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Cancer Discovery
Cancer Discovery
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Table of Contents

In This Issue

  • In This Issue
    In This Issue
    Cancer Discov September 1 2012 2 (9) 753-755; DOI:10.1158/2159-8290.CD-ITI12-09

In the Spotlight

  • In the Spotlight
    Whole-Genome Sequencing and Cancer Therapy: Is Too Much Ever Enough?
    Levi A. Garraway and José Baselga
    Cancer Discov September 1 2012 2 (9) 766-768; DOI:10.1158/2159-8290.CD-12-0359

  • In the Spotlight
    A Genetic Snapshot of Small Cell Lung Cancer
    Rafael Rosell and Luciano Wannesson
    Cancer Discov September 1 2012 2 (9) 769-771; DOI:10.1158/2159-8290.CD-12-0346

  • In the Spotlight
    Desmoplasia: A Response or a Niche?
    Yves A. DeClerck
    Cancer Discov September 1 2012 2 (9) 772-774; DOI:10.1158/2159-8290.CD-12-0348

  • In the Spotlight
    Paracrine Signaling between Carcinoma Cells and Mesenchymal Stem Cells Generates Cancer Stem Cell Niche via Epithelial–Mesenchymal Transition
    Kati Räsänen and Meenhard Herlyn
    Cancer Discov September 1 2012 2 (9) 775-777; DOI:10.1158/2159-8290.CD-12-0312

Review

  • Review
    Investigating Metformin for Cancer Prevention and Treatment: The End of the Beginning
    Michael N. Pollak
    Cancer Discov September 1 2012 2 (9) 778-790; DOI:10.1158/2159-8290.CD-12-0263

Research Briefs

  • Research Briefs | Free Article
    BRAFL597 Mutations in Melanoma Are Associated with Sensitivity to MEK Inhibitors
    Kimberly Brown Dahlman, Junfeng Xia, Katherine Hutchinson, Charles Ng, Donald Hucks, Peilin Jia, Mohammad Atefi, Zengliu Su, Suzanne Branch, Pamela L. Lyle, Donna J. Hicks, Viviana Bozon, John A. Glaspy, Neal Rosen, David B. Solit, James L. Netterville, Cindy L. Vnencak-Jones, Jeffrey A. Sosman, Antoni Ribas, Zhongming Zhao and William Pao
    Cancer Discov September 1 2012 2 (9) 791-797; DOI:10.1158/2159-8290.CD-12-0097

    Non-V600E BRAF mutations that are sensitive to MEK inhibition occur in 8% of “BRAF–wild-type” melanomas.

Research Articles

  • Research Articles
    Proteomic Profiling Identifies Dysregulated Pathways in Small Cell Lung Cancer and Novel Therapeutic Targets Including PARP1
    Lauren Averett Byers, Jing Wang, Monique B. Nilsson, Junya Fujimoto, Pierre Saintigny, John Yordy, Uma Giri, Michael Peyton, You Hong Fan, Lixia Diao, Fatemeh Masrorpour, Li Shen, Wenbin Liu, Boris Duchemann, Praveen Tumula, Vikas Bhardwaj, James Welsh, Stephanie Weber, Bonnie S. Glisson, Neda Kalhor, Ignacio I. Wistuba, Luc Girard, Scott M. Lippman, Gordon B. Mills, Kevin R. Coombes, John N. Weinstein, John D. Minna and John V. Heymach
    Cancer Discov September 1 2012 2 (9) 798-811; DOI:10.1158/2159-8290.CD-12-0112

    Small cell lung cancer cells express significantly higher levels of PARP1 than non–small cell lung cancer cells and are highly sensitive to PARP inhibition.

  • Research Articles
    DDX5 Regulates DNA Replication and Is Required for Cell Proliferation in a Subset of Breast Cancer Cells
    Anthony Mazurek, Weijun Luo, Alexander Krasnitz, James Hicks, R. Scott Powers and Bruce Stillman
    Cancer Discov September 1 2012 2 (9) 812-825; DOI:10.1158/2159-8290.CD-12-0116

    DDX5 amplification frequently occurs in breast cancer and promotes cell proliferation by controlling transcription of DNA replication genes.

  • Research Articles
    CD36 Repression Activates a Multicellular Stromal Program Shared by High Mammographic Density and Tumor Tissues
    Rosa Anna DeFilippis, Hang Chang, Nancy Dumont, Joseph T. Rabban, Yunn-Yi Chen, Gerald V. Fontenay, Hal K. Berman, Mona L. Gauthier, Jianxin Zhao, Donglei Hu, James J. Marx, Judy A. Tjoe, Elad Ziv, Maria Febbraio, Karla Kerlikowske, Bahram Parvin and Thea D. Tlsty
    Cancer Discov September 1 2012 2 (9) 826-839; DOI:10.1158/2159-8290.CD-12-0107

    Decreased CD36 expression in mammary stromal cells promotes a pro-oncogenic microenvironment and enhances breast cancer risk.

  • Research Articles
    Cancer-Stimulated Mesenchymal Stem Cells Create a Carcinoma Stem Cell Niche via Prostaglandin E2 Signaling
    Hua-Jung Li, Ferenc Reinhardt, Harvey R. Herschman and Robert A. Weinberg
    Cancer Discov September 1 2012 2 (9) 840-855; DOI:10.1158/2159-8290.CD-12-0101

    Bidirectional signaling between tumor cells and associated mesenchymal stem cells promotes EMT and enhances cancer stem cell formation.

News in Brief

  • News in Brief
    People
    Cancer Discov September 1 2012 2 (9) 756-756; DOI:10.1158/2159-8290.CD-NB2012-097

  • News in Brief
    Everolimus Approved for HR-Positive Breast Cancer
    Cancer Discov September 1 2012 2 (9) 756-756; DOI:10.1158/2159-8290.CD-NB2012-083

  • News in Brief
    University of Kansas Earns NCI Center Designation
    Cancer Discov September 1 2012 2 (9) 756-757; DOI:10.1158/2159-8290.CD-NB2012-085

  • News in Brief
    Studying Cost, Efficacy of Cancer Care
    Cancer Discov September 1 2012 2 (9) 757-757; DOI:10.1158/2159-8290.CD-NB2012-086

  • News in Brief
    CellMiner Integrates NCI-60 Genomic, Pharmacologic Data
    Cancer Discov September 1 2012 2 (9) 757-758; DOI:10.1158/2159-8290.CD-NB2012-082

  • News in Brief
    Industry Gains Incentives for Drugs for Children
    Cancer Discov September 1 2012 2 (9) 758-758; DOI:10.1158/2159-8290.CD-NB2012-079

  • News in Brief
    Noted
    Cancer Discov September 1 2012 2 (9) 758-758; DOI:10.1158/2159-8290.CD-NB2012-098

  • News in Brief
    By the Numbers: What Types of Work Most Interest Life-science PhD Students?
    Cancer Discov September 1 2012 2 (9) 758-758; DOI:10.1158/2159-8290.CD-NB2012-099

  • News in Brief
    Dendreon Downsizes as Provenge Sales Stall
    Cancer Discov September 1 2012 2 (9) OF1-OF1; DOI:10.1158/2159-8290.CD-NB2012-089

  • News in Brief
    Kyprolis Gains Accelerated Approval for Multiple Myeloma
    Cancer Discov September 1 2012 2 (9) OF2-OF2; DOI:10.1158/2159-8290.CD-NB2012-088

  • News in Brief
    Method Yields Single-Cell Transcriptomes
    Cancer Discov September 1 2012 2 (9) OF3-OF3; DOI:10.1158/2159-8290.CD-NB2012-087

  • News in Brief
    A Better Way to Grow Tumor-Initiating Cells?
    Cancer Discov September 1 2012 2 (9) OF4-OF4; DOI:10.1158/2159-8290.CD-NB2012-076

  • News in Brief
    TCGA Findings Spotlight Drivers for Colorectal Cancer
    Cancer Discov September 1 2012 2 (9) OF5-OF5; DOI:10.1158/2159-8290.CD-NB2012-084

  • News in Brief
    Novel Biostatistics May Speed Access to Pediatric Drugs
    Cancer Discov September 1 2012 2 (9) OF6-OF6; DOI:10.1158/2159-8290.CD-NB2012-077

  • News in Brief
    Ultrasound System Finds Tumor Blood Vessels
    Cancer Discov September 1 2012 2 (9) OF7-OF7; DOI:10.1158/2159-8290.CD-NB2012-078

News in Depth

  • News in Depth
    Q&A: Robert Comis and Mitchell Schnall on Trials
    Cancer Discov September 1 2012 2 (9) 759-759; DOI:10.1158/2159-8290.CD-ND2012-033

  • News in Depth
    Immunotherapy Network Launches First Trial
    Cancer Discov September 1 2012 2 (9) 760-760; DOI:10.1158/2159-8290.CD-ND2012-032

Research Watch

  • Angiogenesis

    • Research Watch
      ATM Is Required for Pathologic Angiogenesis
      Cancer Discov September 1 2012 2 (9) OF8-OF8; DOI:10.1158/2159-8290.CD-RW2012-112

  • Apoptosis

    • Research Watch
      Proapoptotic Death Receptor Agonists Act as Vascular Disrupting Agents
      Cancer Discov September 1 2012 2 (9) 762-762; DOI:10.1158/2159-8290.CD-RW2012-108

  • Breast Cancer

    • Research Watch
      PES1 Modulates the Balance between ERα and ERβ in Breast Cancer
      Cancer Discov September 1 2012 2 (9) 763-763; DOI:10.1158/2159-8290.CD-RW2012-117

    • Research Watch
      p110 Isoforms Differentially Regulate PI3K Oncogenic Activity
      Cancer Discov September 1 2012 2 (9) OF9-OF9; DOI:10.1158/2159-8290.CD-RW2012-109

  • Cell Death

    • Research Watch
      Cardiac Glycosides Mediate an Antitumor Immune Response
      Cancer Discov September 1 2012 2 (9) 765-765; DOI:10.1158/2159-8290.CD-RW2012-113

  • Clinical Trials

    • Research Watch
      Pazopanib Has Single-Agent Activity in Advanced Urothelial Cancer
      Cancer Discov September 1 2012 2 (9) 765-765; DOI:10.1158/2159-8290.CD-RW2012-120

  • Drug Discovery

    • Research Watch
      A Selective H3K27me3 Demethylase Inhibitor Blocks Cytokine Production
      Cancer Discov September 1 2012 2 (9) 764-764; DOI:10.1158/2159-8290.CD-RW2012-122

  • Drug Resistance

    • Research Watch
      Heterodimerization of JAK2 with JAK1 or TYK2 Promotes Drug Persistence
      Cancer Discov September 1 2012 2 (9) OF10-OF10; DOI:10.1158/2159-8290.CD-RW2012-118

    • Research Watch
      Stromal Growth Factors Confer Resistance to Targeted Therapies
      Cancer Discov September 1 2012 2 (9) 761-761; DOI:10.1158/2159-8290.CD-RW2012-106

  • Glioblastoma

    • Research Watch
      FGFR–TACC Fusion Proteins Are Oncogenic in Glioblastoma
      Cancer Discov September 1 2012 2 (9) 761-761; DOI:10.1158/2159-8290.CD-RW2012-119

  • Immune Evasion

    • Research Watch
      A Dendritic Cell-Derived Receptor Counteracts Antitumor Immunity
      Cancer Discov September 1 2012 2 (9) 764-764; DOI:10.1158/2159-8290.CD-RW2012-123

  • Immunotherapy

    • Research Watch
      IL-9 and TH9 Cells Confer Tumor Immunity
      Cancer Discov September 1 2012 2 (9) OF11-OF11; DOI:10.1158/2159-8290.CD-RW2012-105

  • Leukemia

    • Research Watch
      The Majority of AML Mutations Are Preexisting Passenger Events
      Cancer Discov September 1 2012 2 (9) OF12-OF12; DOI:10.1158/2159-8290.CD-RW2012-116

    • Research Watch
      Knock-in Mice Show Hematopoietic and Epigenetic Effects of IDH1 Mutation
      Cancer Discov September 1 2012 2 (9) OF13-OF13; DOI:10.1158/2159-8290.CD-RW2012-104

  • Medulloblastoma

    • Research Watch
      Ion Channel Activity Promotes Mitotic Entry and Tumor Cell Growth
      Cancer Discov September 1 2012 2 (9) 763-763; DOI:10.1158/2159-8290.CD-RW2012-124

  • Metabolism

    • Research Watch
      TBC1D7 Is a Core Subunit of the TSC1–TSC2 Complex
      Cancer Discov September 1 2012 2 (9) OF14-OF14; DOI:10.1158/2159-8290.CD-RW2012-110

  • Metastasis

    • Research Watch
      An Innate Immune Pathway Regulates Breast Cancer Metastasis
      Cancer Discov September 1 2012 2 (9) OF15-OF15; DOI:10.1158/2159-8290.CD-RW2012-115

    • Research Watch
      CCL2-CCR2 Chemokine Signaling Facilitates Tumor Cell Extravasation
      Cancer Discov September 1 2012 2 (9) OF16-OF16; DOI:10.1158/2159-8290.CD-RW2012-107

  • Signaling

    • Research Watch
      Acetylation Modulates SKP2 Oncogenic Signaling
      Cancer Discov September 1 2012 2 (9) OF17-OF17; DOI:10.1158/2159-8290.CD-RW2012-103

  • Stem Cells

    • Research Watch
      BLK Selectively Regulates Leukemic Stem Cells in CML
      Cancer Discov September 1 2012 2 (9) OF18-OF18; DOI:10.1158/2159-8290.CD-RW2012-111

  • Systems Biology

    • Research Watch
      Tumor Virus-Induced Host Network Perturbations Identify Cancer Genes
      Cancer Discov September 1 2012 2 (9) OF19-OF19; DOI:10.1158/2159-8290.CD-RW2012-114

  • Tumorigenesis

    • Research Watch
      HSF1 Plays Distinct Roles in Heat Shock and Cancer
      Cancer Discov September 1 2012 2 (9) OF20-OF20; DOI:10.1158/2159-8290.CD-RW2012-125

  • Vaccines

    • Research Watch
      Vaccine-Specific Immune Responses Correlate with Clinical Benefit
      Cancer Discov September 1 2012 2 (9) 762-762; DOI:10.1158/2159-8290.CD-RW2012-121

Correction

  • Correction
    Correction: Gene Signatures Associated with Mouse Postnatal Hindbrain Neural Stem Cells and Medulloblastoma Cancer Stem Cells Identify Novel Molecular Mediators and Predict Human Medulloblastoma Molecular Classification
    Cancer Discov September 1 2012 2 (9) 856-856; DOI:10.1158/2159-8290.CD-12-0284

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Cancer Discovery: 2 (9)
September 2012
Volume 2, Issue 9
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