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Table of Contents

In This Issue

  • In This Issue
    In This Issue
    Cancer Discov November 1 2015 5 (11) 1111-1113; DOI:10.1158/2159-8290.CD-ITI5-11

In the Spotlight

In Focus

Review

Research Briefs

  • Research Briefs | AuthorChoice
    EGFR Kinase Domain Duplication (EGFR-KDD) Is a Novel Oncogenic Driver in Lung Cancer That Is Clinically Responsive to Afatinib
    Jean-Nicolas Gallant, Jonathan H. Sheehan, Timothy M. Shaver, Mark Bailey, Doron Lipson, Raghu Chandramohan, Monica Red Brewer, Sally J. York, Mark G. Kris, Jennifer A. Pietenpol, Marc Ladanyi, Vincent A. Miller, Siraj M. Ali, Jens Meiler and Christine M. Lovly
    Cancer Discov November 1 2015 5 (11) 1155-1163; DOI:10.1158/2159-8290.CD-15-0654

    Clinically observed in-frame tandem duplication of the EGFR kinase domain is a recurrent oncogenic driver alteration in NSCLC and confers sensitivity to EGFR inhibitors.

  • Research Briefs
    Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets
    Priscilla K. Brastianos, Scott L. Carter, Sandro Santagata, Daniel P. Cahill, Amaro Taylor-Weiner, Robert T. Jones, Eliezer M. Van Allen, Michael S. Lawrence, Peleg M. Horowitz, Kristian Cibulskis, Keith L. Ligon, Josep Tabernero, Joan Seoane, Elena Martinez-Saez, William T. Curry, Ian F. Dunn, Sun Ha Paek, Sung-Hye Park, Aaron McKenna, Aaron Chevalier, Mara Rosenberg, Frederick G. Barker II, Corey M. Gill, Paul Van Hummelen, Aaron R. Thorner, Bruce E. Johnson, Mai P. Hoang, Toni K. Choueiri, Sabina Signoretti, Carrie Sougnez, Michael S. Rabin, Nancy U. Lin, Eric P. Winer, Anat Stemmer-Rachamimov, Matthew Meyerson, Levi Garraway, Stacey Gabriel, Eric S. Lander, Rameen Beroukhim, Tracy T. Batchelor, José Baselga, David N. Louis, Gad Getz and William C. Hahn
    Cancer Discov November 1 2015 5 (11) 1164-1177; DOI:10.1158/2159-8290.CD-15-0369

    Sequencing of matched primary tumors and brain metastases reveals branched evolution and frequent oncogenic alterations in potentially targetable pathways.

Research Articles

  • Research Articles | AuthorChoice
    NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition
    Maria E.R. Garcia-Rendueles, Julio C. Ricarte-Filho, Brian R. Untch, Iňigo Landa, Jeffrey A. Knauf, Francesca Voza, Vicki E. Smith, Ian Ganly, Barry S. Taylor, Yogindra Persaud, Gisele Oler, Yuqiang Fang, Suresh C. Jhanwar, Agnes Viale, Adriana Heguy, Kety H. Huberman, Filippo Giancotti, Ronald Ghossein and James A. Fagin
    Cancer Discov November 1 2015 5 (11) 1178-1193; DOI:10.1158/2159-8290.CD-15-0330

    Loss of NF2 promotes thyroid tumorigenesis by increasing expression of both wild-type and mutant RAS in a YAP-dependent manner, resulting in enhanced dependency on MAPK signaling.

  • Research Articles
    PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex
    Pengda Liu, Wenjian Gan, Y. Rebecca Chin, Kohei Ogura, Jianping Guo, Jinfang Zhang, Bin Wang, John Blenis, Lewis C. Cantley, Alex Toker, Bing Su and Wenyi Wei
    Cancer Discov November 1 2015 5 (11) 1194-1209; DOI:10.1158/2159-8290.CD-15-0460

    Association of the SIN1 PH domain with the mTOR kinase domain suppresses mTORC2 kinase activity, which is relieved by PtdIns(3,4,5)P3 binding to SIN1 or by cancer patient–derived SIN1 PH domain mutations that prohibit mTOR binding.

  • Research Articles
    Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset
    Brinton Seashore-Ludlow, Matthew G. Rees, Jaime H. Cheah, Murat Cokol, Edmund V. Price, Matthew E. Coletti, Victor Jones, Nicole E. Bodycombe, Christian K. Soule, Joshua Gould, Benjamin Alexander, Ava Li, Philip Montgomery, Mathias J. Wawer, Nurdan Kuru, Joanne D. Kotz, C. Suk-Yee Hon, Benito Munoz, Ted Liefeld, Vlado Dančík, Joshua A. Bittker, Michelle Palmer, James E. Bradner, Alykhan F. Shamji, Paul A. Clemons and Stuart L. Schreiber
    Cancer Discov November 1 2015 5 (11) 1210-1223; DOI:10.1158/2159-8290.CD-15-0235

    Integration of small-molecule cancer cell line sensitivity profiles with known drug targets and genomic features reveals context-driven vulnerabilities and small-molecule mechanisms of action.

News in Brief

News in Depth

Research Watch

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Cancer Discovery: 5 (11)
November 2015
Volume 5, Issue 11

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