Research Articles
p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis
Elise Alspach, Kevin C. Flanagan, Xianmin Luo, Megan K. Ruhland, Hui Huang, Ermira Pazolli, Maureen J. Donlin, Timothy Marsh, David Piwnica-Worms, Joseph Monahan, Deborah V. Novack, Sandra S. McAllister and Sheila A. Stewart
Elise Alspach
Departments of 1Cell Biology and Physiology, 2Medicine, and 3Pathology and Immunology; 4BRIGHT Institute, Washington University School of Medicine; Departments of 5Biochemistry & Molecular Biology and 6Molecular Microbiology & Immunology, Saint Louis University School of Medicine; 7Confluence Life Sciences, Inc., St. Louis, Missouri; 8Hematology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston; 9Harvard Stem Cell Institute and Broad Institute of Harvard and MIT, Cambridge, Massachusetts; and 10Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas
Departments of 1Cell Biology and Physiology, 2Medicine, and 3Pathology and Immunology; 4BRIGHT Institute, Washington University School of Medicine; Departments of 5Biochemistry & Molecular Biology and 6Molecular Microbiology & Immunology, Saint Louis University School of Medicine; 7Confluence Life Sciences, Inc., St. Louis, Missouri; 8Hematology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston; 9Harvard Stem Cell Institute and Broad Institute of Harvard and MIT, Cambridge, Massachusetts; and 10Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas
Kevin C. Flanagan
Departments of 1Cell Biology and Physiology, 2Medicine, and 3Pathology and Immunology; 4BRIGHT Institute, Washington University School of Medicine; Departments of 5Biochemistry & Molecular Biology and 6Molecular Microbiology & Immunology, Saint Louis University School of Medicine; 7Confluence Life Sciences, Inc., St. Louis, Missouri; 8Hematology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston; 9Harvard Stem Cell Institute and Broad Institute of Harvard and MIT, Cambridge, Massachusetts; and 10Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas
Departments of 1Cell Biology and Physiology, 2Medicine, and 3Pathology and Immunology; 4BRIGHT Institute, Washington University School of Medicine; Departments of 5Biochemistry & Molecular Biology and 6Molecular Microbiology & Immunology, Saint Louis University School of Medicine; 7Confluence Life Sciences, Inc., St. Louis, Missouri; 8Hematology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston; 9Harvard Stem Cell Institute and Broad Institute of Harvard and MIT, Cambridge, Massachusetts; and 10Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas
Xianmin Luo
Departments of 1Cell Biology and Physiology, 2Medicine, and 3Pathology and Immunology; 4BRIGHT Institute, Washington University School of Medicine; Departments of 5Biochemistry & Molecular Biology and 6Molecular Microbiology & Immunology, Saint Louis University School of Medicine; 7Confluence Life Sciences, Inc., St. Louis, Missouri; 8Hematology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston; 9Harvard Stem Cell Institute and Broad Institute of Harvard and MIT, Cambridge, Massachusetts; and 10Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas
Departments of 1Cell Biology and Physiology, 2Medicine, and 3Pathology and Immunology; 4BRIGHT Institute, Washington University School of Medicine; Departments of 5Biochemistry & Molecular Biology and 6Molecular Microbiology & Immunology, Saint Louis University School of Medicine; 7Confluence Life Sciences, Inc., St. Louis, Missouri; 8Hematology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston; 9Harvard Stem Cell Institute and Broad Institute of Harvard and MIT, Cambridge, Massachusetts; and 10Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas
Megan K. Ruhland
Departments of 1Cell Biology and Physiology, 2Medicine, and 3Pathology and Immunology; 4BRIGHT Institute, Washington University School of Medicine; Departments of 5Biochemistry & Molecular Biology and 6Molecular Microbiology & Immunology, Saint Louis University School of Medicine; 7Confluence Life Sciences, Inc., St. Louis, Missouri; 8Hematology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston; 9Harvard Stem Cell Institute and Broad Institute of Harvard and MIT, Cambridge, Massachusetts; and 10Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas
Departments of 1Cell Biology and Physiology, 2Medicine, and 3Pathology and Immunology; 4BRIGHT Institute, Washington University School of Medicine; Departments of 5Biochemistry & Molecular Biology and 6Molecular Microbiology & Immunology, Saint Louis University School of Medicine; 7Confluence Life Sciences, Inc., St. Louis, Missouri; 8Hematology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston; 9Harvard Stem Cell Institute and Broad Institute of Harvard and MIT, Cambridge, Massachusetts; and 10Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas
Hui Huang
Departments of 1Cell Biology and Physiology, 2Medicine, and 3Pathology and Immunology; 4BRIGHT Institute, Washington University School of Medicine; Departments of 5Biochemistry & Molecular Biology and 6Molecular Microbiology & Immunology, Saint Louis University School of Medicine; 7Confluence Life Sciences, Inc., St. Louis, Missouri; 8Hematology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston; 9Harvard Stem Cell Institute and Broad Institute of Harvard and MIT, Cambridge, Massachusetts; and 10Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas
Departments of 1Cell Biology and Physiology, 2Medicine, and 3Pathology and Immunology; 4BRIGHT Institute, Washington University School of Medicine; Departments of 5Biochemistry & Molecular Biology and 6Molecular Microbiology & Immunology, Saint Louis University School of Medicine; 7Confluence Life Sciences, Inc., St. Louis, Missouri; 8Hematology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston; 9Harvard Stem Cell Institute and Broad Institute of Harvard and MIT, Cambridge, Massachusetts; and 10Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas
Ermira Pazolli
Departments of 1Cell Biology and Physiology, 2Medicine, and 3Pathology and Immunology; 4BRIGHT Institute, Washington University School of Medicine; Departments of 5Biochemistry & Molecular Biology and 6Molecular Microbiology & Immunology, Saint Louis University School of Medicine; 7Confluence Life Sciences, Inc., St. Louis, Missouri; 8Hematology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston; 9Harvard Stem Cell Institute and Broad Institute of Harvard and MIT, Cambridge, Massachusetts; and 10Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas
Maureen J. Donlin
Departments of 1Cell Biology and Physiology, 2Medicine, and 3Pathology and Immunology; 4BRIGHT Institute, Washington University School of Medicine; Departments of 5Biochemistry & Molecular Biology and 6Molecular Microbiology & Immunology, Saint Louis University School of Medicine; 7Confluence Life Sciences, Inc., St. Louis, Missouri; 8Hematology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston; 9Harvard Stem Cell Institute and Broad Institute of Harvard and MIT, Cambridge, Massachusetts; and 10Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas
Departments of 1Cell Biology and Physiology, 2Medicine, and 3Pathology and Immunology; 4BRIGHT Institute, Washington University School of Medicine; Departments of 5Biochemistry & Molecular Biology and 6Molecular Microbiology & Immunology, Saint Louis University School of Medicine; 7Confluence Life Sciences, Inc., St. Louis, Missouri; 8Hematology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston; 9Harvard Stem Cell Institute and Broad Institute of Harvard and MIT, Cambridge, Massachusetts; and 10Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas
Timothy Marsh
Departments of 1Cell Biology and Physiology, 2Medicine, and 3Pathology and Immunology; 4BRIGHT Institute, Washington University School of Medicine; Departments of 5Biochemistry & Molecular Biology and 6Molecular Microbiology & Immunology, Saint Louis University School of Medicine; 7Confluence Life Sciences, Inc., St. Louis, Missouri; 8Hematology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston; 9Harvard Stem Cell Institute and Broad Institute of Harvard and MIT, Cambridge, Massachusetts; and 10Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas
David Piwnica-Worms
Departments of 1Cell Biology and Physiology, 2Medicine, and 3Pathology and Immunology; 4BRIGHT Institute, Washington University School of Medicine; Departments of 5Biochemistry & Molecular Biology and 6Molecular Microbiology & Immunology, Saint Louis University School of Medicine; 7Confluence Life Sciences, Inc., St. Louis, Missouri; 8Hematology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston; 9Harvard Stem Cell Institute and Broad Institute of Harvard and MIT, Cambridge, Massachusetts; and 10Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas
Joseph Monahan
Departments of 1Cell Biology and Physiology, 2Medicine, and 3Pathology and Immunology; 4BRIGHT Institute, Washington University School of Medicine; Departments of 5Biochemistry & Molecular Biology and 6Molecular Microbiology & Immunology, Saint Louis University School of Medicine; 7Confluence Life Sciences, Inc., St. Louis, Missouri; 8Hematology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston; 9Harvard Stem Cell Institute and Broad Institute of Harvard and MIT, Cambridge, Massachusetts; and 10Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas
Deborah V. Novack
Departments of 1Cell Biology and Physiology, 2Medicine, and 3Pathology and Immunology; 4BRIGHT Institute, Washington University School of Medicine; Departments of 5Biochemistry & Molecular Biology and 6Molecular Microbiology & Immunology, Saint Louis University School of Medicine; 7Confluence Life Sciences, Inc., St. Louis, Missouri; 8Hematology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston; 9Harvard Stem Cell Institute and Broad Institute of Harvard and MIT, Cambridge, Massachusetts; and 10Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas
Departments of 1Cell Biology and Physiology, 2Medicine, and 3Pathology and Immunology; 4BRIGHT Institute, Washington University School of Medicine; Departments of 5Biochemistry & Molecular Biology and 6Molecular Microbiology & Immunology, Saint Louis University School of Medicine; 7Confluence Life Sciences, Inc., St. Louis, Missouri; 8Hematology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston; 9Harvard Stem Cell Institute and Broad Institute of Harvard and MIT, Cambridge, Massachusetts; and 10Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas
Sandra S. McAllister
Departments of 1Cell Biology and Physiology, 2Medicine, and 3Pathology and Immunology; 4BRIGHT Institute, Washington University School of Medicine; Departments of 5Biochemistry & Molecular Biology and 6Molecular Microbiology & Immunology, Saint Louis University School of Medicine; 7Confluence Life Sciences, Inc., St. Louis, Missouri; 8Hematology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston; 9Harvard Stem Cell Institute and Broad Institute of Harvard and MIT, Cambridge, Massachusetts; and 10Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas
Departments of 1Cell Biology and Physiology, 2Medicine, and 3Pathology and Immunology; 4BRIGHT Institute, Washington University School of Medicine; Departments of 5Biochemistry & Molecular Biology and 6Molecular Microbiology & Immunology, Saint Louis University School of Medicine; 7Confluence Life Sciences, Inc., St. Louis, Missouri; 8Hematology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston; 9Harvard Stem Cell Institute and Broad Institute of Harvard and MIT, Cambridge, Massachusetts; and 10Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas
Sheila A. Stewart
Departments of 1Cell Biology and Physiology, 2Medicine, and 3Pathology and Immunology; 4BRIGHT Institute, Washington University School of Medicine; Departments of 5Biochemistry & Molecular Biology and 6Molecular Microbiology & Immunology, Saint Louis University School of Medicine; 7Confluence Life Sciences, Inc., St. Louis, Missouri; 8Hematology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston; 9Harvard Stem Cell Institute and Broad Institute of Harvard and MIT, Cambridge, Massachusetts; and 10Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas
Departments of 1Cell Biology and Physiology, 2Medicine, and 3Pathology and Immunology; 4BRIGHT Institute, Washington University School of Medicine; Departments of 5Biochemistry & Molecular Biology and 6Molecular Microbiology & Immunology, Saint Louis University School of Medicine; 7Confluence Life Sciences, Inc., St. Louis, Missouri; 8Hematology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston; 9Harvard Stem Cell Institute and Broad Institute of Harvard and MIT, Cambridge, Massachusetts; and 10Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas
Departments of 1Cell Biology and Physiology, 2Medicine, and 3Pathology and Immunology; 4BRIGHT Institute, Washington University School of Medicine; Departments of 5Biochemistry & Molecular Biology and 6Molecular Microbiology & Immunology, Saint Louis University School of Medicine; 7Confluence Life Sciences, Inc., St. Louis, Missouri; 8Hematology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston; 9Harvard Stem Cell Institute and Broad Institute of Harvard and MIT, Cambridge, Massachusetts; and 10Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas
DOI: 10.1158/2159-8290.CD-13-0743 Published June 2014

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Volume 4, Issue 6, pp. 716-729
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History
- Received October 10, 2013
- Revision received March 19, 2014
- Accepted March 20, 2014
- Published first March 26, 2014.
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- Previous version (March 26, 2014 - 05:44).
- Previous version (May 14, 2014 - 10:15).
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©2014 American Association for Cancer Research.
Author Information
- Elise Alspach1,4,
- Kevin C. Flanagan1,4,
- Xianmin Luo1,4,
- Megan K. Ruhland1,4,
- Hui Huang1,4,
- Ermira Pazolli1,
- Maureen J. Donlin5,6,
- Timothy Marsh8,
- David Piwnica-Worms10,
- Joseph Monahan7,
- Deborah V. Novack2,3,
- Sandra S. McAllister8,9 and
- Sheila A. Stewart1,2,4
- Authors' Affiliations: Departments of 1Cell Biology and Physiology, 2Medicine, and 3Pathology and Immunology; 4BRIGHT Institute, Washington University School of Medicine; Departments of 5Biochemistry & Molecular Biology and 6Molecular Microbiology & Immunology, Saint Louis University School of Medicine; 7Confluence Life Sciences, Inc., St. Louis, Missouri; 8Hematology Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston; 9Harvard Stem Cell Institute and Broad Institute of Harvard and MIT, Cambridge, Massachusetts; and 10Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas
- Corresponding Author:
Sheila A. Stewart, Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8228, St. Louis, MO 63110. Phone: 314-362-7437; Fax: 314-362-7463; E-mail: sheila.stewart{at}wustl.edu
Current address for E. Pazolli: AstraZeneca Pharmaceuticals, Waltham, Massachusetts.
June 2014
Volume 4, Issue 6
Volume 4, Issue 6
p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis
Elise Alspach, Kevin C. Flanagan, Xianmin Luo, Megan K. Ruhland, Hui Huang, Ermira Pazolli, Maureen J. Donlin, Timothy Marsh, David Piwnica-Worms, Joseph Monahan, Deborah V. Novack, Sandra S. McAllister and Sheila A. Stewart
Cancer Discov June 1 2014 (4) (6) 716-729; DOI: 10.1158/2159-8290.CD-13-0743
p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis
Elise Alspach, Kevin C. Flanagan, Xianmin Luo, Megan K. Ruhland, Hui Huang, Ermira Pazolli, Maureen J. Donlin, Timothy Marsh, David Piwnica-Worms, Joseph Monahan, Deborah V. Novack, Sandra S. McAllister and Sheila A. Stewart
Cancer Discov June 1 2014 (4) (6) 716-729; DOI: 10.1158/2159-8290.CD-13-0743
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