Mechanisms of Resistance to PARP Inhibitors—Three and Counting

Abstract

Summary: Given the malleable nature of cancer cells, we should expect, and do see, the development of resistance to any new chemotherapeutic agent. Models that help us understand how this happens are a first step to better and more effective chemotherapeutics. Cancer Discov; 3(1); 20–3. ©2012 AACR.

See related article by Jaspers et al., p. 68