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A Call to Action: Dismantling Racial Injustices in Preclinical Research and Clinical Care of Black Patients Living with Small Cell Lung Cancer

Portia L. Thomas, Chioma J. Madubata, Melinda C. Aldrich, Montessa M. Lee, Taofeek K. Owonikoko, John D. Minna, Charles M. Rudin, Julien Sage and Christine M. Lovly
Portia L. Thomas
1Department of Microbiology, Immunology, and Physiology, School of Medicine, Meharry Medical College, Nashville, Tennessee.
2School of Graduate Studies and Research, Meharry Medical College, Nashville, Tennessee.
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  • ORCID record for Portia L. Thomas
Chioma J. Madubata
3Department of Pediatrics, Stanford University, Stanford, California.
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Melinda C. Aldrich
4Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
5Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee.
6Department of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
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Montessa M. Lee
7Regent University, Virginia Beach, Virginia.
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Taofeek K. Owonikoko
8Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia.
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John D. Minna
9Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas.
10Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas.
11Hamon Center for Therapeutic Oncology Research, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, Texas.
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Charles M. Rudin
12Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
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Julien Sage
3Department of Pediatrics, Stanford University, Stanford, California.
13Department of Genetics, Stanford University, Stanford, California.
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  • For correspondence: christine.lovly@vumc.org julsage@stanford.edu
Christine M. Lovly
14Department of Medicine, Division of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, Tennessee.
15Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
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  • For correspondence: christine.lovly@vumc.org julsage@stanford.edu
DOI: 10.1158/2159-8290.CD-20-1592 Published February 2021
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Abstract

Summary: Small cell lung cancer (SCLC) is an aggressive disease with dismal survival rates and limited therapeutic options. SCLC development is strongly associated with exposure to tobacco carcinogens. However, additional genetic and environmental risk factors that contribute to SCLC pathogenesis are beginning to emerge. Here, we specifically assess disparities pertaining to SCLC in Black populations. In contrast to non–small cell lung cancer, preliminary data suggest that Black individuals may actually be at a lower risk of developing SCLC relative to white individuals. This difference remains unexplained but urgently needs to be verified in larger data sets, because it could provide important new insights and approaches to understanding this recalcitrant tumor. Importantly, little biological information exists on SCLC in Black individuals, and few patient-derived preclinical SCLC models from diverse ancestries are available in the laboratory. Unfortunately, we note strikingly low numbers of Black participants in clinical trials testing new treatments for SCLC. Evidence further indicates that care for patients with SCLC may vary between communities with a large fraction of Black patients and those without. Together, these observations underscore the need to better investigate genetic, environmental, and socioeconomic factors associated with SCLC development, preclinical research, clinical care, and outcomes.

Footnotes

  • Cancer Discov 2021;11:240–4

  • ©2020 American Association for Cancer Research.
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Cancer Discovery: 11 (2)
February 2021
Volume 11, Issue 2
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A Call to Action: Dismantling Racial Injustices in Preclinical Research and Clinical Care of Black Patients Living with Small Cell Lung Cancer
Portia L. Thomas, Chioma J. Madubata, Melinda C. Aldrich, Montessa M. Lee, Taofeek K. Owonikoko, John D. Minna, Charles M. Rudin, Julien Sage and Christine M. Lovly
Cancer Discov February 1 2021 (11) (2) 240-244; DOI: 10.1158/2159-8290.CD-20-1592

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A Call to Action: Dismantling Racial Injustices in Preclinical Research and Clinical Care of Black Patients Living with Small Cell Lung Cancer
Portia L. Thomas, Chioma J. Madubata, Melinda C. Aldrich, Montessa M. Lee, Taofeek K. Owonikoko, John D. Minna, Charles M. Rudin, Julien Sage and Christine M. Lovly
Cancer Discov February 1 2021 (11) (2) 240-244; DOI: 10.1158/2159-8290.CD-20-1592
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  • Article
    • Abstract
    • Introduction
    • SCLC
    • Disparities in SCLC Among Black Individuals
    • Limited Genetic and Genomic Analyses of SCLC in Black Individuals
    • Paucity of SCLC Preclinical Models Derived from Black Patients
    • SCLC Disparities Persist in the Clinic
    • Physicians and Investigators May Influence Disparities in Lung Cancer
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