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Volume 3, Issue 12, pp. 1345-1354
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History
- Received February 8, 2013
- Revision received August 21, 2013
- Accepted August 22, 2013
- Published first November 21, 2013.
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- Previous version (November 21, 2013 - 07:11).
- You are viewing the most recent version of this article.
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©2013 American Association for Cancer Research.
Author Information
- Authors' Affiliations: 1Division of Hematology-Oncology, University of California Irvine Medical Center, Orange, California; 2Division of Signal Transduction, Beth Israel Deaconess Medical Center; 3Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; and 4Department of Medicine, Weill Cornell Medical College, New York, New York
- Corresponding Author:
Lewis C. Cantley, Weill Cornell Medical College, 1300 York Avenue, Box 8, New York, NY 10065. Phone: 646-962-2900; Fax: 617-667-0957; E-mail: LCantley{at}med.cornell.edu
December 2013
Volume 3, Issue 12
Volume 3, Issue 12
What a Tangled Web We Weave: Emerging Resistance Mechanisms to Inhibition of the Phosphoinositide 3-Kinase Pathway
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- Article
- Abstract
- Introduction
- Canonical Class IA PI3K Signaling
- IRS-1 AND IGFR-I
- FOXO-Mediated Mechanisms
- β-Catenin
- Androgen Receptor Feedback
- c-MYC and Cap-Dependent Translation
- Clinical Implications
- Conclusions
- Disclosure of Potential Conflicts of Interest
- Authors' Contributions
- Grant Support
- Acknowledgments
- References
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