Gain-of-Function Genetic Alterations of G9a Drive Oncogenesis

Shinichiro Kato; Qing Yu Weng; Megan L. Insco; Kevin Y. Chen; Sathya Muralidhar; Joanna Pozniak; Joey Mark S. Diaz; Yotam Drier; Nhu Nguyen; Jennifer A. Lo; Ellen van Rooijen; Lajos V. Kemeny; Yao Zhan; Yang Feng; Whitney Silkworth; C. Thomas Powell; Brian B. Liau; Yan Xiong; Jian Jin; Julia Newton-Bishop; Leonard I. Zon; Bradley E. Bernstein; David E. Fisher

doi:10.1158/2159-8290.CD-19-0532

Research Articles

Gain-of-Function Genetic Alterations of G9a Drive Oncogenesis

Shinichiro Kato, Qing Yu Weng, Megan L. Insco, Kevin Y. Chen, Sathya Muralidhar, Joanna Pozniak, Joey Mark S. Diaz, Yotam Drier, Nhu Nguyen, Jennifer A. Lo, Ellen van Rooijen, Lajos V. Kemeny, Yao Zhan, Yang Feng, Whitney Silkworth, C. Thomas Powell, Brian B. Liau, Yan Xiong, Jian Jin, Julia Newton-Bishop, Leonard I. Zon, Bradley E. Bernstein and David E. Fisher

Shinichiro Kato

1Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts.

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Qing Yu Weng

1Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts.

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ORCID record for Qing Yu Weng

Megan L. Insco

2Howard Hughes Medical Institute, Chevy Chase, Maryland.

3Stem Cell Program and Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

4Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Cambridge, Massachusetts.

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Kevin Y. Chen

2Howard Hughes Medical Institute, Chevy Chase, Maryland.

3Stem Cell Program and Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

4Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Cambridge, Massachusetts.

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Sathya Muralidhar

5Institute of Medical Research at St James's, University of Leeds, Leeds, United Kingdom.

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Joanna Pozniak

5Institute of Medical Research at St James's, University of Leeds, Leeds, United Kingdom.

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Joey Mark S. Diaz

5Institute of Medical Research at St James's, University of Leeds, Leeds, United Kingdom.

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Yotam Drier

6Center for Cancer Research, Massachusetts General Hospital, Boston, Massachusetts.

7Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

8Broad Institute of MIT and Harvard, Cambridge, Massachusetts.

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Nhu Nguyen

1Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts.

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Jennifer A. Lo

1Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts.

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Ellen van Rooijen

2Howard Hughes Medical Institute, Chevy Chase, Maryland.

3Stem Cell Program and Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

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Lajos V. Kemeny

1Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts.

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Yao Zhan

1Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts.

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Yang Feng

1Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts.

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Whitney Silkworth

1Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts.

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ORCID record for Whitney Silkworth

C. Thomas Powell

1Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts.

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Brian B. Liau

9Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts.

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Yan Xiong

10Mount Sinai Center for Therapeutics Discovery, Department of Pharmaceutical Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.

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Jian Jin

10Mount Sinai Center for Therapeutics Discovery, Department of Pharmaceutical Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.

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Julia Newton-Bishop

5Institute of Medical Research at St James's, University of Leeds, Leeds, United Kingdom.

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Leonard I. Zon

2Howard Hughes Medical Institute, Chevy Chase, Maryland.

3Stem Cell Program and Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

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Bradley E. Bernstein

6Center for Cancer Research, Massachusetts General Hospital, Boston, Massachusetts.

7Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

8Broad Institute of MIT and Harvard, Cambridge, Massachusetts.

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David E. Fisher

1Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts.

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For correspondence: dfisher3@mgh.harvard.edu

DOI: 10.1158/2159-8290.CD-19-0532 Published July 2020

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July 2020
Volume 10, Issue 7

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Gain-of-Function Genetic Alterations of G9a Drive Oncogenesis