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Abstract
Summary: Alicea and colleagues demonstrate that aged fibroblasts secrete lipids into the tumor microenvironment, allowing for nutrient exchange with melanoma cells. This supportive function of fibroblasts results in increased resistance to BRAF/MEKi therapy in the context of an aged microenvironment, providing crucial mechanistic insight into age-related drug resistance.
See related article by Alicea et al., p. 1282.
Footnotes
Cancer Discov 2020;10:1255–7
- ©2020 American Association for Cancer Research.
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September 2020
Volume 10, Issue 9
Volume 10, Issue 9
The Aged Microenvironment of Melanoma Feeds Escape from Targeted Therapy
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- Article
- Abstract
- Introduction
- Age as a Determining Factor of The TME in The Skin
- FATP as a Mediator of Increased Lipid Uptake and Metabolism
- Lipids as Mediators of Resistance
- Combinatory Treatment Strategies to Combat Resistance in Aged Mice
- Conclusion
- Disclosure of Potential Conflicts of Interest
- Footnotes
- References
- Figures & Data
- Info & Metrics
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