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Cancer Discovery
Cancer Discovery
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Table of Contents

In This Issue

  • In This Issue
    In This Issue
    Cancer Discov September 1 2020 10 (9) 1241-1244; DOI:10.1158/2159-8290.CD-ITI10-9

In the Spotlight

  • In the Spotlight
    The Aged Microenvironment of Melanoma Feeds Escape from Targeted Therapy
    Emily D. Montal and Richard M. White
    Cancer Discov September 1 2020 10 (9) 1255-1257; DOI:10.1158/2159-8290.CD-20-0949

  • In the Spotlight
    Epigenetic Awakening of Viral Mimicry in Cancer
    Maxime Janin and Manel Esteller
    Cancer Discov September 1 2020 10 (9) 1258-1260; DOI:10.1158/2159-8290.CD-20-0947

  • In the Spotlight
    Loss of RNA-Binding Protein RBMS1 Promotes a Metastatic Transcriptional Program in Colorectal Cancer
    Hannah Carter
    Cancer Discov September 1 2020 10 (9) 1261-1262; DOI:10.1158/2159-8290.CD-20-0993

Science in Society

  • Science in Society | Free Article
    Cancer Research: The Lessons to Learn from COVID-19
    Chris Bailey, James R.M. Black and Charles Swanton
    Cancer Discov September 1 2020 10 (9) 1263-1266; DOI:10.1158/2159-8290.CD-20-0823

Review

  • Review
    Toward a New Molecular Taxonomy of Diffuse Large B-cell Lymphoma
    Daisuke Ennishi, Eric D. Hsi, Christian Steidl and David W. Scott
    Cancer Discov September 1 2020 10 (9) 1267-1281; DOI:10.1158/2159-8290.CD-20-0174

Research Brief

  • Research Brief
    Changes in Aged Fibroblast Lipid Metabolism Induce Age-Dependent Melanoma Cell Resistance to Targeted Therapy via the Fatty Acid Transporter FATP2
    Gretchen M. Alicea, Vito W. Rebecca, Aaron R. Goldman, Mitchell E. Fane, Stephen M. Douglass, Reeti Behera, Marie R. Webster, Curtis H. Kugel III, Brett L. Ecker, M. Cecilia Caino, Andrew V. Kossenkov, Hsin-Yao Tang, Dennie T. Frederick, Keith T. Flaherty, Xiaowei Xu, Qin Liu, Dmitry I. Gabrilovich, Meenhard Herlyn, Ian A. Blair, Zachary T. Schug, David W. Speicher and Ashani T. Weeraratna
    Cancer Discov September 1 2020 10 (9) 1282-1295; DOI:10.1158/2159-8290.CD-20-0329

    Aged dermal fibroblasts secreted altered levels of several lipids, which entered melanoma cells via the fatty acid transporter FATP2, the inhibition of which synergized with targeted therapy in aged mice.

Research Articles

  • Research Articles
    Inactivation of Fbxw7 Impairs dsRNA Sensing and Confers Resistance to PD-1 Blockade
    Cécile Gstalder, David Liu, Diana Miao, Bart Lutterbach, Alexander L. DeVine, Chenyu Lin, Megha Shettigar, Priya Pancholi, Elizabeth I. Buchbinder, Scott L. Carter, Michael P. Manos, Vanesa Rojas-Rudilla, Ryan Brennick, Evisa Gjini, Pei-Hsuan Chen, Ana Lako, Scott Rodig, Charles H. Yoon, Gordon J. Freeman, David A. Barbie, F. Stephen Hodi, Wayne Miles, Eliezer M. Van Allen and Rizwan Haq
    Cancer Discov September 1 2020 10 (9) 1296-1311; DOI:10.1158/2159-8290.CD-19-1416

    Loss of function of the tumor-suppressor gene Fbxw7 conferred resistance to PD-1 blockade by decreasing expression of dsRNA sensors, leading to an altered tumor immune microenvironment.

  • Research Articles
    Epigenetic Switch–Induced Viral Mimicry Evasion in Chemotherapy-Resistant Breast Cancer
    Geneviève Deblois, Seyed Ali Madani Tonekaboni, Giacomo Grillo, Constanza Martinez, Yunchi Ingrid Kao, Felicia Tai, Ilias Ettayebi, Anne-Marie Fortier, Paul Savage, Alexandra N. Fedor, Xiaojing Liu, Paul Guilhamon, Evelyne Lima-Fernandes, Alex Murison, Hellen Kuasne, Wail Ba-alawi, David W. Cescon, Cheryl H. Arrowsmith, Daniel D. De Carvalho, Benjamin Haibe-Kains, Jason W. Locasale, Morag Park and Mathieu Lupien
    Cancer Discov September 1 2020 10 (9) 1312-1329; DOI:10.1158/2159-8290.CD-19-1493

    Taxane-resistant triple-negative breast cancer cells had altered methionine metabolism, leading to epigenetic changes at transposable elements and creating a therapeutic vulnerability to EZH2 inhibitors.

  • Research Articles | AuthorChoice
    Single-Cell Analysis Reveals Fibroblast Clusters Linked to Immunotherapy Resistance in Cancer
    Yann Kieffer, Hocine R. Hocine, Géraldine Gentric, Floriane Pelon, Charles Bernard, Brigitte Bourachot, Sonia Lameiras, Luca Albergante, Claire Bonneau, Alice Guyard, Karin Tarte, Andrei Zinovyev, Sylvain Baulande, Gerard Zalcman, Anne Vincent-Salomon and Fatima Mechta-Grigoriou
    Cancer Discov September 1 2020 10 (9) 1330-1351; DOI:10.1158/2159-8290.CD-19-1384

    An immunosuppressive subtype of cancer-associated fibroblast was heterogeneous, with only certain subsets modulating immune-cell infiltration in the tumor microenvironment and immunotherapy response.

  • Research Articles
    Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition
    Bryan Ngo, Eugenie Kim, Victoria Osorio-Vasquez, Sophia Doll, Sophia Bustraan, Roger J. Liang, Alba Luengo, Shawn M. Davidson, Ahmed Ali, Gino B. Ferraro, Grant M. Fischer, Roozbeh Eskandari, Diane S. Kang, Jing Ni, Ariana Plasger, Vinagolu K. Rajasekhar, Edward R. Kastenhuber, Sarah Bacha, Roshan K. Sriram, Benjamin D. Stein, Samuel F. Bakhoum, Matija Snuderl, Paolo Cotzia, John H. Healey, Nello Mainolfi, Vipin Suri, Adam Friedman, Mark Manfredi, David M. Sabatini, Drew R. Jones, Min Yu, Jean J. Zhao, Rakesh K. Jain, Kayvan R. Keshari, Michael A. Davies, Matthew G. Vander Heiden, Eva Hernando, Matthias Mann, Lewis C. Cantley and Michael E. Pacold
    Cancer Discov September 1 2020 10 (9) 1352-1373; DOI:10.1158/2159-8290.CD-19-1228

    The serine-synthesis enzyme PHGDH was necessary and sufficient for metastasis to the brain, where amino acid availability is limited, and PHGDH inhibition suppressed brain metastasis.

  • Research Articles
    Chromatin Regulator CHD1 Remodels the Immunosuppressive Tumor Microenvironment in PTEN-Deficient Prostate Cancer
    Di Zhao, Li Cai, Xin Lu, Xin Liang, Jiexi Li, Peiwen Chen, Michael Ittmann, Xiaoying Shang, Shan Jiang, Haoyan Li, Chenling Meng, Ivonne Flores, Jian H. Song, James W. Horner, Zhengdao Lan, Chang-Jiun Wu, Jun Li, Qing Chang, Ko-Chien Chen, Guocan Wang, Pingna Deng, Denise J. Spring, Y. Alan Wang and Ronald A. DePinho
    Cancer Discov September 1 2020 10 (9) 1374-1387; DOI:10.1158/2159-8290.CD-19-1352

    The tumor suppressor CHD1 increased IL6 expression to recruit myeloid-derived suppressor cells to Pten-null prostate tumors, and CHD1 depletion or IL6 inhibition enhanced the efficacy of immune checkpoint blockade.

  • Research Articles
    Posttranslational Regulation of the Exon Skipping Machinery Controls Aberrant Splicing in Leukemia
    Yalu Zhou, Cuijuan Han, Eric Wang, Adam H. Lorch, Valentina Serafin, Byoung-Kyu Cho, Blanca T. Gutierrez Diaz, Julien Calvo, Celestia Fang, Alireza Khodadadi-Jamayran, Tommaso Tabaglio, Christian Marier, Anna Kuchmiy, Limin Sun, George Yacu, Szymon K. Filip, Qi Jin, Yoh-Hei Takahashi, David R. Amici, Emily J. Rendleman, Radhika Rawat, Silvia Bresolin, Maddalena Paganin, Cheng Zhang, Hu Li, Irawati Kandela, Yuliya Politanska, Hiam Abdala-Valencia, Marc L. Mendillo, Ping Zhu, Bruno Palhais, Pieter Van Vlierberghe, Tom Taghon, Iannis Aifantis, Young Ah Goo, Ernesto Guccione, Adriana Heguy, Aristotelis Tsirigos, Keng Boon Wee, Rama K. Mishra, Francoise Pflumio, Benedetta Accordi, Giuseppe Basso and Panagiotis Ntziachristos
    Cancer Discov September 1 2020 10 (9) 1388-1409; DOI:10.1158/2159-8290.CD-19-1436

    Increased exon skipping, particularly affecting proteasome-related transcripts, was mediated by elevated serine/arginine-rich splicing factor 6 (SRSF6) levels in T-cell acute lymphoblastic leukemia.

  • Research Articles
    RBMS1 Suppresses Colon Cancer Metastasis through Targeted Stabilization of Its mRNA Regulon
    Johnny Yu, Albertas Navickas, Hosseinali Asgharian, Bruce Culbertson, Lisa Fish, Kristle Garcia, John Paolo Olegario, Maria Dermit, Martin Dodel, Benjamin Hänisch, Yikai Luo, Ethan M. Weinberg, Rodrigo Dienstmann, Robert S. Warren, Faraz K. Mardakheh and Hani Goodarzi
    Cancer Discov September 1 2020 10 (9) 1410-1423; DOI:10.1158/2159-8290.CD-19-1375

    A new analytic method identified RBMS1, which acted as a posttranscriptional regulator that bound and stabilized the 3′ untranslated region of target mRNAs, as a suppressor of metastasis in colorectal cancer.

News in Brief

  • News in Brief
    People
    Cancer Discov September 1 2020 10 (9) 1246-1246; DOI:10.1158/2159-8290.CD-NB2020-066

  • News in Brief
    RET Inhibitor Prompts Roche–Blueprint Alliance
    Cancer Discov September 1 2020 10 (9) 1246-1246; DOI:10.1158/2159-8290.CD-NB2020-070

  • News in Brief
    Blood Test Catches Cancers That Shed Little DNA
    Cancer Discov September 1 2020 10 (9) 1246-1247; DOI:10.1158/2159-8290.CD-NB2020-068

  • News in Brief
    Viral Analysis: Early Detection of HCC
    Cancer Discov September 1 2020 10 (9) 1247-1248; DOI:10.1158/2159-8290.CD-NB2020-065

  • News in Brief | Free Article
    COVID-19 Challenges Status Quo for Cancer Care
    Cancer Discov September 1 2020 10 (9) 1248-1248; DOI:10.1158/2159-8290.CD-NB2020-069

  • News in Brief
    Vor Nets $110m to Make Anti-CD33 Drugs Safer
    Cancer Discov September 1 2020 10 (9) 1248-1249; DOI:10.1158/2159-8290.CD-NB2020-073

  • News in Brief
    Noted
    Cancer Discov September 1 2020 10 (9) 1249-1249; DOI:10.1158/2159-8290.CD-NB2020-067

  • News in Brief
    USPSTF Proposes Expanded Lung Cancer Screening
    Cancer Discov September 1 2020 10 (9) OF1-OF1; DOI:10.1158/2159-8290.CD-NB2020-072

Research Watch

  • Clinical Trials

    • Research Watch
      CD30-Targeted CAR T Cells Show Promise in Pretreated Hodgkin Lymphoma
      Cancer Discov September 1 2020 10 (9) 1253-1253; DOI:10.1158/2159-8290.CD-RW2020-111

    • Research Watch
      Berzosertib Is Safe, with Signs of Efficacy against Advanced Solid Tumors
      Cancer Discov September 1 2020 10 (9) 1250-1250; DOI:10.1158/2159-8290.CD-RW2020-103

    • Research Watch
      Early Data Supports Avapritinib for Gastrointestinal Stromal Tumors
      Cancer Discov September 1 2020 10 (9) 1251-1251; DOI:10.1158/2159-8290.CD-RW2020-104

    • Research Watch
      The CD70 Antibody Cusatuzumab Shows Promise in Acute Myeloid Leukemia
      Cancer Discov September 1 2020 10 (9) 1251-1251; DOI:10.1158/2159-8290.CD-RW2020-106

  • Drug Development

    • Research Watch
      A Therapeutic GFRAL Antibody Blocks Cancer-Linked Cachexia in Mice
      Cancer Discov September 1 2020 10 (9) 1252-1252; DOI:10.1158/2159-8290.CD-RW2020-109

  • Immunotherapy

    • Research Watch
      Immune-Checkpoint Blockade Induces Colitis via Immune-Cell Alterations
      Cancer Discov September 1 2020 10 (9) 1254-1254; DOI:10.1158/2159-8290.CD-RW2020-105

  • Leukemia

    • Research Watch
      The Oncogenes STAT5 and ERK Have Opposing Roles in Leukemogenesis
      Cancer Discov September 1 2020 10 (9) 1253-1253; DOI:10.1158/2159-8290.CD-RW2020-112

  • Lung Cancer

    • Research Watch
      Lung Cancer Cells Become Plastic and Lose Identity as Tumors Progress
      Cancer Discov September 1 2020 10 (9) OF2-OF2; DOI:10.1158/2159-8290.CD-RW2020-113

  • Lymphoma

    • Research Watch
      TBL1XR1 Mutations Bias toward Memory B-cell Fate to Promote Lymphoma
      Cancer Discov September 1 2020 10 (9) 1252-1252; DOI:10.1158/2159-8290.CD-RW2020-108

  • Metabolism

    • Research Watch
      Mitochondrial Oxidation of Ubiquinol Is Required for Tumorigenesis
      Cancer Discov September 1 2020 10 (9) 1250-1250; DOI:10.1158/2159-8290.CD-RW2020-107

  • Metastatsis

    • Research Watch
      Cancer Cells Survive Iron-Poor Cerebrospinal Fluid Using Lipocalin-2
      Cancer Discov September 1 2020 10 (9) 1254-1254; DOI:10.1158/2159-8290.CD-RW2020-110

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Cancer Discovery: 10 (9)
September 2020
Volume 10, Issue 9
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