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MTOR Mutations in the Crosshairs of Targeted Therapy

Paul A. Rejto and Robert T. Abraham
Paul A. Rejto
Oncology Research Unit, Pfizer Worldwide Research and Development, San Diego, California
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Robert T. Abraham
Oncology Research Unit, Pfizer Worldwide Research and Development, San Diego, California
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DOI: 10.1158/2159-8290.CD-14-0332 Published May 2014
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Abstract

Summary: The identification of genetic lesions that affect tumor sensitivity to targeted therapies is a major objective of precision medicine. Two reports in this issue combine tumor genome analyses with functional characterization to uncover activating mutations in MTOR that confer sensitivity to a clinically used mTOR inhibitor. Cancer Discov; 4(5); 513–5. ©2014 AACR.

See related article by Wagle et al., p. 546

See related article by Grabiner et al., p. 554

  • ©2014 American Association for Cancer Research.
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Cancer Discovery: 4 (5)
May 2014
Volume 4, Issue 5
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MTOR Mutations in the Crosshairs of Targeted Therapy
Paul A. Rejto and Robert T. Abraham
Cancer Discov May 1 2014 (4) (5) 513-515; DOI: 10.1158/2159-8290.CD-14-0332

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MTOR Mutations in the Crosshairs of Targeted Therapy
Paul A. Rejto and Robert T. Abraham
Cancer Discov May 1 2014 (4) (5) 513-515; DOI: 10.1158/2159-8290.CD-14-0332
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Cancer Discovery
eISSN: 2159-8290
ISSN: 2159-8274

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