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Cancer Discovery
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Tumor-Infiltrating Natural Killer Cells

Beatriz Cózar, Marco Greppi, Sabrina Carpentier, Emilie Narni-Mancinelli, Laura Chiossone and Eric Vivier
Beatriz Cózar
1Innate Pharma Research Laboratories, Innate Pharma, Marseille, France.
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Marco Greppi
1Innate Pharma Research Laboratories, Innate Pharma, Marseille, France.
2Center of Excellence for Biomedical Research, University of Genoa, Genoa, Italy.
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  • ORCID record for Marco Greppi
Sabrina Carpentier
1Innate Pharma Research Laboratories, Innate Pharma, Marseille, France.
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Emilie Narni-Mancinelli
3Aix Marseille University, CNRS, INSERM, CIML, Marseille, France.
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  • ORCID record for Emilie Narni-Mancinelli
Laura Chiossone
1Innate Pharma Research Laboratories, Innate Pharma, Marseille, France.
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Eric Vivier
1Innate Pharma Research Laboratories, Innate Pharma, Marseille, France.
3Aix Marseille University, CNRS, INSERM, CIML, Marseille, France.
4APHM, Hôpital de la Timone, Service d'Immunologie, Marseille-Immunopôle, Marseille, France.
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  • For correspondence: vivier@ciml.univ-mrs.fr
DOI: 10.1158/2159-8290.CD-20-0655 Published January 2021
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Abstract

Because of their potent antitumor activity and their proinflammatory role, natural killer (NK) cells are at the forefront of efforts to develop immuno-oncologic treatments. NK cells participate in immune responses to tumors by killing target cells and producing cytokines. However, in the immunosuppressive tumor microenvironment, NK cells become dysfunctional through exposure to inhibitory molecules produced by cancer cells, leading to tumor escape. We provide an overview of what is known about NK tumor infiltration and surveillance and about the mechanisms by which NK cells become dysfunctional.

Significance: The functions of tumor-infiltrating NK cells may be impaired. This review aims to describe the various mechanisms by which tumors alter NK-cell functions.

Footnotes

  • Cancer Discov 2021;11:34–44

  • Received May 15, 2020.
  • Revision received August 3, 2020.
  • Accepted August 14, 2020.
  • Published first December 4, 2020.
  • ©2020 American Association for Cancer Research.
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Cancer Discovery: 11 (1)
January 2021
Volume 11, Issue 1
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Tumor-Infiltrating Natural Killer Cells
Beatriz Cózar, Marco Greppi, Sabrina Carpentier, Emilie Narni-Mancinelli, Laura Chiossone and Eric Vivier
Cancer Discov January 1 2021 (11) (1) 34-44; DOI: 10.1158/2159-8290.CD-20-0655

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Tumor-Infiltrating Natural Killer Cells
Beatriz Cózar, Marco Greppi, Sabrina Carpentier, Emilie Narni-Mancinelli, Laura Chiossone and Eric Vivier
Cancer Discov January 1 2021 (11) (1) 34-44; DOI: 10.1158/2159-8290.CD-20-0655
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  • Article
    • Abstract
    • Introduction
    • NK-Cell Infiltration of Solid Tumors
    • Dysfunctional NK Cells
    • The Tumor Microenvironment Affects NK-cell Functions
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