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Cancer Discovery
Cancer Discovery

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T-Cell and NK-Cell Infiltration into Solid Tumors: A Key Limiting Factor for Efficacious Cancer Immunotherapy

Ignacio Melero, Ana Rouzaut, Greg T. Motz and George Coukos
Ignacio Melero
Authors' Affiliations:Center for Applied Medical Research and Clinica Universidad de Navarra, Pamplona, Spain; Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, Pennsylvania; and Ludwig Cancer Research Center and Department of Oncology, CHUV, Lausanne, SwitzerlandAuthors' Affiliations:Center for Applied Medical Research and Clinica Universidad de Navarra, Pamplona, Spain; Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, Pennsylvania; and Ludwig Cancer Research Center and Department of Oncology, CHUV, Lausanne, Switzerland
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Ana Rouzaut
Authors' Affiliations:Center for Applied Medical Research and Clinica Universidad de Navarra, Pamplona, Spain; Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, Pennsylvania; and Ludwig Cancer Research Center and Department of Oncology, CHUV, Lausanne, Switzerland
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Greg T. Motz
Authors' Affiliations:Center for Applied Medical Research and Clinica Universidad de Navarra, Pamplona, Spain; Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, Pennsylvania; and Ludwig Cancer Research Center and Department of Oncology, CHUV, Lausanne, Switzerland
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George Coukos
Authors' Affiliations:Center for Applied Medical Research and Clinica Universidad de Navarra, Pamplona, Spain; Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, Pennsylvania; and Ludwig Cancer Research Center and Department of Oncology, CHUV, Lausanne, SwitzerlandAuthors' Affiliations:Center for Applied Medical Research and Clinica Universidad de Navarra, Pamplona, Spain; Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, Pennsylvania; and Ludwig Cancer Research Center and Department of Oncology, CHUV, Lausanne, SwitzerlandAuthors' Affiliations:Center for Applied Medical Research and Clinica Universidad de Navarra, Pamplona, Spain; Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, Pennsylvania; and Ludwig Cancer Research Center and Department of Oncology, CHUV, Lausanne, Switzerland
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DOI: 10.1158/2159-8290.CD-13-0985 Published May 2014
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Article Information

Volume 4, Issue 5, pp. 522-526

DOI 
https://doi.org/10.1158/2159-8290.CD-13-0985
PubMed 
24795012

Published By 
American Association for Cancer Research
Print ISSN 
2159-8274
Online ISSN 
2159-8290
History 
  • Published first May 1, 2014.

Copyright & Usage 
©2014 American Association for Cancer Research.

Author Information

  1. Ignacio Melero1,2,
  2. Ana Rouzaut1,
  3. Greg T. Motz3 and
  4. George Coukos3,4,5
  1. Authors' Affiliations:1Center for Applied Medical Research and 2Clinica Universidad de Navarra, Pamplona, Spain; 3Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, Pennsylvania; and 4Ludwig Cancer Research Center and 5Department of Oncology, CHUV, Lausanne, Switzerland
  1. Corresponding Authors:
    Ignacio Melero, Center for Applied Medical Research and Clinica Univerisidad de Navarra, Av. Pio XII, 55, 31008 Pamplona, Spain. Phone: 34-948194700; Fax: 34-948194717; E-mail: imelero{at}unav.es; and George Coukos, Rue du Bugnon 27, CH-1011, Lausanne, Switzerland. E-mail: george.coukos{at}chuv.ch
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Cancer Discovery: 4 (5)
May 2014
Volume 4, Issue 5
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T-Cell and NK-Cell Infiltration into Solid Tumors: A Key Limiting Factor for Efficacious Cancer Immunotherapy
Ignacio Melero, Ana Rouzaut, Greg T. Motz and George Coukos
Cancer Discov May 1 2014 (4) (5) 522-526; DOI: 10.1158/2159-8290.CD-13-0985

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T-Cell and NK-Cell Infiltration into Solid Tumors: A Key Limiting Factor for Efficacious Cancer Immunotherapy
Ignacio Melero, Ana Rouzaut, Greg T. Motz and George Coukos
Cancer Discov May 1 2014 (4) (5) 522-526; DOI: 10.1158/2159-8290.CD-13-0985
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  • Article
    • Abstract
    • Introduction
    • T-Cell Infiltration is Important for Overall Survival
    • Molecular Tricks Played by Tumors to Attract Protumor Leukocytes and Repress Effector T-Cell Responses
    • Blocking T-Cell Entrance and Functions in Cancer
    • How to Modify T-Cell Infiltration to Help Immunotherapy
    • Concluding Remarks
    • Disclosure of Potential Conflicts of Interest
    • Grant Support
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    • References
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