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Abstract
Summary: In this issue, Deblois and colleagues show how taxane-resistant triple-negative breast cancer cells evade viral mimicry response as a result of metabolic alteration, DNA hypomethylation, and relocation of histone H3K27 trimethylation (H3K27me3). This adaptation confers a therapeutic vulnerability to the inhibition of the H3K27me3 methyltransferase EZH2 in resistant cells, leading to tumor growth inhibition by viral mimicry reactivation.
See related article by Deblois et al., p. 1312.
Footnotes
Cancer Discov 2020;10:1258–60
- ©2020 American Association for Cancer Research.
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September 2020
Volume 10, Issue 9
Volume 10, Issue 9
Epigenetic Awakening of Viral Mimicry in Cancer
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