Skip to main content
  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

AACR logo

  • Register
  • Log in
  • My Cart
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Journal Sections
    • Subscriptions
    • Permissions and Reprints
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Collections
      • COVID-19 & Cancer Resource Center
      • Clinical Trials
      • Immuno-oncology
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citation
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
    • Journal Press Releases
  • COVID-19
  • Webinars
  • 10th Anniversary
  • Search More

    Advanced Search

  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in
  • My Cart

Search

  • Advanced search
Cancer Discovery
Cancer Discovery
  • Home
  • About
    • The Journal
    • AACR Journals
    • Journal Sections
    • Subscriptions
    • Permissions and Reprints
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Collections
      • COVID-19 & Cancer Resource Center
      • Clinical Trials
      • Immuno-oncology
      • Editors' Picks
      • "Best of" Collection
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citation
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
    • Journal Press Releases
  • COVID-19
  • Webinars
  • 10th Anniversary
  • Search More

    Advanced Search

Table of Contents

In This Issue

  • In This Issue
    In This Issue
    Cancer Discov November 1 2015 5 (11) 1111-1113; DOI:10.1158/2159-8290.CD-ITI5-11

In the Spotlight

  • In the Spotlight
    Drug-Resistant Brain Metastases: A Role for Pharmacology, Tumor Evolution, and Too-Late Therapy
    Thomas Stricker and Carlos L. Arteaga
    Cancer Discov November 1 2015 5 (11) 1124-1126; DOI:10.1158/2159-8290.CD-15-1166

  • In the Spotlight
    The SIN1-PH Domain Connects mTORC2 to PI3K
    Hai-Xin Yuan and Kun-Liang Guan
    Cancer Discov November 1 2015 5 (11) 1127-1129; DOI:10.1158/2159-8290.CD-15-1125

  • In the Spotlight
    Large-Scale Drug Screens Support Precision Medicine
    Joe W. Gray and Gordon B. Mills
    Cancer Discov November 1 2015 5 (11) 1130-1132; DOI:10.1158/2159-8290.CD-15-0945

In Focus

  • In Focus | AuthorChoice
    All the World's a Stage: Facilitating Discovery Science and Improved Cancer Care through the Global Alliance for Genomics and Health
    Mark Lawler, Lillian L. Siu, Heidi L. Rehm, Stephen J. Chanock, Gil Alterovitz, John Burn, Fabien Calvo, Denis Lacombe, Bin Tean Teh, Kathryn N. North and Charles L. Sawyers
    Cancer Discov November 1 2015 5 (11) 1133-1136; DOI:10.1158/2159-8290.CD-15-0821

Review

  • Reviews
    Homologous Recombination Deficiency: Exploiting the Fundamental Vulnerability of Ovarian Cancer
    Panagiotis A. Konstantinopoulos, Raphael Ceccaldi, Geoffrey I. Shapiro and Alan D. D'Andrea
    Cancer Discov November 1 2015 5 (11) 1137-1154; DOI:10.1158/2159-8290.CD-15-0714

Research Briefs

  • Research Briefs | AuthorChoice
    EGFR Kinase Domain Duplication (EGFR-KDD) Is a Novel Oncogenic Driver in Lung Cancer That Is Clinically Responsive to Afatinib
    Jean-Nicolas Gallant, Jonathan H. Sheehan, Timothy M. Shaver, Mark Bailey, Doron Lipson, Raghu Chandramohan, Monica Red Brewer, Sally J. York, Mark G. Kris, Jennifer A. Pietenpol, Marc Ladanyi, Vincent A. Miller, Siraj M. Ali, Jens Meiler and Christine M. Lovly
    Cancer Discov November 1 2015 5 (11) 1155-1163; DOI:10.1158/2159-8290.CD-15-0654

    Clinically observed in-frame tandem duplication of the EGFR kinase domain is a recurrent oncogenic driver alteration in NSCLC and confers sensitivity to EGFR inhibitors.

  • Research Briefs
    Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets
    Priscilla K. Brastianos, Scott L. Carter, Sandro Santagata, Daniel P. Cahill, Amaro Taylor-Weiner, Robert T. Jones, Eliezer M. Van Allen, Michael S. Lawrence, Peleg M. Horowitz, Kristian Cibulskis, Keith L. Ligon, Josep Tabernero, Joan Seoane, Elena Martinez-Saez, William T. Curry, Ian F. Dunn, Sun Ha Paek, Sung-Hye Park, Aaron McKenna, Aaron Chevalier, Mara Rosenberg, Frederick G. Barker II, Corey M. Gill, Paul Van Hummelen, Aaron R. Thorner, Bruce E. Johnson, Mai P. Hoang, Toni K. Choueiri, Sabina Signoretti, Carrie Sougnez, Michael S. Rabin, Nancy U. Lin, Eric P. Winer, Anat Stemmer-Rachamimov, Matthew Meyerson, Levi Garraway, Stacey Gabriel, Eric S. Lander, Rameen Beroukhim, Tracy T. Batchelor, José Baselga, David N. Louis, Gad Getz and William C. Hahn
    Cancer Discov November 1 2015 5 (11) 1164-1177; DOI:10.1158/2159-8290.CD-15-0369

    Sequencing of matched primary tumors and brain metastases reveals branched evolution and frequent oncogenic alterations in potentially targetable pathways.

Research Articles

  • Research Articles | AuthorChoice
    NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition
    Maria E.R. Garcia-Rendueles, Julio C. Ricarte-Filho, Brian R. Untch, Iňigo Landa, Jeffrey A. Knauf, Francesca Voza, Vicki E. Smith, Ian Ganly, Barry S. Taylor, Yogindra Persaud, Gisele Oler, Yuqiang Fang, Suresh C. Jhanwar, Agnes Viale, Adriana Heguy, Kety H. Huberman, Filippo Giancotti, Ronald Ghossein and James A. Fagin
    Cancer Discov November 1 2015 5 (11) 1178-1193; DOI:10.1158/2159-8290.CD-15-0330

    Loss of NF2 promotes thyroid tumorigenesis by increasing expression of both wild-type and mutant RAS in a YAP-dependent manner, resulting in enhanced dependency on MAPK signaling.

  • Research Articles
    PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex
    Pengda Liu, Wenjian Gan, Y. Rebecca Chin, Kohei Ogura, Jianping Guo, Jinfang Zhang, Bin Wang, John Blenis, Lewis C. Cantley, Alex Toker, Bing Su and Wenyi Wei
    Cancer Discov November 1 2015 5 (11) 1194-1209; DOI:10.1158/2159-8290.CD-15-0460

    Association of the SIN1 PH domain with the mTOR kinase domain suppresses mTORC2 kinase activity, which is relieved by PtdIns(3,4,5)P3 binding to SIN1 or by cancer patient–derived SIN1 PH domain mutations that prohibit mTOR binding.

  • Research Articles
    Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset
    Brinton Seashore-Ludlow, Matthew G. Rees, Jaime H. Cheah, Murat Cokol, Edmund V. Price, Matthew E. Coletti, Victor Jones, Nicole E. Bodycombe, Christian K. Soule, Joshua Gould, Benjamin Alexander, Ava Li, Philip Montgomery, Mathias J. Wawer, Nurdan Kuru, Joanne D. Kotz, C. Suk-Yee Hon, Benito Munoz, Ted Liefeld, Vlado Dančík, Joshua A. Bittker, Michelle Palmer, James E. Bradner, Alykhan F. Shamji, Paul A. Clemons and Stuart L. Schreiber
    Cancer Discov November 1 2015 5 (11) 1210-1223; DOI:10.1158/2159-8290.CD-15-0235

    Integration of small-molecule cancer cell line sensitivity profiles with known drug targets and genomic features reveals context-driven vulnerabilities and small-molecule mechanisms of action.

News in Brief

  • News in Brief
    People
    Cancer Discov November 1 2015 5 (11) 1114-1114; DOI:10.1158/2159-8290.CD-NB2015-126

  • News in Brief
    Precision Medicine for Pediatric Cancer
    Cancer Discov November 1 2015 5 (11) 1114-1114; DOI:10.1158/2159-8290.CD-NB2015-132

  • News in Brief
    Researchers Win Coveted Lasker Awards
    Cancer Discov November 1 2015 5 (11) 1114-1115; DOI:10.1158/2159-8290.CD-NB2015-138

  • News in Brief
    High-Affinity PD-1 Protein Has Potential
    Cancer Discov November 1 2015 5 (11) 1115-1116; DOI:10.1158/2159-8290.CD-NB2015-135

  • News in Brief
    A Vulnerable Side to MYC-Driven Cancers
    Cancer Discov November 1 2015 5 (11) 1116-1116; DOI:10.1158/2159-8290.CD-NB2015-129

  • News in Brief
    Implantable Devices Could Monitor Tumors Without MRI
    Cancer Discov November 1 2015 5 (11) 1116-1117; DOI:10.1158/2159-8290.CD-NB2015-128

  • News in Brief
    Melanoma Drug Works in Other Tumors
    Cancer Discov November 1 2015 5 (11) 1117-1117; DOI:10.1158/2159-8290.CD-NB2015-131

  • News in Brief
    Noted
    Cancer Discov November 1 2015 5 (11) 1117-1117; DOI:10.1158/2159-8290.CD-NB2015-125

  • News in Brief
    Desmoplastic Melanoma Carries High Mutation Burden
    Cancer Discov November 1 2015 5 (11) OF1-OF1; DOI:10.1158/2159-8290.CD-NB2015-134

  • News in Brief
    p53 Mutants Access Epigenetic Pathways to Promote Tumor Growth
    Cancer Discov November 1 2015 5 (11) OF2-OF2; DOI:10.1158/2159-8290.CD-NB2015-133

  • News in Brief
    MRI Scanners Guide Therapy to Tumors
    Cancer Discov November 1 2015 5 (11) OF3-OF3; DOI:10.1158/2159-8290.CD-NB2015-130

  • News in Brief
    Study Probes Burkitt Lymphoma–Malaria Link
    Cancer Discov November 1 2015 5 (11) OF4-OF4; DOI:10.1158/2159-8290.CD-NB2015-127

News in Depth

  • News in Depth
    Shelved 4-1BB Antibodies Make Comeback
    Cancer Discov November 1 2015 5 (11) 1118-1118; DOI:10.1158/2159-8290.CD-ND2015-003

Research Watch

  • Breast Cancer

    • Research Watch
      Plasma ctDNA Analysis Identifies Relapse Risk in Early Breast Cancer
      Cancer Discov November 1 2015 5 (11) OF5-OF5; DOI:10.1158/2159-8290.CD-RW2015-169

  • Clinical Trials

    • Research Watch
      Nivolumab Demonstrates Efficacy in Platinum-Resistant Ovarian Cancer
      Cancer Discov November 1 2015 5 (11) OF6-OF6; DOI:10.1158/2159-8290.CD-RW2015-180

    • Research Watch
      Vemurafenib Shows Activity in Hairy-Cell Leukemia
      Cancer Discov November 1 2015 5 (11) OF7-OF7; DOI:10.1158/2159-8290.CD-RW2015-177

    • Research Watch
      Daratumumab Monotherapy Is Effective in Multiple Myeloma
      Cancer Discov November 1 2015 5 (11) OF8-OF8; DOI:10.1158/2159-8290.CD-RW2015-171

    • Research Watch
      The MAPK Pathway Is a Therapeutic Target in BRAF-Mutant Colorectal Cancer
      Cancer Discov November 1 2015 5 (11) 1122-1122; DOI:10.1158/2159-8290.CD-RW2015-187

  • DNA Repair

    • Research Watch
      ATR and DNA-PK/CHK1 Elicit Distinct Responses in Cancer Cells
      Cancer Discov November 1 2015 5 (11) 1123-1123; DOI:10.1158/2159-8290.CD-RW2015-184

  • Drug Resistance

    • Research Watch
      Transcriptional Reprogramming Underlies BET Inhibitor Resistance
      Cancer Discov November 1 2015 5 (11) 1120-1120; DOI:10.1158/2159-8290.CD-RW2015-179

    • Research Watch
      Single-Cell Analysis of Prostate CTCs Highlights Resistance Mechanisms
      Cancer Discov November 1 2015 5 (11) 1122-1122; DOI:10.1158/2159-8290.CD-RW2015-182

  • Epigenetics

    • Research Watch
      Combination Therapy with the Epigenetic Drugs JQ1 and SAHA Inhibits PDAC
      Cancer Discov November 1 2015 5 (11) 1119-1119; DOI:10.1158/2159-8290.CD-RW2015-186

    • Research Watch
      A Broad H3K4me3 Signature Enriches for Tumor-Suppressor Genes
      Cancer Discov November 1 2015 5 (11) OF9-OF9; DOI:10.1158/2159-8290.CD-RW2015-166

  • Immune Evasion

    • Research Watch
      Cyclooxgenase Activity Enhances Immune Evasion to Drive Tumor Growth
      Cancer Discov November 1 2015 5 (11) OF10-OF10; DOI:10.1158/2159-8290.CD-RW2015-174

  • Immunology

    • Research Watch
      The Antitumor Activity of CD47 Blockade Depends on T-cell Activation
      Cancer Discov November 1 2015 5 (11) OF11-OF11; DOI:10.1158/2159-8290.CD-RW2015-172

  • Immunotherapy

    • Research Watch
      Inhibition of Melanoma Cell–Expressed PD-1 Reduces Tumor Growth
      Cancer Discov November 1 2015 5 (11) 1119-1119; DOI:10.1158/2159-8290.CD-RW2015-181

  • Leukemia

    • Research Watch
      Glutaminase Inhibition Synergizes with NOTCH1 Inhibition in T-ALL
      Cancer Discov November 1 2015 5 (11) 1123-1123; DOI:10.1158/2159-8290.CD-RW2015-183

    • Research Watch
      Retinoids Sensitize IKZF1-Mutant BCR–ABL1+ ALL Cells to Dasatinib
      Cancer Discov November 1 2015 5 (11) 1121-1121; DOI:10.1158/2159-8290.CD-RW2015-178

    • Research Watch
      PPARγ Agonists Deplete the Chronic Myeloid Leukemia Stem Cell Pool
      Cancer Discov November 1 2015 5 (11) 1120-1120; DOI:10.1158/2159-8290.CD-RW2015-173

  • Lung Cancer

    • Research Watch
      Up-front ALK/MEK Polytherapy Improves Therapeutic Responses
      Cancer Discov November 1 2015 5 (11) OF12-OF12; DOI:10.1158/2159-8290.CD-RW2015-165

  • Metabolism

    • Research Watch
      Tumor Glucose Consumption Inhibits T-cell Function
      Cancer Discov November 1 2015 5 (11) 1121-1121; DOI:10.1158/2159-8290.CD-RW2015-170

    • Research Watch
      Pyruvate Carboxylase Drives Tumorigenesis of SDH-Deficient Cells
      Cancer Discov November 1 2015 5 (11) OF13-OF13; DOI:10.1158/2159-8290.CD-RW2015-168

  • Oncogenes

    • Research Watch
      The Oncogene RAB35 Regulates PI3K–AKT Signaling
      Cancer Discov November 1 2015 5 (11) OF14-OF14; DOI:10.1158/2159-8290.CD-RW2015-176

  • Prostate Cancer

    • Research Watch
      SPOP-Driven ERG Proteolysis Suppresses Prostate Tumorigenesis
      Cancer Discov November 1 2015 5 (11) OF15-OF15; DOI:10.1158/2159-8290.CD-RW2015-175

  • Senescence

    • Research Watch
      The MacroH2A1–ATM Axis Regulates OIS-Driven Senescence Signaling
      Cancer Discov November 1 2015 5 (11) OF16-OF16; DOI:10.1158/2159-8290.CD-RW2015-167

  • Signaling

    • Research Watch
      ETS and Noncanonical NFκB Signaling Drive Reactivation of C250T-Mutant TERT
      Cancer Discov November 1 2015 5 (11) OF17-OF17; DOI:10.1158/2159-8290.CD-RW2015-185

Back to top
PreviousNext
Cancer Discovery: 5 (11)
November 2015
Volume 5, Issue 11
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover

Sign up for alerts

Jump to

  • In This Issue
  • In the Spotlight
  • In Focus
  • Review
  • Research Briefs
  • Research Articles
  • News in Brief
  • News in Depth
  • Research Watch
    • Breast Cancer
    • Clinical Trials
    • DNA Repair
    • Drug Resistance
    • Epigenetics
    • Immune Evasion
    • Immunology
    • Immunotherapy
    • Leukemia
    • Lung Cancer
    • Metabolism
    • Oncogenes
    • Prostate Cancer
    • Senescence
    • Signaling
Advertisement
  • Most Cited
  • Most Read
Loading
  • The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data
  • Macrophages Regulate Response to Chemotherapy
  • Core Resistance Mechanisms and Genetic Evolution of Melanoma under BRAF Inhibitor Selection
  • EGFR Mediates RAF Inhibitor Resistance in BRAF-Mutant Colorectal Cancer
  • PDX Models in Cancer Research
More...
  • Home
  • Alerts
  • Feedback
  • Privacy Policy
Facebook   Twitter   LinkedIn   YouTube   RSS

Articles

  • OnlineFirst
  • Current Issue
  • Past Issues

Info For

  • Authors
  • Subscribers
  • Advertisers
  • Librarians

About Cancer Discovery

  • About the Journal
  • Editors
  • Journal Sections
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2021 by the American Association for Cancer Research.

Cancer Discovery
eISSN: 2159-8290
ISSN: 2159-8274

Advertisement