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In This Issue

  • In This Issue
    In This Issue
    Cancer Discov July 1 2014 4 (7) 745-748; DOI:10.1158/2159-8290.CD-ITI14-07

In the Spotlight

Mini Review

Research Briefs

  • Research Briefs | AuthorChoice
    Autophagy Inhibition Improves Chemosensitivity in BRAFV600E Brain Tumors
    Jean M. Mulcahy Levy, Joshua C. Thompson, Andrea M. Griesinger, Vladimir Amani, Andrew M. Donson, Diane K. Birks, Michael J. Morgan, David M. Mirsky, Michael H. Handler, Nicholas K. Foreman and Andrew Thorburn
    Cancer Discov July 1 2014 4 (7) 773-780; DOI:10.1158/2159-8290.CD-14-0049

    BRAFV600E-positive pediatric central nervous system tumor cells are autophagy-dependent and can be effectively targeted with combined chloroquine and vemurafenib therapy.

  • Research Briefs
    Obligate Progression Precedes Lung Adenocarcinoma Dissemination
    Deborah R. Caswell, Chen-Hua Chuang, Dian Yang, Shin-Heng Chiou, Shashank Cheemalavagu, Caroline Kim-Kiselak, Andrew Connolly and Monte M. Winslow
    Cancer Discov July 1 2014 4 (7) 781-789; DOI:10.1158/2159-8290.CD-13-0862

    Tumor-cell dissemination is a rate-limiting step in lung cancer metastasis that requires genetic alterations that can be facilitated by p53 loss and is characterized by downregulation of Nkx2-1.

Research Articles

  • Research Articles | AuthorChoice
    SPSB1 Promotes Breast Cancer Recurrence by Potentiating c-MET Signaling
    Yi Feng, Tien-Chi Pan, Dhruv K. Pant, Kristi R. Chakrabarti, James V. Alvarez, Jason R. Ruth and Lewis A. Chodosh
    Cancer Discov July 1 2014 4 (7) 790-803; DOI:10.1158/2159-8290.CD-13-0548

    Upregulation of SPSB1 enhances the survival of residual tumor cells and mediates tumor recurrence by activating c-MET signaling in aggressive breast cancer subtypes.

  • Research Articles
    Rare Mutations in RINT1 Predispose Carriers to Breast and Lynch Syndrome–Spectrum Cancers
    Daniel J. Park, Kayoko Tao, Florence Le Calvez-Kelm, Tu Nguyen-Dumont, Nivonirina Robinot, Fleur Hammet, Fabrice Odefrey, Helen Tsimiklis, Zhi L. Teo, Louise B. Thingholm, Erin L. Young, Catherine Voegele, Andrew Lonie, Bernard J. Pope, Terrell C. Roane, Russell Bell, Hao Hu, Shankaracharya, Chad D. Huff, Jonathan Ellis, Jun Li, Igor V. Makunin, Esther M. John, Irene L. Andrulis, Mary B. Terry, Mary Daly, Saundra S. Buys, Carrie Snyder, Henry T. Lynch, Peter Devilee, Graham G. Giles, John L. Hopper, Bing-Jian Feng, Fabienne Lesueur, Sean V. Tavtigian, Melissa C. Southey and David E. Goldgar
    Cancer Discov July 1 2014 4 (7) 804-815; DOI:10.1158/2159-8290.CD-14-0212

    Rare variants in RINT1 are associated with increased risk for breast cancer as well as a spectrum of cancers that are associated with DNA mismatch repair defects.

  • Research Articles
    A Melanoma Cell State Distinction Influences Sensitivity to MAPK Pathway Inhibitors
    David J. Konieczkowski, Cory M. Johannessen, Omar Abudayyeh, Jong Wook Kim, Zachary A. Cooper, Adriano Piris, Dennie T. Frederick, Michal Barzily-Rokni, Ravid Straussman, Rizwan Haq, David E. Fisher, Jill P. Mesirov, William C. Hahn, Keith T. Flaherty, Jennifer A. Wargo, Pablo Tamayo and Levi A. Garraway
    Cancer Discov July 1 2014 4 (7) 816-827; DOI:10.1158/2159-8290.CD-13-0424

    BRAF-mutant melanoma can be classified into two transcriptional cell states that are defined by MITF and NF-κB activity and are correlated with intrinsic resistance to MAPK inhibition.

  • Research Articles
    Haploinsufficiency of an RB–E2F1–Condensin II Complex Leads to Aberrant Replication and Aneuploidy
    Courtney H. Coschi, Charles A. Ishak, David Gallo, Aren Marshall, Srikanth Talluri, Jianxin Wang, Matthew J. Cecchini, Alison L. Martens, Vanessa Percy, Ian Welch, Paul C. Boutros, Grant W. Brown and Frederick A. Dick
    Cancer Discov July 1 2014 4 (7) 840-853; DOI:10.1158/2159-8290.CD-14-0215

    Loss of one RB1 allele disrupts a pRB–E2F1–condensin II complex that regulates DNA replication and is sufficient to induce replication stress, chromosome structure defects, and aneuploidy.

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Cancer Discovery: 4 (7)
July 2014
Volume 4, Issue 7

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