In This Issue
Cancer Discov July 1 2014 4 (7) 745-748; DOI:10.1158/2159-8290.CD-ITI14-07
BRAFV600E-positive pediatric central nervous system tumor cells are autophagy-dependent and can be effectively targeted with combined chloroquine and vemurafenib therapy.
Tumor-cell dissemination is a rate-limiting step in lung cancer metastasis that requires genetic alterations that can be facilitated by p53 loss and is characterized by downregulation of Nkx2-1.
Upregulation of SPSB1 enhances the survival of residual tumor cells and mediates tumor recurrence by activating c-MET signaling in aggressive breast cancer subtypes.
Rare variants in RINT1 are associated with increased risk for breast cancer as well as a spectrum of cancers that are associated with DNA mismatch repair defects.
BRAF-mutant melanoma can be classified into two transcriptional cell states that are defined by MITF and NF-κB activity and are correlated with intrinsic resistance to MAPK inhibition.
Zaprinast is an inhibitor of glutaminase that reduces levels of the oncometabolite 2-hydroxyglutarate and shows activity in IDH-mutant and glutamine-addicted cancer cells.
Loss of one RB1 allele disrupts a pRB–E2F1–condensin II complex that regulates DNA replication and is sufficient to induce replication stress, chromosome structure defects, and aneuploidy.