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Table of Contents

In This Issue

  • In This Issue
    In This Issue
    Cancer Discov May 1 2013 3 (5) 471-473; DOI:10.1158/2159-8290.CD-ITI13-05

In the Spotlight

In Focus

Review

Research Brief

  • Research Brief
    Histone H3.3 Mutations Drive Pediatric Glioblastoma through Upregulation of MYCN
    Lynn Bjerke, Alan Mackay, Meera Nandhabalan, Anna Burford, Alexa Jury, Sergey Popov, Dorine A. Bax, Diana Carvalho, Kathryn R. Taylor, Maria Vinci, Ilirjana Bajrami, Imelda M. McGonnell, Christopher J. Lord, Rui M. Reis, Darren Hargrave, Alan Ashworth, Paul Workman and Chris Jones
    Cancer Discov May 1 2013 3 (5) 512-519; DOI:10.1158/2159-8290.CD-12-0426

    Histone variant H3.3 glycine-34 mutations induce differential genome-wide histone H3 lysine 36 trimethylation and lead to upregulation of MYCN in the developing forebrain.

Research Articles

  • Research Articles | AuthorChoice
    Relief of Feedback Inhibition of HER3 Transcription by RAF and MEK Inhibitors Attenuates Their Antitumor Effects in BRAF-Mutant Thyroid Carcinomas
    Cristina Montero-Conde, Sergio Ruiz-Llorente, Jose M. Dominguez, Jeffrey A. Knauf, Agnes Viale, Eric J. Sherman, Mabel Ryder, Ronald A. Ghossein, Neal Rosen and James A. Fagin
    Cancer Discov May 1 2013 3 (5) 520-533; DOI:10.1158/2159-8290.CD-12-0531

    Lineage-specific HER3 upregulation and ligand-dependent HER2/HER3 activation confer resistance to MAPK pathway inhibitors in BRAF-mutant thyroid cancer cells.

  • Research Articles
    De-Repression of PDGFRβ Transcription Promotes Acquired Resistance to EGFR Tyrosine Kinase Inhibitors in Glioblastoma Patients
    David Akhavan, Alexandra L. Pourzia, Alex A. Nourian, Kevin J. Williams, David Nathanson, Ivan Babic, Genaro R. Villa, Kazuhiro Tanaka, Ali Nael, Huijun Yang, Julie Dang, Harry V. Vinters, William H. Yong, Mitchell Flagg, Fuyuhiko Tamanoi, Takashi Sasayama, C. David James, Harley I. Kornblum, Tim F. Cloughesy, Webster K. Cavenee, Steven J. Bensinger and Paul S. Mischel
    Cancer Discov May 1 2013 3 (5) 534-547; DOI:10.1158/2159-8290.CD-12-0502

    Transcriptional derepression of PDGFRβ in response to EGFR inhibition renders EGFR-mutant glioblastomas dependent on PDGFRβ for survival.

  • Research Articles
    TYK2–STAT1–BCL2 Pathway Dependence in T-cell Acute Lymphoblastic Leukemia
    Takaomi Sanda, Jeffrey W. Tyner, Alejandro Gutierrez, Vu N. Ngo, Jason Glover, Bill H. Chang, Arla Yost, Wenxue Ma, Angela G. Fleischman, Wenjun Zhou, Yandan Yang, Maria Kleppe, Yebin Ahn, Jessica Tatarek, Michelle A. Kelliher, Donna S. Neuberg, Ross L. Levine, Richard Moriggl, Mathias Müller, Nathanael S. Gray, Catriona H.M. Jamieson, Andrew P. Weng, Louis M. Staudt, Brian J. Druker and A. Thomas Look
    Cancer Discov May 1 2013 3 (5) 564-577; DOI:10.1158/2159-8290.CD-12-0504

    Activation of tyrosine kinase 2 (TYK2) by mutation or autocrine interleukin-10 signaling promotes T-ALL cell survival through activation of STAT1 and upregulation of BCL2.

  • Research Articles
    Bone Marrow–Derived Gr1+ Cells Can Generate a Metastasis-Resistant Microenvironment Via Induced Secretion of Thrombospondin-1
    Raúl Catena, Nandita Bhattacharya, Tina El Rayes, Suming Wang, Hyejin Choi, Dingcheng Gao, Seongho Ryu, Natasha Joshi, Diane Bielenberg, Sharrell B. Lee, Svein A. Haukaas, Karsten Gravdal, Ole J. Halvorsen, Lars A. Akslen, Randolph S. Watnick and Vivek Mittal
    Cancer Discov May 1 2013 3 (5) 578-589; DOI:10.1158/2159-8290.CD-12-0476

    Metastasis-incompetent tumors systemically reprogram bone marrow–derived myeloid cells in the premetastatic niche to produce TSP-1 to suppress metastatic outgrowth.

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Cancer Discovery: 3 (5)
May 2013
Volume 3, Issue 5

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