RADical Response Puts an Exceptional Responder in CHKmate: A Synthetic Lethal Curative Response to DNA-Damaging Chemotherapy?

Guang Peng; Scott E. Woodman; Gordon B. Mills

doi:10.1158/2159-8290.CD-14-0738

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RADical Response Puts an Exceptional Responder in CHKmate: A Synthetic Lethal Curative Response to DNA-Damaging Chemotherapy?

Guang Peng, Scott E. Woodman and Gordon B. Mills

Guang Peng

1Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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For correspondence: gpeng@mdanderson.org

Scott E. Woodman

2Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

3Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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Gordon B. Mills

3Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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DOI: 10.1158/2159-8290.CD-14-0738 Published September 2014

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Figure 1.
The impaired function of the MRN complex due to a somatic mutation of RAD50 leads to a synthetic lethality in cancer cells when they are treated with CHK1 inhibitors and DNA-damaging chemotherapy irinotecan.

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September 2014
Volume 4, Issue 9

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RADical Response Puts an Exceptional Responder in CHKmate: A Synthetic Lethal Curative Response to DNA-Damaging Chemotherapy?