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Cancer Discovery
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Epigenetic Awakening of Viral Mimicry in Cancer

Maxime Janin and Manel Esteller
Maxime Janin
1Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain.
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  • ORCID record for Maxime Janin
Manel Esteller
1Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain.
2Centro de Investigacion Biomedica en Red Cancer (CIBERONC), Madrid, Spain.
3Physiological Sciences Department, School of Medicine and Health Sciences, University of Barcelona (UB), Barcelona, Catalonia, Spain.
4Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain.
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DOI: 10.1158/2159-8290.CD-20-0947 Published September 2020
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Abstract

Summary: In this issue, Deblois and colleagues show how taxane-resistant triple-negative breast cancer cells evade viral mimicry response as a result of metabolic alteration, DNA hypomethylation, and relocation of histone H3K27 trimethylation (H3K27me3). This adaptation confers a therapeutic vulnerability to the inhibition of the H3K27me3 methyltransferase EZH2 in resistant cells, leading to tumor growth inhibition by viral mimicry reactivation.

See related article by Deblois et al., p. 1312.

Footnotes

  • Cancer Discov 2020;10:1258–60

  • ©2020 American Association for Cancer Research.
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Cancer Discovery: 10 (9)
September 2020
Volume 10, Issue 9
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Epigenetic Awakening of Viral Mimicry in Cancer
Maxime Janin and Manel Esteller
Cancer Discov September 1 2020 (10) (9) 1258-1260; DOI: 10.1158/2159-8290.CD-20-0947

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Epigenetic Awakening of Viral Mimicry in Cancer
Maxime Janin and Manel Esteller
Cancer Discov September 1 2020 (10) (9) 1258-1260; DOI: 10.1158/2159-8290.CD-20-0947
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Cancer Discovery
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