An Epigenetic Mechanism Underlying Chromosome 17p Deletion–Driven Tumorigenesis

Mei Chen; Xuelan Chen; Shujun Li; Xiangyu Pan; Yanqiu Gong; Jianan Zheng; Jing Xu; Chengjian Zhao; Qi Zhang; Shan Zhang; Lu Qi; Zhongwang Wang; Kaidou Shi; Bi-Sen Ding; Zhihong Xue; Lu Chen; Shengyong Yang; Yuan Wang; Ting Niu; Lunzhi Dai; Scott W. Lowe; Chong Chen; Yu Liu

doi:10.1158/2159-8290.CD-20-0336

Research Articles

An Epigenetic Mechanism Underlying Chromosome 17p Deletion–Driven Tumorigenesis

Mei Chen, Xuelan Chen, Shujun Li, Xiangyu Pan, Yanqiu Gong, Jianan Zheng, Jing Xu, Chengjian Zhao, Qi Zhang, Shan Zhang, Lu Qi, Zhongwang Wang, Kaidou Shi, Bi-Sen Ding, Zhihong Xue, Lu Chen, Shengyong Yang, Yuan Wang, Ting Niu, Lunzhi Dai, Scott W. Lowe, Chong Chen and Yu Liu

Mei Chen

1Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

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Xuelan Chen

1Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

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Shujun Li

1Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

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Xiangyu Pan

1Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

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Yanqiu Gong

2Department of General Practice and National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

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Jianan Zheng

1Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

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Jing Xu

1Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

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Chengjian Zhao

1Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

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Qi Zhang

1Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

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Shan Zhang

1Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

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Lu Qi

1Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

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Zhongwang Wang

1Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

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Kaidou Shi

1Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

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Bi-Sen Ding

3Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.

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Zhihong Xue

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Lu Chen

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Shengyong Yang

1Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

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Yuan Wang

1Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

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Ting Niu

1Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

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Lunzhi Dai

2Department of General Practice and National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

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Scott W. Lowe

4Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York.

5Howard Hughes Medical Institute, New York, New York.

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Chong Chen

1Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

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For correspondence: chongchen@scu.edu.cn yuliuscu@scu.edu.cn

Yu Liu

1Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

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For correspondence: chongchen@scu.edu.cn yuliuscu@scu.edu.cn

DOI: 10.1158/2159-8290.CD-20-0336 Published January 2021

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January 2021
Volume 11, Issue 1

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An Epigenetic Mechanism Underlying Chromosome 17p Deletion–Driven Tumorigenesis