Table of Contents

Research Articles

• Research Articles

  Inactivation of Fbxw7 Impairs dsRNA Sensing and Confers Resistance to PD-1 Blockade

  Cécile Gstalder, David Liu, Diana Miao, Bart Lutterbach, Alexander L. DeVine, Chenyu Lin, Megha Shettigar, Priya Pancholi, Elizabeth I. Buchbinder, Scott L. Carter, Michael P. Manos, Vanesa Rojas-Rudilla, Ryan Brennick, Evisa Gjini, Pei-Hsuan Chen, Ana Lako, Scott Rodig, Charles H. Yoon, Gordon J. Freeman, David A. Barbie, F. Stephen Hodi, Wayne Miles, Eliezer M. Van Allen and Rizwan Haq

  Cancer Discov September 1 2020 10 (9) 1296-1311; DOI:10.1158/2159-8290.CD-19-1416

  
  

  Loss of function of the tumor-suppressor gene Fbxw7 conferred resistance to PD-1 blockade by decreasing expression of dsRNA sensors, leading to an altered tumor immune microenvironment.

• Research Articles

  Epigenetic Switch–Induced Viral Mimicry Evasion in Chemotherapy-Resistant Breast Cancer

  Geneviève Deblois, Seyed Ali Madani Tonekaboni, Giacomo Grillo, Constanza Martinez, Yunchi Ingrid Kao, Felicia Tai, Ilias Ettayebi, Anne-Marie Fortier, Paul Savage, Alexandra N. Fedor, Xiaojing Liu, Paul Guilhamon, Evelyne Lima-Fernandes, Alex Murison, Hellen Kuasne, Wail Ba-alawi, David W. Cescon, Cheryl H. Arrowsmith, Daniel D. De Carvalho, Benjamin Haibe-Kains, Jason W. Locasale, Morag Park and Mathieu Lupien

  Cancer Discov September 1 2020 10 (9) 1312-1329; DOI:10.1158/2159-8290.CD-19-1493

  
  

  Taxane-resistant triple-negative breast cancer cells had altered methionine metabolism, leading to epigenetic changes at transposable elements and creating a therapeutic vulnerability to EZH2 inhibitors.

• Research Articles | AuthorChoice

  Single-Cell Analysis Reveals Fibroblast Clusters Linked to Immunotherapy Resistance in Cancer

  Yann Kieffer, Hocine R. Hocine, Géraldine Gentric, Floriane Pelon, Charles Bernard, Brigitte Bourachot, Sonia Lameiras, Luca Albergante, Claire Bonneau, Alice Guyard, Karin Tarte, Andrei Zinovyev, Sylvain Baulande, Gerard Zalcman, Anne Vincent-Salomon and Fatima Mechta-Grigoriou

  Cancer Discov September 1 2020 10 (9) 1330-1351; DOI:10.1158/2159-8290.CD-19-1384

  
  

  An immunosuppressive subtype of cancer-associated fibroblast was heterogeneous, with only certain subsets modulating immune-cell infiltration in the tumor microenvironment and immunotherapy response.

• Research Articles

  Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition

  Bryan Ngo, Eugenie Kim, Victoria Osorio-Vasquez, Sophia Doll, Sophia Bustraan, Roger J. Liang, Alba Luengo, Shawn M. Davidson, Ahmed Ali, Gino B. Ferraro, Grant M. Fischer, Roozbeh Eskandari, Diane S. Kang, Jing Ni, Ariana Plasger, Vinagolu K. Rajasekhar, Edward R. Kastenhuber, Sarah Bacha, Roshan K. Sriram, Benjamin D. Stein, Samuel F. Bakhoum, Matija Snuderl, Paolo Cotzia, John H. Healey, Nello Mainolfi, Vipin Suri, Adam Friedman, Mark Manfredi, David M. Sabatini, Drew R. Jones, Min Yu, Jean J. Zhao, Rakesh K. Jain, Kayvan R. Keshari, Michael A. Davies, Matthew G. Vander Heiden, Eva Hernando, Matthias Mann, Lewis C. Cantley and Michael E. Pacold

  Cancer Discov September 1 2020 10 (9) 1352-1373; DOI:10.1158/2159-8290.CD-19-1228

  
  

  The serine-synthesis enzyme PHGDH was necessary and sufficient for metastasis to the brain, where amino acid availability is limited, and PHGDH inhibition suppressed brain metastasis.

• Research Articles

  Chromatin Regulator CHD1 Remodels the Immunosuppressive Tumor Microenvironment in PTEN-Deficient Prostate Cancer

  Di Zhao, Li Cai, Xin Lu, Xin Liang, Jiexi Li, Peiwen Chen, Michael Ittmann, Xiaoying Shang, Shan Jiang, Haoyan Li, Chenling Meng, Ivonne Flores, Jian H. Song, James W. Horner, Zhengdao Lan, Chang-Jiun Wu, Jun Li, Qing Chang, Ko-Chien Chen, Guocan Wang, Pingna Deng, Denise J. Spring, Y. Alan Wang and Ronald A. DePinho

  Cancer Discov September 1 2020 10 (9) 1374-1387; DOI:10.1158/2159-8290.CD-19-1352

  
  

  The tumor suppressor CHD1 increased IL6 expression to recruit myeloid-derived suppressor cells to Pten-null prostate tumors, and CHD1 depletion or IL6 inhibition enhanced the efficacy of immune checkpoint blockade.

• Research Articles

  Posttranslational Regulation of the Exon Skipping Machinery Controls Aberrant Splicing in Leukemia

  Yalu Zhou, Cuijuan Han, Eric Wang, Adam H. Lorch, Valentina Serafin, Byoung-Kyu Cho, Blanca T. Gutierrez Diaz, Julien Calvo, Celestia Fang, Alireza Khodadadi-Jamayran, Tommaso Tabaglio, Christian Marier, Anna Kuchmiy, Limin Sun, George Yacu, Szymon K. Filip, Qi Jin, Yoh-Hei Takahashi, David R. Amici, Emily J. Rendleman, Radhika Rawat, Silvia Bresolin, Maddalena Paganin, Cheng Zhang, Hu Li, Irawati Kandela, Yuliya Politanska, Hiam Abdala-Valencia, Marc L. Mendillo, Ping Zhu, Bruno Palhais, Pieter Van Vlierberghe, Tom Taghon, Iannis Aifantis, Young Ah Goo, Ernesto Guccione, Adriana Heguy, Aristotelis Tsirigos, Keng Boon Wee, Rama K. Mishra, Francoise Pflumio, Benedetta Accordi, Giuseppe Basso and Panagiotis Ntziachristos

  Cancer Discov September 1 2020 10 (9) 1388-1409; DOI:10.1158/2159-8290.CD-19-1436

  
  

  Increased exon skipping, particularly affecting proteasome-related transcripts, was mediated by elevated serine/arginine-rich splicing factor 6 (SRSF6) levels in T-cell acute lymphoblastic leukemia.

• Research Articles

  RBMS1 Suppresses Colon Cancer Metastasis through Targeted Stabilization of Its mRNA Regulon

  Johnny Yu, Albertas Navickas, Hosseinali Asgharian, Bruce Culbertson, Lisa Fish, Kristle Garcia, John Paolo Olegario, Maria Dermit, Martin Dodel, Benjamin Hänisch, Yikai Luo, Ethan M. Weinberg, Rodrigo Dienstmann, Robert S. Warren, Faraz K. Mardakheh and Hani Goodarzi

  Cancer Discov September 1 2020 10 (9) 1410-1423; DOI:10.1158/2159-8290.CD-19-1375

  
  

  A new analytic method identified RBMS1, which acted as a posttranscriptional regulator that bound and stabilized the 3′ untranslated region of target mRNAs, as a suppressor of metastasis in colorectal cancer.