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Cancer Discovery
Cancer Discovery
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Table of Contents

In This Issue

  • In This Issue
    In This Issue
    Cancer Discov May 1 2013 3 (5) 471-473; DOI:10.1158/2159-8290.CD-ITI13-05

In the Spotlight

  • In the Spotlight
    G34, Another Connection between MYCN and a Pediatric Tumor
    Miller Huang and William A. Weiss
    Cancer Discov May 1 2013 3 (5) 484-486; DOI:10.1158/2159-8290.CD-13-0126

  • In the Spotlight
    Déjà Vu: EGF Receptors Drive Resistance to BRAF Inhibitors
    Maria Romina Girotti and Richard Marais
    Cancer Discov May 1 2013 3 (5) 487-490; DOI:10.1158/2159-8290.CD-13-0131

  • In the Spotlight
    Two Is Better Than One: Combining IGF1R and MEK Blockade as a Promising Novel Treatment Strategy Against KRAS-Mutant Lung Cancer
    Ron Chen and E. Alejandro Sweet-Cordero
    Cancer Discov May 1 2013 3 (5) 491-493; DOI:10.1158/2159-8290.CD-13-0128

  • In the Spotlight
    Discovering What Makes STAT Signaling TYK in T-ALL
    Lorena Fontan and Ari Melnick
    Cancer Discov May 1 2013 3 (5) 494-496; DOI:10.1158/2159-8290.CD-13-0123

In Focus

  • In Focus
    A Tale of Metabolites: The Cross-Talk between Chromatin and Energy Metabolism
    Barbara Martinez-Pastor, Claudia Cosentino and Raul Mostoslavsky
    Cancer Discov May 1 2013 3 (5) 497-501; DOI:10.1158/2159-8290.CD-13-0059

Review

  • Review
    Molecular Dissection of Microsatellite Instable Colorectal Cancer
    Eduardo Vilar and Josep Tabernero
    Cancer Discov May 1 2013 3 (5) 502-511; DOI:10.1158/2159-8290.CD-12-0471

Research Brief

  • Research Brief
    Histone H3.3 Mutations Drive Pediatric Glioblastoma through Upregulation of MYCN
    Lynn Bjerke, Alan Mackay, Meera Nandhabalan, Anna Burford, Alexa Jury, Sergey Popov, Dorine A. Bax, Diana Carvalho, Kathryn R. Taylor, Maria Vinci, Ilirjana Bajrami, Imelda M. McGonnell, Christopher J. Lord, Rui M. Reis, Darren Hargrave, Alan Ashworth, Paul Workman and Chris Jones
    Cancer Discov May 1 2013 3 (5) 512-519; DOI:10.1158/2159-8290.CD-12-0426

    Histone variant H3.3 glycine-34 mutations induce differential genome-wide histone H3 lysine 36 trimethylation and lead to upregulation of MYCN in the developing forebrain.

Research Articles

  • Research Articles | AuthorChoice
    Relief of Feedback Inhibition of HER3 Transcription by RAF and MEK Inhibitors Attenuates Their Antitumor Effects in BRAF-Mutant Thyroid Carcinomas
    Cristina Montero-Conde, Sergio Ruiz-Llorente, Jose M. Dominguez, Jeffrey A. Knauf, Agnes Viale, Eric J. Sherman, Mabel Ryder, Ronald A. Ghossein, Neal Rosen and James A. Fagin
    Cancer Discov May 1 2013 3 (5) 520-533; DOI:10.1158/2159-8290.CD-12-0531

    Lineage-specific HER3 upregulation and ligand-dependent HER2/HER3 activation confer resistance to MAPK pathway inhibitors in BRAF-mutant thyroid cancer cells.

  • Research Articles
    De-Repression of PDGFRβ Transcription Promotes Acquired Resistance to EGFR Tyrosine Kinase Inhibitors in Glioblastoma Patients
    David Akhavan, Alexandra L. Pourzia, Alex A. Nourian, Kevin J. Williams, David Nathanson, Ivan Babic, Genaro R. Villa, Kazuhiro Tanaka, Ali Nael, Huijun Yang, Julie Dang, Harry V. Vinters, William H. Yong, Mitchell Flagg, Fuyuhiko Tamanoi, Takashi Sasayama, C. David James, Harley I. Kornblum, Tim F. Cloughesy, Webster K. Cavenee, Steven J. Bensinger and Paul S. Mischel
    Cancer Discov May 1 2013 3 (5) 534-547; DOI:10.1158/2159-8290.CD-12-0502

    Transcriptional derepression of PDGFRβ in response to EGFR inhibition renders EGFR-mutant glioblastomas dependent on PDGFRβ for survival.

  • Research Articles
    Coordinate Direct Input of Both KRAS and IGF1 Receptor to Activation of PI3 kinase in KRAS-Mutant Lung Cancer
    Miriam Molina-Arcas, David C. Hancock, Clare Sheridan, Madhu S. Kumar and Julian Downward
    Cancer Discov May 1 2013 3 (5) 548-563; DOI:10.1158/2159-8290.CD-12-0446

    KRAS-mutant NSCLC cells are selectively sensitive to inhibition of IGF1R, which is required for KRAS-mediated activation of PI3K signaling.

  • Research Articles
    TYK2–STAT1–BCL2 Pathway Dependence in T-cell Acute Lymphoblastic Leukemia
    Takaomi Sanda, Jeffrey W. Tyner, Alejandro Gutierrez, Vu N. Ngo, Jason Glover, Bill H. Chang, Arla Yost, Wenxue Ma, Angela G. Fleischman, Wenjun Zhou, Yandan Yang, Maria Kleppe, Yebin Ahn, Jessica Tatarek, Michelle A. Kelliher, Donna S. Neuberg, Ross L. Levine, Richard Moriggl, Mathias Müller, Nathanael S. Gray, Catriona H.M. Jamieson, Andrew P. Weng, Louis M. Staudt, Brian J. Druker and A. Thomas Look
    Cancer Discov May 1 2013 3 (5) 564-577; DOI:10.1158/2159-8290.CD-12-0504

    Activation of tyrosine kinase 2 (TYK2) by mutation or autocrine interleukin-10 signaling promotes T-ALL cell survival through activation of STAT1 and upregulation of BCL2.

  • Research Articles
    Bone Marrow–Derived Gr1+ Cells Can Generate a Metastasis-Resistant Microenvironment Via Induced Secretion of Thrombospondin-1
    Raúl Catena, Nandita Bhattacharya, Tina El Rayes, Suming Wang, Hyejin Choi, Dingcheng Gao, Seongho Ryu, Natasha Joshi, Diane Bielenberg, Sharrell B. Lee, Svein A. Haukaas, Karsten Gravdal, Ole J. Halvorsen, Lars A. Akslen, Randolph S. Watnick and Vivek Mittal
    Cancer Discov May 1 2013 3 (5) 578-589; DOI:10.1158/2159-8290.CD-12-0476

    Metastasis-incompetent tumors systemically reprogram bone marrow–derived myeloid cells in the premetastatic niche to produce TSP-1 to suppress metastatic outgrowth.

News in Brief

  • News in Brief
    People
    Cancer Discov May 1 2013 3 (5) 474-474; DOI:10.1158/2159-8290.CD-NB2013-041

  • News in Brief
    Varmus: “Let's Do the Best We Can”
    Cancer Discov May 1 2013 3 (5) 474-474; DOI:10.1158/2159-8290.CD-NB2013-056

  • News in Brief
    AstraZeneca Reorganizes Drug Research
    Cancer Discov May 1 2013 3 (5) 474-474; DOI:10.1158/2159-8290.CD-NB2013-046

  • News in Brief
    TCGA Sees Heterogeneity in Head and Neck Cancers
    Cancer Discov May 1 2013 3 (5) 475-476; DOI:10.1158/2159-8290.CD-NB2013-049

  • News in Brief
    Noted
    Cancer Discov May 1 2013 3 (5) 475-475; DOI:10.1158/2159-8290.CD-NB2013-042

  • News in Brief
    Screening for Mutations in Circulating DNA
    Cancer Discov May 1 2013 3 (5) 476-476; DOI:10.1158/2159-8290.CD-NB2013-048

  • News in Brief
    AKT Inhibitors Take Steps Forward
    Cancer Discov May 1 2013 3 (5) OF1-OF1; DOI:10.1158/2159-8290.CD-NB2013-053

  • News in Brief
    BRCA1/2 Status May Predict Prognosis
    Cancer Discov May 1 2013 3 (5) OF2-OF2; DOI:10.1158/2159-8290.CD-NB2013-052

  • News in Brief
    PI3K Inhibitor Shows Promise in Early Trial
    Cancer Discov May 1 2013 3 (5) OF3-OF3; DOI:10.1158/2159-8290.CD-NB2013-050

  • News in Brief
    Drug Combo Gets Second Wind in Treating BRCA-Deficient Tumors
    Cancer Discov May 1 2013 3 (5) OF4-OF4; DOI:10.1158/2159-8290.CD-NB2013-054

  • News in Brief
    Antibody–Drug Conjugate Hits Elusive HER2+ Breast Tumors
    Cancer Discov May 1 2013 3 (5) OF5-OF5; DOI:10.1158/2159-8290.CD-NB2013-051

  • News in Brief
    Teaming Up for a Companion Diagnostic
    Cancer Discov May 1 2013 3 (5) OF6-OF6; DOI:10.1158/2159-8290.CD-NB2013-047

  • News in Brief
    AACR Academy Launched
    Cancer Discov May 1 2013 3 (5) OF7-OF7; DOI:10.1158/2159-8290.CD-NB2013-045

  • News in Brief
    Agent Approved for Finding Cancer Lymph Nodes
    Cancer Discov May 1 2013 3 (5) OF8-OF8; DOI:10.1158/2159-8290.CD-NB2013-044

  • News in Brief
    Devil Is in Details for Data Transparency
    Cancer Discov May 1 2013 3 (5) OF9-OF9; DOI:10.1158/2159-8290.CD-NB2013-043

  • News in Brief
    Old Drug Learns New Tricks for Lymphomas
    Cancer Discov May 1 2013 3 (5) OF10-OF10; DOI:10.1158/2159-8290.CD-NB2013-038

  • News in Brief
    Startup Bets on Cancer Immunotherapy
    Cancer Discov May 1 2013 3 (5) OF11-OF11; DOI:10.1158/2159-8290.CD-NB2013-037

News in Depth

  • News in Depth
    Q&A: Powel Brown on Cancer Prevention Research
    Cancer Discov May 1 2013 3 (5) 477-477; DOI:10.1158/2159-8290.CD-ND2013-011

  • News in Depth
    Two Drugs Deemed Breakthrough Therapies
    Cancer Discov May 1 2013 3 (5) 478-478; DOI:10.1158/2159-8290.CD-ND2013-008

Research Watch

  • Biomarkers

    • Research Watch
      Circulating Tumor DNA Is a Biomarker of Metastatic Breast Cancer
      Cancer Discov May 1 2013 3 (5) 482-482; DOI:10.1158/2159-8290.CD-RW2013-063

  • Drug Resistance

    • Research Watch
      Enhanced ERBB3 Signaling Promotes Resistance in Melanoma
      Cancer Discov May 1 2013 3 (5) 479-479; DOI:10.1158/2159-8290.CD-RW2013-077

  • Glioma

    • Research Watch
      Histone H3 Lysine 27 Mutations Block Methylation
      Cancer Discov May 1 2013 3 (5) OF12-OF12; DOI:10.1158/2159-8290.CD-RW2013-074

  • Immunotherapy

    • Research Watch
      Chimeric Antigen Receptor-Modified T Cells Show Activity in Pediatric ALL
      Cancer Discov May 1 2013 3 (5) OF13-OF13; DOI:10.1158/2159-8290.CD-RW2013-071

    • Research Watch
      CAR-Modified T Cells Have Antitumor Activity in Refractory Adult B-ALL
      Cancer Discov May 1 2013 3 (5) 481-481; DOI:10.1158/2159-8290.CD-RW2013-067

  • Leukemia

    • Research Watch
      POT1 Shelterin Complex Mutations Promote Genomic Instability in CLL
      Cancer Discov May 1 2013 3 (5) 483-483; DOI:10.1158/2159-8290.CD-RW2013-065

    • Research Watch
      PHF8 Mediates ATRA Sensitivity in Acute Promyelocytic Leukemia
      Cancer Discov May 1 2013 3 (5) OF14-OF14; DOI:10.1158/2159-8290.CD-RW2013-064

  • Melanoma

    • Research Watch
      Oncogenic BRAF Triggers Metabolic Reprogramming in Melanoma
      Cancer Discov May 1 2013 3 (5) OF15-OF15; DOI:10.1158/2159-8290.CD-RW2013-061

  • Metabolism

    • Research Watch
      SIRT4 Controls the Cellular Metabolic Response to DNA Damage
      Cancer Discov May 1 2013 3 (5) 480-480; DOI:10.1158/2159-8290.CD-RW2013-079

    • Research Watch
      KRAS Reprograms Glutamine Metabolism in Pancreatic Cancer
      Cancer Discov May 1 2013 3 (5) 483-483; DOI:10.1158/2159-8290.CD-RW2013-072

    • Research Watch
      The PP2A Subunit B55α Controls Adaption to Glutamine Deprivation
      Cancer Discov May 1 2013 3 (5) OF16-OF16; DOI:10.1158/2159-8290.CD-RW2013-062

  • Multiple Myeloma

    • Research Watch
      Multiple Myeloma Cells Require Caspase-10
      Cancer Discov May 1 2013 3 (5) 482-482; DOI:10.1158/2159-8290.CD-RW2013-076

  • Retinoblastoma

    • Research Watch
      MYCN Is Amplified in Retinoblastomas without RB1 Mutation
      Cancer Discov May 1 2013 3 (5) 479-479; DOI:10.1158/2159-8290.CD-RW2013-060

  • Sarcoma

    • Research Watch
      SS18–SSX Drives Synovial Sarcoma by Altering SWI/SNF Composition
      Cancer Discov May 1 2013 3 (5) 481-481; DOI:10.1158/2159-8290.CD-RW2013-070

  • Stem Cells

    • Research Watch
      Glioma Stem Cells Remodel the Perivascular Tumor Microenvironment
      Cancer Discov May 1 2013 3 (5) OF17-OF17; DOI:10.1158/2159-8290.CD-RW2013-073

  • Targeted Therapy

    • Research Watch
      Kinase Inhibitors Can Induce Chaperone Deprivation
      Cancer Discov May 1 2013 3 (5) 480-480; DOI:10.1158/2159-8290.CD-RW2013-066

  • Telomeres

    • Research Watch
      TERT Mutations Are Common in Cancers of Non–Self-Renewing Tissues
      Cancer Discov May 1 2013 3 (5) OF18-OF18; DOI:10.1158/2159-8290.CD-RW2013-068

  • Transcription

    • Research Watch
      MYC-Dependent Feedback Controls Androgen-Dependent Gene Expression
      Cancer Discov May 1 2013 3 (5) OF19-OF19; DOI:10.1158/2159-8290.CD-RW2013-069

  • Tumor Microenvironment

    • Research Watch
      Autocrine Glutamate Signaling Triggers Invasive Tumor Growth
      Cancer Discov May 1 2013 3 (5) OF20-OF20; DOI:10.1158/2159-8290.CD-RW2013-075

  • Tumorigenesis

    • Research Watch
      p53 Has Non–Cell-Autonomous Tumor Suppressor Activity
      Cancer Discov May 1 2013 3 (5) OF21-OF21; DOI:10.1158/2159-8290.CD-RW2013-078

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Cancer Discovery: 3 (5)
May 2013
Volume 3, Issue 5
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  • In This Issue
  • In the Spotlight
  • In Focus
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    • Biomarkers
    • Drug Resistance
    • Glioma
    • Immunotherapy
    • Leukemia
    • Melanoma
    • Metabolism
    • Multiple Myeloma
    • Retinoblastoma
    • Sarcoma
    • Stem Cells
    • Targeted Therapy
    • Telomeres
    • Transcription
    • Tumor Microenvironment
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