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Cancer Discovery
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What a Tangled Web We Weave: Emerging Resistance Mechanisms to Inhibition of the Phosphoinositide 3-Kinase Pathway

Samuel J. Klempner, Andrea P. Myers and Lewis C. Cantley
Samuel J. Klempner
1Division of Hematology-Oncology, University of California Irvine Medical Center, Orange, California; 2Division of Signal Transduction, Beth Israel Deaconess Medical Center; 3Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; and 4Department of Medicine, Weill Cornell Medical College, New York, New York
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Andrea P. Myers
1Division of Hematology-Oncology, University of California Irvine Medical Center, Orange, California; 2Division of Signal Transduction, Beth Israel Deaconess Medical Center; 3Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; and 4Department of Medicine, Weill Cornell Medical College, New York, New York
1Division of Hematology-Oncology, University of California Irvine Medical Center, Orange, California; 2Division of Signal Transduction, Beth Israel Deaconess Medical Center; 3Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; and 4Department of Medicine, Weill Cornell Medical College, New York, New York
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Lewis C. Cantley
1Division of Hematology-Oncology, University of California Irvine Medical Center, Orange, California; 2Division of Signal Transduction, Beth Israel Deaconess Medical Center; 3Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; and 4Department of Medicine, Weill Cornell Medical College, New York, New York
1Division of Hematology-Oncology, University of California Irvine Medical Center, Orange, California; 2Division of Signal Transduction, Beth Israel Deaconess Medical Center; 3Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; and 4Department of Medicine, Weill Cornell Medical College, New York, New York
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DOI: 10.1158/2159-8290.CD-13-0063 Published December 2013
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Article Information

Volume 3, Issue 12, pp. 1345-1354

DOI 
https://doi.org/10.1158/2159-8290.CD-13-0063
PubMed 
24265156

Published By 
American Association for Cancer Research
Print ISSN 
2159-8274
Online ISSN 
2159-8290
History 
  • Received February 8, 2013
  • Revision received August 21, 2013
  • Accepted August 22, 2013
  • Published first November 21, 2013.

Article Versions

  • Previous version (November 21, 2013 - 07:11).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2013 American Association for Cancer Research.

Author Information

  1. Samuel J. Klempner1,
  2. Andrea P. Myers2,3 and
  3. Lewis C. Cantley2,4
  1. Authors' Affiliations: 1Division of Hematology-Oncology, University of California Irvine Medical Center, Orange, California; 2Division of Signal Transduction, Beth Israel Deaconess Medical Center; 3Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; and 4Department of Medicine, Weill Cornell Medical College, New York, New York
  1. Corresponding Author:
    Lewis C. Cantley, Weill Cornell Medical College, 1300 York Avenue, Box 8, New York, NY 10065. Phone: 646-962-2900; Fax: 617-667-0957; E-mail: LCantley{at}med.cornell.edu
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Cancer Discovery: 3 (12)
December 2013
Volume 3, Issue 12
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What a Tangled Web We Weave: Emerging Resistance Mechanisms to Inhibition of the Phosphoinositide 3-Kinase Pathway
Samuel J. Klempner, Andrea P. Myers and Lewis C. Cantley
Cancer Discov December 1 2013 (3) (12) 1345-1354; DOI: 10.1158/2159-8290.CD-13-0063

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What a Tangled Web We Weave: Emerging Resistance Mechanisms to Inhibition of the Phosphoinositide 3-Kinase Pathway
Samuel J. Klempner, Andrea P. Myers and Lewis C. Cantley
Cancer Discov December 1 2013 (3) (12) 1345-1354; DOI: 10.1158/2159-8290.CD-13-0063
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    • Abstract
    • Introduction
    • Canonical Class IA PI3K Signaling
    • IRS-1 AND IGFR-I
    • FOXO-Mediated Mechanisms
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    • Androgen Receptor Feedback
    • c-MYC and Cap-Dependent Translation
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