In This Issue
Cancer Discov September 1 2012 2 (9) 753-755; DOI:10.1158/2159-8290.CD-ITI12-09
Non-V600E BRAF mutations that are sensitive to MEK inhibition occur in 8% of “BRAF–wild-type” melanomas.
Small cell lung cancer cells express significantly higher levels of PARP1 than non–small cell lung cancer cells and are highly sensitive to PARP inhibition.
DDX5 amplification frequently occurs in breast cancer and promotes cell proliferation by controlling transcription of DNA replication genes.
Decreased CD36 expression in mammary stromal cells promotes a pro-oncogenic microenvironment and enhances breast cancer risk.
Bidirectional signaling between tumor cells and associated mesenchymal stem cells promotes EMT and enhances cancer stem cell formation.