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The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer

Hui Liu, Marcia N. Paddock, Haibin Wang, Charles J. Murphy, Renee C. Geck, Adrija J. Navarro, Gerburg M. Wulf, Olivier Elemento, Volker Haucke, Lewis C. Cantley and Alex Toker
Hui Liu
1Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
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  • For correspondence: atoker@bidmc.harvard.edu LCantley@med.cornell.edu hliu5@bidmc.harvard.edu
Marcia N. Paddock
2Meyer Cancer Center, Weill Cornell Medicine, New York, New York.
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Haibin Wang
3Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.
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Charles J. Murphy
2Meyer Cancer Center, Weill Cornell Medicine, New York, New York.
4Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York.
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Renee C. Geck
1Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
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  • ORCID record for Renee C. Geck
Adrija J. Navarro
1Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
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Gerburg M. Wulf
5Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
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Olivier Elemento
4Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York.
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Volker Haucke
3Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.
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  • ORCID record for Volker Haucke
Lewis C. Cantley
2Meyer Cancer Center, Weill Cornell Medicine, New York, New York.
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  • ORCID record for Lewis C. Cantley
  • For correspondence: atoker@bidmc.harvard.edu LCantley@med.cornell.edu hliu5@bidmc.harvard.edu
Alex Toker
1Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
6Ludwig Center at Harvard, Boston, Massachusetts.
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  • For correspondence: atoker@bidmc.harvard.edu LCantley@med.cornell.edu hliu5@bidmc.harvard.edu
DOI: 10.1158/2159-8290.CD-19-1262 Published August 2020
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Article Information

Volume 10, Issue 8, pp. 1226-1239

DOI 
https://doi.org/10.1158/2159-8290.CD-19-1262
PubMed 
32513774

Published By 
American Association for Cancer Research
Print ISSN 
2159-8274
Online ISSN 
2159-8290
History 
  • Received October 23, 2019
  • Revision received April 22, 2020
  • Accepted June 2, 2020
  • Published first June 8, 2020.

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  • Previous version (June 8, 2020 - 05:50).
  • Previous version (July 14, 2020 - 06:10).
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©2020 American Association for Cancer Research.

Author Information

  1. Hui Liu1,*,
  2. Marcia N. Paddock2,
  3. Haibin Wang3,
  4. Charles J. Murphy2,4,
  5. Renee C. Geck1,
  6. Adrija J. Navarro1,
  7. Gerburg M. Wulf5,
  8. Olivier Elemento4,
  9. Volker Haucke3,
  10. Lewis C. Cantley2,* and
  11. Alex Toker1,6,*
  1. 1Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
  2. 2Meyer Cancer Center, Weill Cornell Medicine, New York, New York.
  3. 3Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.
  4. 4Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York.
  5. 5Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
  6. 6Ludwig Center at Harvard, Boston, Massachusetts.
  1. ↵*Corresponding Authors:
    Alex Toker, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, EC/CLS-633A, Boston, MA 02215. Phone: 617-735-2482; Fax: 617-735-2480; E-mail: atoker{at}bidmc.harvard.edu; Lewis C. Cantley, The Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, 413 East 69th Street, 13th Floor, Box 50, New York, NY 10021. Phone: 646-962-6132; Fax: 646-962-0575; E-mail: LCantley{at}med.cornell.edu; and Hui Liu, Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, CLS-628, Boston, MA 02215. Phone: 617-275-3922; E-mail: hliu5{at}bidmc.harvard.edu
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Cancer Discovery: 10 (8)
August 2020
Volume 10, Issue 8
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The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer
Hui Liu, Marcia N. Paddock, Haibin Wang, Charles J. Murphy, Renee C. Geck, Adrija J. Navarro, Gerburg M. Wulf, Olivier Elemento, Volker Haucke, Lewis C. Cantley and Alex Toker
Cancer Discov August 1 2020 (10) (8) 1226-1239; DOI: 10.1158/2159-8290.CD-19-1262

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The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer
Hui Liu, Marcia N. Paddock, Haibin Wang, Charles J. Murphy, Renee C. Geck, Adrija J. Navarro, Gerburg M. Wulf, Olivier Elemento, Volker Haucke, Lewis C. Cantley and Alex Toker
Cancer Discov August 1 2020 (10) (8) 1226-1239; DOI: 10.1158/2159-8290.CD-19-1262
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