Cancer Discovery: 2 (9)

In This Issue

In This Issue

In This Issue

Cancer Discov September 1 2012 2 (9) 753-755; DOI:10.1158/2159-8290.CD-ITI12-09

In the Spotlight

In the Spotlight

Whole-Genome Sequencing and Cancer Therapy: Is Too Much Ever Enough?

Levi A. Garraway and José Baselga

Cancer Discov September 1 2012 2 (9) 766-768; DOI:10.1158/2159-8290.CD-12-0359
In the Spotlight

A Genetic Snapshot of Small Cell Lung Cancer

Rafael Rosell and Luciano Wannesson

Cancer Discov September 1 2012 2 (9) 769-771; DOI:10.1158/2159-8290.CD-12-0346
In the Spotlight

Desmoplasia: A Response or a Niche?

Yves A. DeClerck

Cancer Discov September 1 2012 2 (9) 772-774; DOI:10.1158/2159-8290.CD-12-0348
In the Spotlight

Paracrine Signaling between Carcinoma Cells and Mesenchymal Stem Cells Generates Cancer Stem Cell Niche via Epithelial–Mesenchymal Transition

Kati Räsänen and Meenhard Herlyn

Cancer Discov September 1 2012 2 (9) 775-777; DOI:10.1158/2159-8290.CD-12-0312

Review

Review

Investigating Metformin for Cancer Prevention and Treatment: The End of the Beginning

Michael N. Pollak

Cancer Discov September 1 2012 2 (9) 778-790; DOI:10.1158/2159-8290.CD-12-0263

Research Briefs

Research Briefs | Free Article

BRAF^L597 Mutations in Melanoma Are Associated with Sensitivity to MEK Inhibitors

Kimberly Brown Dahlman, Junfeng Xia, Katherine Hutchinson, Charles Ng, Donald Hucks, Peilin Jia, Mohammad Atefi, Zengliu Su, Suzanne Branch, Pamela L. Lyle, Donna J. Hicks, Viviana Bozon, John A. Glaspy, Neal Rosen, David B. Solit, James L. Netterville, Cindy L. Vnencak-Jones, Jeffrey A. Sosman, Antoni Ribas, Zhongming Zhao and William Pao

Cancer Discov September 1 2012 2 (9) 791-797; DOI:10.1158/2159-8290.CD-12-0097

Non-V600E BRAF mutations that are sensitive to MEK inhibition occur in 8% of “BRAF–wild-type” melanomas.

Research Articles

Research Articles

Proteomic Profiling Identifies Dysregulated Pathways in Small Cell Lung Cancer and Novel Therapeutic Targets Including PARP1

Lauren Averett Byers, Jing Wang, Monique B. Nilsson, Junya Fujimoto, Pierre Saintigny, John Yordy, Uma Giri, Michael Peyton, You Hong Fan, Lixia Diao, Fatemeh Masrorpour, Li Shen, Wenbin Liu, Boris Duchemann, Praveen Tumula, Vikas Bhardwaj, James Welsh, Stephanie Weber, Bonnie S. Glisson, Neda Kalhor, Ignacio I. Wistuba, Luc Girard, Scott M. Lippman, Gordon B. Mills, Kevin R. Coombes, John N. Weinstein, John D. Minna and John V. Heymach

Cancer Discov September 1 2012 2 (9) 798-811; DOI:10.1158/2159-8290.CD-12-0112

Small cell lung cancer cells express significantly higher levels of PARP1 than non–small cell lung cancer cells and are highly sensitive to PARP inhibition.
Research Articles

DDX5 Regulates DNA Replication and Is Required for Cell Proliferation in a Subset of Breast Cancer Cells

Anthony Mazurek, Weijun Luo, Alexander Krasnitz, James Hicks, R. Scott Powers and Bruce Stillman

Cancer Discov September 1 2012 2 (9) 812-825; DOI:10.1158/2159-8290.CD-12-0116

DDX5 amplification frequently occurs in breast cancer and promotes cell proliferation by controlling transcription of DNA replication genes.
Research Articles

CD36 Repression Activates a Multicellular Stromal Program Shared by High Mammographic Density and Tumor Tissues

Rosa Anna DeFilippis, Hang Chang, Nancy Dumont, Joseph T. Rabban, Yunn-Yi Chen, Gerald V. Fontenay, Hal K. Berman, Mona L. Gauthier, Jianxin Zhao, Donglei Hu, James J. Marx, Judy A. Tjoe, Elad Ziv, Maria Febbraio, Karla Kerlikowske, Bahram Parvin and Thea D. Tlsty

Cancer Discov September 1 2012 2 (9) 826-839; DOI:10.1158/2159-8290.CD-12-0107

Decreased CD36 expression in mammary stromal cells promotes a pro-oncogenic microenvironment and enhances breast cancer risk.
Research Articles

Cancer-Stimulated Mesenchymal Stem Cells Create a Carcinoma Stem Cell Niche via Prostaglandin E₂ Signaling

Hua-Jung Li, Ferenc Reinhardt, Harvey R. Herschman and Robert A. Weinberg

Cancer Discov September 1 2012 2 (9) 840-855; DOI:10.1158/2159-8290.CD-12-0101

Bidirectional signaling between tumor cells and associated mesenchymal stem cells promotes EMT and enhances cancer stem cell formation.

News in Brief

News in Brief

People

Cancer Discov September 1 2012 2 (9) 756-756; DOI:10.1158/2159-8290.CD-NB2012-097
News in Brief

Everolimus Approved for HR-Positive Breast Cancer

Cancer Discov September 1 2012 2 (9) 756-756; DOI:10.1158/2159-8290.CD-NB2012-083
News in Brief

University of Kansas Earns NCI Center Designation

Cancer Discov September 1 2012 2 (9) 756-757; DOI:10.1158/2159-8290.CD-NB2012-085
News in Brief

Studying Cost, Efficacy of Cancer Care

Cancer Discov September 1 2012 2 (9) 757-757; DOI:10.1158/2159-8290.CD-NB2012-086
News in Brief

CellMiner Integrates NCI-60 Genomic, Pharmacologic Data

Cancer Discov September 1 2012 2 (9) 757-758; DOI:10.1158/2159-8290.CD-NB2012-082
News in Brief

Industry Gains Incentives for Drugs for Children

Cancer Discov September 1 2012 2 (9) 758-758; DOI:10.1158/2159-8290.CD-NB2012-079
News in Brief

Noted

Cancer Discov September 1 2012 2 (9) 758-758; DOI:10.1158/2159-8290.CD-NB2012-098
News in Brief

By the Numbers: What Types of Work Most Interest Life-science PhD Students?

Cancer Discov September 1 2012 2 (9) 758-758; DOI:10.1158/2159-8290.CD-NB2012-099
News in Brief

Dendreon Downsizes as Provenge Sales Stall

Cancer Discov September 1 2012 2 (9) OF1-OF1; DOI:10.1158/2159-8290.CD-NB2012-089
News in Brief

Kyprolis Gains Accelerated Approval for Multiple Myeloma

Cancer Discov September 1 2012 2 (9) OF2-OF2; DOI:10.1158/2159-8290.CD-NB2012-088
News in Brief

Method Yields Single-Cell Transcriptomes

Cancer Discov September 1 2012 2 (9) OF3-OF3; DOI:10.1158/2159-8290.CD-NB2012-087
News in Brief

A Better Way to Grow Tumor-Initiating Cells?

Cancer Discov September 1 2012 2 (9) OF4-OF4; DOI:10.1158/2159-8290.CD-NB2012-076
News in Brief

TCGA Findings Spotlight Drivers for Colorectal Cancer

Cancer Discov September 1 2012 2 (9) OF5-OF5; DOI:10.1158/2159-8290.CD-NB2012-084
News in Brief

Novel Biostatistics May Speed Access to Pediatric Drugs

Cancer Discov September 1 2012 2 (9) OF6-OF6; DOI:10.1158/2159-8290.CD-NB2012-077
News in Brief

Ultrasound System Finds Tumor Blood Vessels

Cancer Discov September 1 2012 2 (9) OF7-OF7; DOI:10.1158/2159-8290.CD-NB2012-078

News in Depth

News in Depth

Q&A: Robert Comis and Mitchell Schnall on Trials

Cancer Discov September 1 2012 2 (9) 759-759; DOI:10.1158/2159-8290.CD-ND2012-033
News in Depth

Immunotherapy Network Launches First Trial

Cancer Discov September 1 2012 2 (9) 760-760; DOI:10.1158/2159-8290.CD-ND2012-032

Research Watch

Angiogenesis
- Research Watch
  
  ATM Is Required for Pathologic Angiogenesis
  
  Cancer Discov September 1 2012 2 (9) OF8-OF8; DOI:10.1158/2159-8290.CD-RW2012-112
Apoptosis
- Research Watch
  
  Proapoptotic Death Receptor Agonists Act as Vascular Disrupting Agents
  
  Cancer Discov September 1 2012 2 (9) 762-762; DOI:10.1158/2159-8290.CD-RW2012-108
Breast Cancer
- Research Watch
  
  PES1 Modulates the Balance between ERα and ERβ in Breast Cancer
  
  Cancer Discov September 1 2012 2 (9) 763-763; DOI:10.1158/2159-8290.CD-RW2012-117
- Research Watch
  
  p110 Isoforms Differentially Regulate PI3K Oncogenic Activity
  
  Cancer Discov September 1 2012 2 (9) OF9-OF9; DOI:10.1158/2159-8290.CD-RW2012-109
Cell Death
- Research Watch
  
  Cardiac Glycosides Mediate an Antitumor Immune Response
  
  Cancer Discov September 1 2012 2 (9) 765-765; DOI:10.1158/2159-8290.CD-RW2012-113
Clinical Trials
- Research Watch
  
  Pazopanib Has Single-Agent Activity in Advanced Urothelial Cancer
  
  Cancer Discov September 1 2012 2 (9) 765-765; DOI:10.1158/2159-8290.CD-RW2012-120
Drug Discovery
- Research Watch
  
  A Selective H3K27me3 Demethylase Inhibitor Blocks Cytokine Production
  
  Cancer Discov September 1 2012 2 (9) 764-764; DOI:10.1158/2159-8290.CD-RW2012-122
Drug Resistance
- Research Watch
  
  Heterodimerization of JAK2 with JAK1 or TYK2 Promotes Drug Persistence
  
  Cancer Discov September 1 2012 2 (9) OF10-OF10; DOI:10.1158/2159-8290.CD-RW2012-118
- Research Watch
  
  Stromal Growth Factors Confer Resistance to Targeted Therapies
  
  Cancer Discov September 1 2012 2 (9) 761-761; DOI:10.1158/2159-8290.CD-RW2012-106
Glioblastoma
- Research Watch
  
  FGFR–TACC Fusion Proteins Are Oncogenic in Glioblastoma
  
  Cancer Discov September 1 2012 2 (9) 761-761; DOI:10.1158/2159-8290.CD-RW2012-119
Immune Evasion
- Research Watch
  
  A Dendritic Cell-Derived Receptor Counteracts Antitumor Immunity
  
  Cancer Discov September 1 2012 2 (9) 764-764; DOI:10.1158/2159-8290.CD-RW2012-123
Immunotherapy
- Research Watch
  
  IL-9 and T_H9 Cells Confer Tumor Immunity
  
  Cancer Discov September 1 2012 2 (9) OF11-OF11; DOI:10.1158/2159-8290.CD-RW2012-105
Leukemia
- Research Watch
  
  The Majority of AML Mutations Are Preexisting Passenger Events
  
  Cancer Discov September 1 2012 2 (9) OF12-OF12; DOI:10.1158/2159-8290.CD-RW2012-116
- Research Watch
  
  Knock-in Mice Show Hematopoietic and Epigenetic Effects of IDH1 Mutation
  
  Cancer Discov September 1 2012 2 (9) OF13-OF13; DOI:10.1158/2159-8290.CD-RW2012-104
Medulloblastoma
- Research Watch
  
  Ion Channel Activity Promotes Mitotic Entry and Tumor Cell Growth
  
  Cancer Discov September 1 2012 2 (9) 763-763; DOI:10.1158/2159-8290.CD-RW2012-124
Metabolism
- Research Watch
  
  TBC1D7 Is a Core Subunit of the TSC1–TSC2 Complex
  
  Cancer Discov September 1 2012 2 (9) OF14-OF14; DOI:10.1158/2159-8290.CD-RW2012-110
Metastasis
- Research Watch
  
  An Innate Immune Pathway Regulates Breast Cancer Metastasis
  
  Cancer Discov September 1 2012 2 (9) OF15-OF15; DOI:10.1158/2159-8290.CD-RW2012-115
- Research Watch
  
  CCL2-CCR2 Chemokine Signaling Facilitates Tumor Cell Extravasation
  
  Cancer Discov September 1 2012 2 (9) OF16-OF16; DOI:10.1158/2159-8290.CD-RW2012-107
Signaling
- Research Watch
  
  Acetylation Modulates SKP2 Oncogenic Signaling
  
  Cancer Discov September 1 2012 2 (9) OF17-OF17; DOI:10.1158/2159-8290.CD-RW2012-103
Stem Cells
- Research Watch
  
  BLK Selectively Regulates Leukemic Stem Cells in CML
  
  Cancer Discov September 1 2012 2 (9) OF18-OF18; DOI:10.1158/2159-8290.CD-RW2012-111
Systems Biology
- Research Watch
  
  Tumor Virus-Induced Host Network Perturbations Identify Cancer Genes
  
  Cancer Discov September 1 2012 2 (9) OF19-OF19; DOI:10.1158/2159-8290.CD-RW2012-114
Tumorigenesis
- Research Watch
  
  HSF1 Plays Distinct Roles in Heat Shock and Cancer
  
  Cancer Discov September 1 2012 2 (9) OF20-OF20; DOI:10.1158/2159-8290.CD-RW2012-125
Vaccines
- Research Watch
  
  Vaccine-Specific Immune Responses Correlate with Clinical Benefit
  
  Cancer Discov September 1 2012 2 (9) 762-762; DOI:10.1158/2159-8290.CD-RW2012-121

Correction

Correction

Correction: Gene Signatures Associated with Mouse Postnatal Hindbrain Neural Stem Cells and Medulloblastoma Cancer Stem Cells Identify Novel Molecular Mediators and Predict Human Medulloblastoma Molecular Classification

Cancer Discov September 1 2012 2 (9) 856-856; DOI:10.1158/2159-8290.CD-12-0284

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Table of Contents

In This Issue

In the Spotlight

Review

Research Briefs

Research Articles

News in Brief

News in Depth

Research Watch

Angiogenesis

Apoptosis

Breast Cancer

Cell Death

Clinical Trials

Drug Discovery

Drug Resistance

Glioblastoma

Immune Evasion

Immunotherapy

Leukemia

Medulloblastoma

Metabolism

Metastasis

Signaling

Stem Cells

Systems Biology

Tumorigenesis

Vaccines

Correction

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