, Australia.
Matthias A. Karajannis
27Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York.
Kristian Aquilina
65Department of Neurosurgery, Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom.
Darren R. Hargrave
66Department of Paediatric Oncology, Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom.
Fernando Carceller
67Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom.
68Children & Young People's Unit, Royal Marsden Hospital NHS Trust, Sutton, United Kingdom.
Lynley V. Marshall
67Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom.
68Children & Young People's Unit, Royal Marsden Hospital NHS Trust, Sutton, United Kingdom.
Andreas von Deimling
55Department of Neuropathology, University Hospital Heidelberg, Germany.
69Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Christof M. Kramm
70Division of Pediatric Hematology and Oncology, University Medical Centre Göttingen, Germany.
Stefan M. Pfister
2German Cancer Research Center (DKFZ), Heidelberg, Germany.
4Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
56Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany.
Felix Sahm
54Department of Paediatric Haematology/Oncology Charité Universitätsmedizin, Berlin, Germany.
69Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Suzanne J. Baker
71Department of Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Angela Mastronuzzi
72Neuro-oncology Unit, Department of Onco-haematology, Cell and Gene Therapy, Bambino Gesù Children's Hospital-IRCCS, Rome, Italy.
Andrea Carai
73Oncological Neurosurgery Unit, Department of Neuroscience and Neurorehabilitation, Bambino Gesù Children's Hospital-IRCCS, Rome, Italy.
Maria Vinci
58Department of Onco-haematology, Cell and Gene Therapy, Bambino Gesù Children's Hospital-IRCCS, Rome, Italy.
David Capper
9Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Neuropathology, Berlin, Germany.
74German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Sergey Popov
1Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.
75Department of Pathology, University of Wales Hospital NHS Trust, Cardiff, United Kingdom.
David W. Ellison
6Department of Neuropathology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Thomas S. Jacques
5UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
David T.W. Jones
2German Cancer Research Center (DKFZ), Heidelberg, Germany.
4Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
Chris Jones
1Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.
DOI: 10.1158/2159-8290.CD-19-1030 Published July 2020
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Abstract
Infant high-grade gliomas appear clinically distinct from their counterparts in older children, indicating that histopathologic grading may not accurately reflect the biology of these tumors. We have collected 241 cases under 4 years of age, and carried out histologic review, methylation profiling, and custom panel, genome, or exome sequencing. After excluding tumors representing other established entities or subgroups, we identified 130 cases to be part of an “intrinsic” spectrum of disease specific to the infant population. These included those with targetable MAPK alterations, and a large proportion of remaining cases harboring gene fusions targeting ALK (n = 31), NTRK1/2/3 (n = 21), ROS1 (n = 9), and MET (n = 4) as their driving alterations, with evidence of efficacy of targeted agents in the clinic. These data strongly support the concept that infant gliomas require a change in diagnostic practice and management.
Significance: Infant high-grade gliomas in the cerebral hemispheres comprise novel subgroups, with a prevalence of ALK, NTRK1/2/3, ROS1, or MET gene fusions. Kinase fusion–positive tumors have better outcome and respond to targeted therapy clinically. Other subgroups have poor outcome, with fusion-negative cases possibly representing an epigenetically driven pluripotent stem cell phenotype.
See related video: https://vimeo.com/438254885
See related commentary by Szulzewsky and Cimino, p. 904.
This article is highlighted in the In This Issue feature, p. 890
Footnotes
Note: Supplementary data for this article are available at Cancer Discovery Online (http://cancerdiscovery.aacrjournals.org/).
Cancer Discov 2020;10:942–63
- Received September 4, 2019.
- Revision received March 3, 2020.
- Accepted March 20, 2020.
- Published first April 1, 2020.
- ©2020 American Association for Cancer Research.
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July 2020
Volume 10, Issue 7
Volume 10, Issue 7
Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes
Matthew Clarke, Alan Mackay, Britta Ismer, Jessica C. Pickles, Ruth G. Tatevossian, Scott Newman, Tejus A. Bale, Iris Stoler, Elisa Izquierdo, Sara Temelso, Diana M. Carvalho, Valeria Molinari, Anna Burford, Louise Howell, Alex Virasami, Amy R. Fairchild, Aimee Avery, Jane Chalker, Mark Kristiansen, Kelly Haupfear, James D. Dalton, Wilda Orisme, Ji Wen, Michael Hubank, Kathreena M. Kurian, Catherine Rowe, Mellissa Maybury, Stephen Crosier, Jeffrey Knipstein, Ulrich Schüller, Uwe Kordes, David E. Kram, Matija Snuderl, Leslie Bridges, Andrew J. Martin, Lawrence J. Doey, Safa Al-Sarraj, Christopher Chandler, Bassel Zebian, Claire Cairns, Rachael Natrajan, Jessica K.R. Boult, Simon P. Robinson, Martin Sill, Ira J. Dunkel, Stephen W. Gilheeney, Marc K. Rosenblum, Debbie Hughes, Paula Z. Proszek, Tobey J. Macdonald, Matthias Preusser, Christine Haberler, Irene Slavc, Roger Packer, Ho-Keung Ng, Shani Caspi, Mara Popović, Barbara Faganel Kotnik, Matthew D. Wood, Lissa Baird, Monika Ashok Davare, David A. Solomon, Thale Kristin Olsen, Petter Brandal, Michael Farrell, Jane B. Cryan, Michael Capra, Michael Karremann, Jens Schittenhelm, Martin U. Schuhmann, Martin Ebinger, Winand N.M. Dinjens, Kornelius Kerl, Simone Hettmer, Torsten Pietsch, Felipe Andreiuolo, Pablo Hernáiz Driever, Andrey Korshunov, Lotte Hiddingh, Barbara C. Worst, Dominik Sturm, Marc Zuckermann, Olaf Witt, Tabitha Bloom, Clare Mitchell, Evelina Miele, Giovanna Stefania Colafati, Francesca Diomedi-Camassei, Simon Bailey, Andrew S. Moore, Timothy E.G. Hassall, Stephen P. Lowis, Maria Tsoli, Mark J. Cowley, David S. Ziegler, Matthias A. Karajannis, Kristian Aquilina, Darren R. Hargrave, Fernando Carceller, Lynley V. Marshall, Andreas von Deimling, Christof M. Kramm, Stefan M. Pfister, Felix Sahm, Suzanne J. Baker, Angela Mastronuzzi, Andrea Carai, Maria Vinci, David Capper, Sergey Popov, David W. Ellison, Thomas S. Jacques, David T.W. Jones and Chris Jones
Cancer Discov July 1 2020 (10) (7) 942-963; DOI: 10.1158/2159-8290.CD-19-1030
Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes
Matthew Clarke, Alan Mackay, Britta Ismer, Jessica C. Pickles, Ruth G. Tatevossian, Scott Newman, Tejus A. Bale, Iris Stoler, Elisa Izquierdo, Sara Temelso, Diana M. Carvalho, Valeria Molinari, Anna Burford, Louise Howell, Alex Virasami, Amy R. Fairchild, Aimee Avery, Jane Chalker, Mark Kristiansen, Kelly Haupfear, James D. Dalton, Wilda Orisme, Ji Wen, Michael Hubank, Kathreena M. Kurian, Catherine Rowe, Mellissa Maybury, Stephen Crosier, Jeffrey Knipstein, Ulrich Schüller, Uwe Kordes, David E. Kram, Matija Snuderl, Leslie Bridges, Andrew J. Martin, Lawrence J. Doey, Safa Al-Sarraj, Christopher Chandler, Bassel Zebian, Claire Cairns, Rachael Natrajan, Jessica K.R. Boult, Simon P. Robinson, Martin Sill, Ira J. Dunkel, Stephen W. Gilheeney, Marc K. Rosenblum, Debbie Hughes, Paula Z. Proszek, Tobey J. Macdonald, Matthias Preusser, Christine Haberler, Irene Slavc, Roger Packer, Ho-Keung Ng, Shani Caspi, Mara Popović, Barbara Faganel Kotnik, Matthew D. Wood, Lissa Baird, Monika Ashok Davare, David A. Solomon, Thale Kristin Olsen, Petter Brandal, Michael Farrell, Jane B. Cryan, Michael Capra, Michael Karremann, Jens Schittenhelm, Martin U. Schuhmann, Martin Ebinger, Winand N.M. Dinjens, Kornelius Kerl, Simone Hettmer, Torsten Pietsch, Felipe Andreiuolo, Pablo Hernáiz Driever, Andrey Korshunov, Lotte Hiddingh, Barbara C. Worst, Dominik Sturm, Marc Zuckermann, Olaf Witt, Tabitha Bloom, Clare Mitchell, Evelina Miele, Giovanna Stefania Colafati, Francesca Diomedi-Camassei, Simon Bailey, Andrew S. Moore, Timothy E.G. Hassall, Stephen P. Lowis, Maria Tsoli, Mark J. Cowley, David S. Ziegler, Matthias A. Karajannis, Kristian Aquilina, Darren R. Hargrave, Fernando Carceller, Lynley V. Marshall, Andreas von Deimling, Christof M. Kramm, Stefan M. Pfister, Felix Sahm, Suzanne J. Baker, Angela Mastronuzzi, Andrea Carai, Maria Vinci, David Capper, Sergey Popov, David W. Ellison, Thomas S. Jacques, David T.W. Jones and Chris Jones
Cancer Discov July 1 2020 (10) (7) 942-963; DOI: 10.1158/2159-8290.CD-19-1030
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