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Research Articles

Maturation Stage of T-cell Acute Lymphoblastic Leukemia Determines BCL-2 versus BCL-XL Dependence and Sensitivity to ABT-199

Triona Ni Chonghaile, Justine E. Roderick, Cian Glenfield, Jeremy Ryan, Stephen E. Sallan, Lewis B. Silverman, Mignon L. Loh, Stephen P. Hunger, Brent Wood, Daniel J. DeAngelo, Richard Stone, Marian Harris, Alejandro Gutierrez, Michelle A. Kelliher and Anthony Letai
Triona Ni Chonghaile
1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Justine E. Roderick
2Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts.
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Cian Glenfield
3Department of Genetics, The Smurfit Institute, Trinity College, Dublin, Ireland.
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Jeremy Ryan
1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Stephen E. Sallan
4Division of Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts.
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Lewis B. Silverman
4Division of Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts.
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Mignon L. Loh
5Department of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, San Francisco, California.
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Stephen P. Hunger
6Pediatric Hematology/Oncology/BMT, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, Colorado.
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Brent Wood
7Department of Medicine, University of Washington, Seattle, Washington.
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Daniel J. DeAngelo
1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Richard Stone
1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Marian Harris
8Department of Pathology, Boston Children's Hospital, Boston, Massachusetts.
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Alejandro Gutierrez
4Division of Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts.
9Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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Michelle A. Kelliher
2Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts.
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  • For correspondence: anthony_letai@dfci.harvard.edu michelle.kelliher@umassmed.edu
Anthony Letai
1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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  • For correspondence: anthony_letai@dfci.harvard.edu michelle.kelliher@umassmed.edu
DOI: 10.1158/2159-8290.CD-14-0353 Published September 2014
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Article Information

Volume 4, Issue 9, pp. 1074-1087

DOI 
https://doi.org/10.1158/2159-8290.CD-14-0353
PubMed 
24994123

Published By 
American Association for Cancer Research
Print ISSN 
2159-8274
Online ISSN 
2159-8290
History 
  • Received April 4, 2014
  • Revision received July 2, 2014
  • Accepted July 2, 2014
  • Published first July 3, 2014.

Article Versions

  • Previous version (July 3, 2014 - 06:43).
  • Previous version (August 11, 2014 - 08:07).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2014 American Association for Cancer Research.

Author Information

  1. Triona Ni Chonghaile1,
  2. Justine E. Roderick2,
  3. Cian Glenfield3,
  4. Jeremy Ryan1,
  5. Stephen E. Sallan4,
  6. Lewis B. Silverman4,
  7. Mignon L. Loh5,
  8. Stephen P. Hunger6,
  9. Brent Wood7,
  10. Daniel J. DeAngelo1,
  11. Richard Stone1,
  12. Marian Harris8,
  13. Alejandro Gutierrez4,9,
  14. Michelle A. Kelliher2,* and
  15. Anthony Letai1,*
  1. 1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  2. 2Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts.
  3. 3Department of Genetics, The Smurfit Institute, Trinity College, Dublin, Ireland.
  4. 4Division of Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts.
  5. 5Department of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, San Francisco, California.
  6. 6Pediatric Hematology/Oncology/BMT, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, Colorado.
  7. 7Department of Medicine, University of Washington, Seattle, Washington.
  8. 8Department of Pathology, Boston Children's Hospital, Boston, Massachusetts.
  9. 9Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  1. ↵*Corresponding Authors:
    Anthony Letai, Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215. Phone: 617-632-2348; Fax: 617-582-8160; E-mail: anthony_letai{at}dfci.harvard.edu; and Michelle A. Kelliher, Department of Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605. Phone: 508-856-8620; Fax: 508-856-1310; E-mail: michelle.kelliher{at}umassmed.edu
  • Current address for T. Ni Chonghaile: UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland.

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Cancer Discovery: 4 (9)
September 2014
Volume 4, Issue 9
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Maturation Stage of T-cell Acute Lymphoblastic Leukemia Determines BCL-2 versus BCL-XL Dependence and Sensitivity to ABT-199
Triona Ni Chonghaile, Justine E. Roderick, Cian Glenfield, Jeremy Ryan, Stephen E. Sallan, Lewis B. Silverman, Mignon L. Loh, Stephen P. Hunger, Brent Wood, Daniel J. DeAngelo, Richard Stone, Marian Harris, Alejandro Gutierrez, Michelle A. Kelliher and Anthony Letai
Cancer Discov September 1 2014 (4) (9) 1074-1087; DOI: 10.1158/2159-8290.CD-14-0353

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Maturation Stage of T-cell Acute Lymphoblastic Leukemia Determines BCL-2 versus BCL-XL Dependence and Sensitivity to ABT-199
Triona Ni Chonghaile, Justine E. Roderick, Cian Glenfield, Jeremy Ryan, Stephen E. Sallan, Lewis B. Silverman, Mignon L. Loh, Stephen P. Hunger, Brent Wood, Daniel J. DeAngelo, Richard Stone, Marian Harris, Alejandro Gutierrez, Michelle A. Kelliher and Anthony Letai
Cancer Discov September 1 2014 (4) (9) 1074-1087; DOI: 10.1158/2159-8290.CD-14-0353
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