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Cancer Discovery
Cancer Discovery

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Table of Contents

In This Issue

  • In This Issue
    In This Issue
    Cancer Discov July 1 2014 4 (7) 745-748; DOI:10.1158/2159-8290.CD-ITI14-07

In the Spotlight

  • In the Spotlight
    SPSB1 May Have MET Its Match during Breast Cancer Recurrence
    Yuanbo Qin and Sandra S. McAllister
    Cancer Discov July 1 2014 4 (7) 760-761; DOI:10.1158/2159-8290.CD-14-0505

  • In the Spotlight
    BluepRINT for Moderate-to-Low Penetrance Cancer Susceptibility Genes Needed: Breast Cancer and Beyond
    Joanne Ngeow and Charis Eng
    Cancer Discov July 1 2014 4 (7) 762-763; DOI:10.1158/2159-8290.CD-14-0498

  • In the Spotlight
    A Little pRB Can Lead to Big Problems
    Philip W. Hinds
    Cancer Discov July 1 2014 4 (7) 764-765; DOI:10.1158/2159-8290.CD-14-0518

Mini Review

  • Mini Review
    Targeting Mitochondrial Metabolism by Inhibiting Autophagy in BRAF-Driven Cancers
    Anne M. Strohecker and Eileen White
    Cancer Discov July 1 2014 4 (7) 766-772; DOI:10.1158/2159-8290.CD-14-0196

Research Briefs

  • Research Briefs | AuthorChoice
    Autophagy Inhibition Improves Chemosensitivity in BRAFV600E Brain Tumors
    Jean M. Mulcahy Levy, Joshua C. Thompson, Andrea M. Griesinger, Vladimir Amani, Andrew M. Donson, Diane K. Birks, Michael J. Morgan, David M. Mirsky, Michael H. Handler, Nicholas K. Foreman and Andrew Thorburn
    Cancer Discov July 1 2014 4 (7) 773-780; DOI:10.1158/2159-8290.CD-14-0049

    BRAFV600E-positive pediatric central nervous system tumor cells are autophagy-dependent and can be effectively targeted with combined chloroquine and vemurafenib therapy.

  • Research Briefs
    Obligate Progression Precedes Lung Adenocarcinoma Dissemination
    Deborah R. Caswell, Chen-Hua Chuang, Dian Yang, Shin-Heng Chiou, Shashank Cheemalavagu, Caroline Kim-Kiselak, Andrew Connolly and Monte M. Winslow
    Cancer Discov July 1 2014 4 (7) 781-789; DOI:10.1158/2159-8290.CD-13-0862

    Tumor-cell dissemination is a rate-limiting step in lung cancer metastasis that requires genetic alterations that can be facilitated by p53 loss and is characterized by downregulation of Nkx2-1.

Research Articles

  • Research Articles | AuthorChoice
    SPSB1 Promotes Breast Cancer Recurrence by Potentiating c-MET Signaling
    Yi Feng, Tien-Chi Pan, Dhruv K. Pant, Kristi R. Chakrabarti, James V. Alvarez, Jason R. Ruth and Lewis A. Chodosh
    Cancer Discov July 1 2014 4 (7) 790-803; DOI:10.1158/2159-8290.CD-13-0548

    Upregulation of SPSB1 enhances the survival of residual tumor cells and mediates tumor recurrence by activating c-MET signaling in aggressive breast cancer subtypes.

  • Research Articles
    Rare Mutations in RINT1 Predispose Carriers to Breast and Lynch Syndrome–Spectrum Cancers
    Daniel J. Park, Kayoko Tao, Florence Le Calvez-Kelm, Tu Nguyen-Dumont, Nivonirina Robinot, Fleur Hammet, Fabrice Odefrey, Helen Tsimiklis, Zhi L. Teo, Louise B. Thingholm, Erin L. Young, Catherine Voegele, Andrew Lonie, Bernard J. Pope, Terrell C. Roane, Russell Bell, Hao Hu, Shankaracharya, Chad D. Huff, Jonathan Ellis, Jun Li, Igor V. Makunin, Esther M. John, Irene L. Andrulis, Mary B. Terry, Mary Daly, Saundra S. Buys, Carrie Snyder, Henry T. Lynch, Peter Devilee, Graham G. Giles, John L. Hopper, Bing-Jian Feng, Fabienne Lesueur, Sean V. Tavtigian, Melissa C. Southey and David E. Goldgar
    Cancer Discov July 1 2014 4 (7) 804-815; DOI:10.1158/2159-8290.CD-14-0212

    Rare variants in RINT1 are associated with increased risk for breast cancer as well as a spectrum of cancers that are associated with DNA mismatch repair defects.

  • Research Articles
    A Melanoma Cell State Distinction Influences Sensitivity to MAPK Pathway Inhibitors
    David J. Konieczkowski, Cory M. Johannessen, Omar Abudayyeh, Jong Wook Kim, Zachary A. Cooper, Adriano Piris, Dennie T. Frederick, Michal Barzily-Rokni, Ravid Straussman, Rizwan Haq, David E. Fisher, Jill P. Mesirov, William C. Hahn, Keith T. Flaherty, Jennifer A. Wargo, Pablo Tamayo and Levi A. Garraway
    Cancer Discov July 1 2014 4 (7) 816-827; DOI:10.1158/2159-8290.CD-13-0424

    BRAF-mutant melanoma can be classified into two transcriptional cell states that are defined by MITF and NF-κB activity and are correlated with intrinsic resistance to MAPK inhibition.

  • Research Articles
    A High-Throughput Fluorimetric Assay for 2-Hydroxyglutarate Identifies Zaprinast as a Glutaminase Inhibitor
    Adnan Elhammali, Joseph E. Ippolito, Lynne Collins, Jan Crowley, Jayne Marasa and David Piwnica-Worms
    Cancer Discov July 1 2014 4 (7) 828-839; DOI:10.1158/2159-8290.CD-13-0572

    Zaprinast is an inhibitor of glutaminase that reduces levels of the oncometabolite 2-hydroxyglutarate and shows activity in IDH-mutant and glutamine-addicted cancer cells.

  • Research Articles
    Haploinsufficiency of an RB–E2F1–Condensin II Complex Leads to Aberrant Replication and Aneuploidy
    Courtney H. Coschi, Charles A. Ishak, David Gallo, Aren Marshall, Srikanth Talluri, Jianxin Wang, Matthew J. Cecchini, Alison L. Martens, Vanessa Percy, Ian Welch, Paul C. Boutros, Grant W. Brown and Frederick A. Dick
    Cancer Discov July 1 2014 4 (7) 840-853; DOI:10.1158/2159-8290.CD-14-0215

    Loss of one RB1 allele disrupts a pRB–E2F1–condensin II complex that regulates DNA replication and is sufficient to induce replication stress, chromosome structure defects, and aneuploidy.

News in Brief

  • News in Brief
    People
    Cancer Discov July 1 2014 4 (7) 750-750; DOI:10.1158/2159-8290.CD-NB2014-064

  • News in Brief
    UK Partnership Targets Lung Cancer
    Cancer Discov July 1 2014 4 (7) 750-750; DOI:10.1158/2159-8290.CD-NB2014-070

  • News in Brief
    Patient's T Cells Target Tumor Mutation
    Cancer Discov July 1 2014 4 (7) 751-751; DOI:10.1158/2159-8290.CD-NB2014-079

  • News in Brief
    Rules Proposed for Unregulated Tobacco
    Cancer Discov July 1 2014 4 (7) 751-752; DOI:10.1158/2159-8290.CD-NB2014-076

  • News in Brief
    NIH Clinical Center Open to Collaboration
    Cancer Discov July 1 2014 4 (7) 752-752; DOI:10.1158/2159-8290.CD-NB2014-065

  • News in Brief
    Ramucirumab Approved for Gastric Cancer
    Cancer Discov July 1 2014 4 (7) 752-753; DOI:10.1158/2159-8290.CD-NB2014-069

  • News in Brief
    EGFR Inhibitors May Induce Tumor Stemness
    Cancer Discov July 1 2014 4 (7) 753-753; DOI:10.1158/2159-8290.CD-NB2014-073

  • News in Brief
    Ceritinib Gains FDA Approval for Lung Cancer
    Cancer Discov July 1 2014 4 (7) 753-754; DOI:10.1158/2159-8290.CD-NB2014-074

  • News in Brief
    Gene Deletion Speeds Mutation Rate
    Cancer Discov July 1 2014 4 (7) 754-754; DOI:10.1158/2159-8290.CD-NB2014-068

  • News in Brief
    Noted
    Cancer Discov July 1 2014 4 (7) 754-754; DOI:10.1158/2159-8290.CD-NB2014-063

  • News in Brief
    NIH Program to Sequence 1,000 Exomes
    Cancer Discov July 1 2014 4 (7) OF1-OF1; DOI:10.1158/2159-8290.CD-NB2014-075

  • News in Brief
    New Guidelines for HER2+ Breast Cancer
    Cancer Discov July 1 2014 4 (7) OF2-OF2; DOI:10.1158/2159-8290.CD-NB2014-078

  • News in Brief
    Pharma Giants Swap Research Programs
    Cancer Discov July 1 2014 4 (7) OF3-OF3; DOI:10.1158/2159-8290.CD-NB2014-071

  • News in Brief
    Cancer Vaccine Shows Benefit in Solid Tumors
    Cancer Discov July 1 2014 4 (7) OF4-OF4; DOI:10.1158/2159-8290.CD-NB2014-072

  • News in Brief
    Enzalutamide Before Chemotherapy Prolongs Survival
    Cancer Discov July 1 2014 4 (7) OF5-OF5; DOI:10.1158/2159-8290.CD-NB2014-066

  • News in Brief
    Colorectal Cancer Rates on the Decline
    Cancer Discov July 1 2014 4 (7) OF6-OF6; DOI:10.1158/2159-8290.CD-NB2014-067

Research Watch

  • Cell Cycle

    • Research Watch
      PARK2 Coordinately Controls Cyclin D and Cyclin E
      Cancer Discov July 1 2014 4 (7) OF7-OF7; DOI:10.1158/2159-8290.CD-RW2014-108

  • DNA Damage

    • Research Watch
      STK4 Inhibition Promotes YAP1-Mediated Apoptosis in Hematologic Cancers
      Cancer Discov July 1 2014 4 (7) OF8-OF8; DOI:10.1158/2159-8290.CD-RW2014-112

  • Drug Resistance

    • Research Watch
      MET Inhibitor Efficacy Relies on Sustained Inhibition of STAT3 and ERK
      Cancer Discov July 1 2014 4 (7) OF9-OF9; DOI:10.1158/2159-8290.CD-RW2014-102

  • Epigenetics

    • Research Watch
      LncRNA-driven H4K20 Trimethylation Contributes to Quiescence
      Cancer Discov July 1 2014 4 (7) OF10-OF10; DOI:10.1158/2159-8290.CD-RW2014-101

  • Gastric Cancer

    • Research Watch
      Gastric Cancer Subtypes Are Characterized by Diverse Genomic Alterations
      Cancer Discov July 1 2014 4 (7) OF11-OF11; DOI:10.1158/2159-8290.CD-RW2014-113

  • Genomics

    • Research Watch
      Whole-Exome Sequencing of Archival Tissue Can Guide Personalized Medicine
      Cancer Discov July 1 2014 4 (7) 757-757; DOI:10.1158/2159-8290.CD-RW2014-118

  • Hepatocellular Carcinoma

    • Research Watch
      A Long Noncoding RNA Directs Invasion and Colonization in HCC
      Cancer Discov July 1 2014 4 (7) OF12-OF12; DOI:10.1158/2159-8290.CD-RW2014-100

  • Immune Evasion

    • Research Watch
      Cytotoxic T Lymphocyte Dysfunction Is Caused by Treg–APC Interactions
      Cancer Discov July 1 2014 4 (7) 755-755; DOI:10.1158/2159-8290.CD-RW2014-115

    • Research Watch
      Expression of FASL in the Tumor Endothelium Limits T-cell Infiltration
      Cancer Discov July 1 2014 4 (7) OF13-OF13; DOI:10.1158/2159-8290.CD-RW2014-106

  • Immunotherapy

    • Research Watch
      CD137 Activation Augments the Efficacy of EGFR-Targeted Therapy
      Cancer Discov July 1 2014 4 (7) 758-758; DOI:10.1158/2159-8290.CD-RW2014-120

  • Inflammation

    • Research Watch
      Tumor-Associated Macrophages Are Distinct from Normal Macrophages
      Cancer Discov July 1 2014 4 (7) 756-756; DOI:10.1158/2159-8290.CD-RW2014-111

  • Leukemia

    • Research Watch
      SYK Is a Therapeutic Target in B-ALL
      Cancer Discov July 1 2014 4 (7) 756-756; DOI:10.1158/2159-8290.CD-RW2014-119

    • Research Watch
      The IRE1–XBP1 Pathway Is a Therapeutic Target in CLL
      Cancer Discov July 1 2014 4 (7) OF14-OF14; DOI:10.1158/2159-8290.CD-RW2014-114

  • Lung Cancer

    • Research Watch
      Inactivation of Lkb1 and Pten in Mice Recapitulates Human Lung SCC
      Cancer Discov July 1 2014 4 (7) OF15-OF15; DOI:10.1158/2159-8290.CD-RW2014-105

  • Metabolism

    • Research Watch
      MYC-Driven Tumorigenesis Is Dependent on PRPS2
      Cancer Discov July 1 2014 4 (7) 757-757; DOI:10.1158/2159-8290.CD-RW2014-121

    • Research Watch
      FLCN Regulates Metabolic Reprogramming via AMPK Signaling to HIF1α
      Cancer Discov July 1 2014 4 (7) OF16-OF16; DOI:10.1158/2159-8290.CD-RW2014-103

  • Pancreatic Cancer

    • Research Watch
      UPF1 Is Recurrently Mutated in Pancreatic Adenosquamous Carcinoma
      Cancer Discov July 1 2014 4 (7) 759-759; DOI:10.1158/2159-8290.CD-RW2014-124

    • Research Watch
      KRAS-Dependent IL17 Signaling Promotes Pancreatic Neoplasia
      Cancer Discov July 1 2014 4 (7) OF17-OF17; DOI:10.1158/2159-8290.CD-RW2014-117

  • Prostate Cancer

    • Research Watch
      BET Bromodomain Proteins Are Therapeutic Targets in CRPC
      Cancer Discov July 1 2014 4 (7) OF18-OF18; DOI:10.1158/2159-8290.CD-RW2014-098

  • Rhabdomyosarcoma

    • Research Watch
      A MYOD1 Mutation Cooperates with PI3K Pathway Activation in ERMS
      Cancer Discov July 1 2014 4 (7) OF19-OF19; DOI:10.1158/2159-8290.CD-RW2014-109

  • Sarcoma

    • Research Watch
      Dystrophin Is a Tumor Suppressor in Myogenic Cancers
      Cancer Discov July 1 2014 4 (7) 755-755; DOI:10.1158/2159-8290.CD-RW2014-107

  • Signaling

    • Research Watch
      Methylation of MAP3K2 by SMYD3 Contributes to RAS-Driven Oncogenesis
      Cancer Discov July 1 2014 4 (7) 759-759; DOI:10.1158/2159-8290.CD-RW2014-122

  • Tumor Microenvironment

    • Research Watch
      Stromal Cells Inhibit Pancreatic Tumor Growth and Angiogenesis
      Cancer Discov July 1 2014 4 (7) 758-758; DOI:10.1158/2159-8290.CD-RW2014-125

    • Research Watch
      Fibroblast Depletion Accelerates PDAC Progression and Reduces Survival
      Cancer Discov July 1 2014 4 (7) OF20-OF20; DOI:10.1158/2159-8290.CD-RW2014-123

  • Tumor Suppressors

    • Research Watch
      Alternative Polyadenylation Promotes Glioblastoma Growth
      Cancer Discov July 1 2014 4 (7) OF21-OF21; DOI:10.1158/2159-8290.CD-RW2014-110

    • Research Watch
      The Role of PTEN Loss in Tumor Maintenance Is Context Dependent
      Cancer Discov July 1 2014 4 (7) OF22-OF22; DOI:10.1158/2159-8290.CD-RW2014-104

    • Research Watch
      PTEN Mutants Act as Dominant Negatives to Disrupt PTEN Activity
      Cancer Discov July 1 2014 4 (7) OF23-OF23; DOI:10.1158/2159-8290.CD-RW2014-099

  • Tumorigenesis

    • Research Watch
      Disruption of Thymic Cell Competition Drives T-ALL
      Cancer Discov July 1 2014 4 (7) OF24-OF24; DOI:10.1158/2159-8290.CD-RW2014-116

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Cancer Discovery: 4 (7)
July 2014
Volume 4, Issue 7
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  • In This Issue
  • In the Spotlight
  • Mini Review
  • Research Briefs
  • Research Articles
  • News in Brief
  • Research Watch
    • Cell Cycle
    • DNA Damage
    • Drug Resistance
    • Epigenetics
    • Gastric Cancer
    • Genomics
    • Hepatocellular Carcinoma
    • Immune Evasion
    • Immunotherapy
    • Inflammation
    • Leukemia
    • Lung Cancer
    • Metabolism
    • Pancreatic Cancer
    • Prostate Cancer
    • Rhabdomyosarcoma
    • Sarcoma
    • Signaling
    • Tumor Microenvironment
    • Tumor Suppressors
    • Tumorigenesis
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