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Cancer Discovery
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EGFR Variant Heterogeneity in Glioblastoma Resolved through Single-Nucleus Sequencing

Joshua M. Francis, Cheng-Zhong Zhang, Cecile L. Maire, Joonil Jung, Veronica E. Manzo, Viktor A. Adalsteinsson, Heather Homer, Sam Haidar, Brendan Blumenstiel, Chandra Sekhar Pedamallu, Azra H. Ligon, J. Christopher Love, Matthew Meyerson and Keith L. Ligon
Joshua M. Francis
1Broad Institute of Harvard and MIT, Cambridge, Massachusetts.
2Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Cheng-Zhong Zhang
1Broad Institute of Harvard and MIT, Cambridge, Massachusetts.
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Cecile L. Maire
2Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Joonil Jung
1Broad Institute of Harvard and MIT, Cambridge, Massachusetts.
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Veronica E. Manzo
2Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Viktor A. Adalsteinsson
1Broad Institute of Harvard and MIT, Cambridge, Massachusetts.
3Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.
4The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.
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Heather Homer
5Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Sam Haidar
2Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Brendan Blumenstiel
1Broad Institute of Harvard and MIT, Cambridge, Massachusetts.
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Chandra Sekhar Pedamallu
1Broad Institute of Harvard and MIT, Cambridge, Massachusetts.
2Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Azra H. Ligon
5Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts.
6Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.
7Department of Pathology, Boston Children's Hospital, Boston, Massachusetts.
8Department of Pathology, Harvard Medical School, Boston, Massachusetts.
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J. Christopher Love
1Broad Institute of Harvard and MIT, Cambridge, Massachusetts.
3Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.
4The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.
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Matthew Meyerson
1Broad Institute of Harvard and MIT, Cambridge, Massachusetts.
2Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
8Department of Pathology, Harvard Medical School, Boston, Massachusetts.
9Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts.
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  • For correspondence: Keith_Ligon@dfci.harvard.edu Matthew_Meyerson@dfci.harvard.edu
Keith L. Ligon
2Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
5Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts.
6Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.
7Department of Pathology, Boston Children's Hospital, Boston, Massachusetts.
8Department of Pathology, Harvard Medical School, Boston, Massachusetts.
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  • For correspondence: Keith_Ligon@dfci.harvard.edu Matthew_Meyerson@dfci.harvard.edu
DOI: 10.1158/2159-8290.CD-13-0879 Published August 2014
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Article Information

Volume 4, Issue 8, pp. 956-971

DOI 
https://doi.org/10.1158/2159-8290.CD-13-0879
PubMed 
24893890

Published By 
American Association for Cancer Research
Print ISSN 
2159-8274
Online ISSN 
2159-8290
History 
  • Received November 15, 2013
  • Revision received May 18, 2014
  • Accepted May 22, 2014
  • Published first June 3, 2014.

Article Versions

  • Previous version (June 3, 2014 - 06:46).
  • Previous version (June 5, 2014 - 07:30).
  • Previous version (July 18, 2014 - 08:13).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2014 American Association for Cancer Research.

Author Information

  1. Joshua M. Francis1,2,
  2. Cheng-Zhong Zhang1,
  3. Cecile L. Maire2,
  4. Joonil Jung1,
  5. Veronica E. Manzo2,
  6. Viktor A. Adalsteinsson1,3,4,
  7. Heather Homer5,
  8. Sam Haidar2,
  9. Brendan Blumenstiel1,
  10. Chandra Sekhar Pedamallu1,2,
  11. Azra H. Ligon5,6,7,8,
  12. J. Christopher Love1,3,4,
  13. Matthew Meyerson1,2,8,9,* and
  14. Keith L. Ligon2,5,6,7,8,*
  1. 1Broad Institute of Harvard and MIT, Cambridge, Massachusetts.
  2. 2Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  3. 3Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.
  4. 4The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.
  5. 5Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  6. 6Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.
  7. 7Department of Pathology, Boston Children's Hospital, Boston, Massachusetts.
  8. 8Department of Pathology, Harvard Medical School, Boston, Massachusetts.
  9. 9Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts.
  1. ↵*Corresponding Authors:
    Keith L. Ligon, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215. Phone: 617-632-2357; Fax: 617-582-8760; E-mail: Keith_Ligon{at}dfci.harvard.edu; and Mathew Meyerson, Matthew_Meyerson{at}dfci.harvard.edu
  1. J.M. Francis, C.-Z. Zhang, and C.L. Maire contributed equally to this article.

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Cancer Discovery: 4 (8)
August 2014
Volume 4, Issue 8
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EGFR Variant Heterogeneity in Glioblastoma Resolved through Single-Nucleus Sequencing
Joshua M. Francis, Cheng-Zhong Zhang, Cecile L. Maire, Joonil Jung, Veronica E. Manzo, Viktor A. Adalsteinsson, Heather Homer, Sam Haidar, Brendan Blumenstiel, Chandra Sekhar Pedamallu, Azra H. Ligon, J. Christopher Love, Matthew Meyerson and Keith L. Ligon
Cancer Discov August 1 2014 (4) (8) 956-971; DOI: 10.1158/2159-8290.CD-13-0879

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EGFR Variant Heterogeneity in Glioblastoma Resolved through Single-Nucleus Sequencing
Joshua M. Francis, Cheng-Zhong Zhang, Cecile L. Maire, Joonil Jung, Veronica E. Manzo, Viktor A. Adalsteinsson, Heather Homer, Sam Haidar, Brendan Blumenstiel, Chandra Sekhar Pedamallu, Azra H. Ligon, J. Christopher Love, Matthew Meyerson and Keith L. Ligon
Cancer Discov August 1 2014 (4) (8) 956-971; DOI: 10.1158/2159-8290.CD-13-0879
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