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Cancer Discovery
Cancer Discovery
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Table of Contents

In This Issue

  • In This Issue
    In This Issue
    Cancer Discov December 1 2015 5 (12) 1225-1227; DOI:10.1158/2159-8290.CD-ITI5-12

In the Spotlight

  • In the Spotlight
    Overcoming Antigen Escape with CAR T-cell Therapy
    Hollie J. Jackson and Renier J. Brentjens
    Cancer Discov December 1 2015 5 (12) 1238-1240; DOI:10.1158/2159-8290.CD-15-1275

  • In the Spotlight
    RNF2 E3 or Not to E3: Dual Roles of RNF2 Overexpression in Melanoma
    Joshua C. Black and Johnathan R. Whetstine
    Cancer Discov December 1 2015 5 (12) 1241-1243; DOI:10.1158/2159-8290.CD-15-1285

  • In the Spotlight
    Infection and the Perils of B-cell Activation
    Mel Greaves and Markus Müschen
    Cancer Discov December 1 2015 5 (12) 1244-1246; DOI:10.1158/2159-8290.CD-15-1243

Review

  • Review
    Pancreatic Cancer Metabolism: Breaking It Down to Build It Back Up
    Rushika M. Perera and Nabeel Bardeesy
    Cancer Discov December 1 2015 5 (12) 1247-1261; DOI:10.1158/2159-8290.CD-15-0671

Research Briefs

  • Research Briefs
    RICTOR Amplification Defines a Novel Subset of Patients with Lung Cancer Who May Benefit from Treatment with mTORC1/2 Inhibitors
    Haiying Cheng, Yiyu Zou, Jeffrey S. Ross, Kai Wang, Xuewen Liu, Balazs Halmos, Siraj M. Ali, Huijie Liu, Amit Verma, Cristina Montagna, Abraham Chachoua, Sanjay Goel, Edward L. Schwartz, Changcheng Zhu, Jidong Shan, Yiting Yu, Kira Gritsman, Roman Yelensky, Doron Lipson, Geoff Otto, Matthew Hawryluk, Philip J. Stephens, Vincent A. Miller, Bilal Piperdi and Roman Perez-Soler
    Cancer Discov December 1 2015 5 (12) 1262-1270; DOI:10.1158/2159-8290.CD-14-0971

    Amplification of RICTOR is present in 8–13% of patients with lung cancer and is associated with a greater response to mTORC1/2 inhibition.

  • Research Briefs | AuthorChoice
    Molecular Heterogeneity and Receptor Coamplification Drive Resistance to Targeted Therapy in MET-Amplified Esophagogastric Cancer
    Eunice L. Kwak, Leanne G. Ahronian, Giulia Siravegna, Benedetta Mussolin, Darrell R. Borger, Jason T. Godfrey, Nicholas A. Jessop, Jeffrey W. Clark, Lawrence S. Blaszkowsky, David P. Ryan, Jochen K. Lennerz, A. John Iafrate, Alberto Bardelli, Theodore S. Hong and Ryan B. Corcoran
    Cancer Discov December 1 2015 5 (12) 1271-1281; DOI:10.1158/2159-8290.CD-15-0748

    Resistance to MET inhibition in MET-amplified esophagogastric cancer is mediated by KRAS mutation, coamplification of HER2 and/or EGFR, and intratumor heterogeneity in MET amplification.

Research Articles

  • Research Articles | AuthorChoice
    Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy
    Elena Sotillo, David M. Barrett, Kathryn L. Black, Asen Bagashev, Derek Oldridge, Glendon Wu, Robyn Sussman, Claudia Lanauze, Marco Ruella, Matthew R. Gazzara, Nicole M. Martinez, Colleen T. Harrington, Elaine Y. Chung, Jessica Perazzelli, Ted J. Hofmann, Shannon L. Maude, Pichai Raman, Alejandro Barrera, Saar Gill, Simon F. Lacey, Jan J. Melenhorst, David Allman, Elad Jacoby, Terry Fry, Crystal Mackall, Yoseph Barash, Kristen W. Lynch, John M. Maris, Stephan A. Grupp and Andrei Thomas-Tikhonenko
    Cancer Discov December 1 2015 5 (12) 1282-1295; DOI:10.1158/2159-8290.CD-15-1020

    Alternative splicing of CD19 prevents its recognition by CD19-targeted chimeric antigen receptor (CAR) T cells and can underlie resistance to CD19 CAR T-cell therapy in patients with B-ALL.

  • Research Articles | AuthorChoice
    A Cross-Species Analysis in Pancreatic Neuroendocrine Tumors Reveals Molecular Subtypes with Distinctive Clinical, Metastatic, Developmental, and Metabolic Characteristics
    Anguraj Sadanandam, Stephan Wullschleger, Costas A. Lyssiotis, Carsten Grötzinger, Stefano Barbi, Samantha Bersani, Jan Körner, Ismael Wafy, Andrea Mafficini, Rita T. Lawlor, Michele Simbolo, John M. Asara, Hendrik Bläker, Lewis C. Cantley, Bertram Wiedenmann, Aldo Scarpa and Douglas Hanahan
    Cancer Discov December 1 2015 5 (12) 1296-1313; DOI:10.1158/2159-8290.CD-15-0068

    Integrated mRNA and miRNA profiling of mouse and human pancreatic neuroendocrine tumors (PanNET) identifies distinct subtypes and validates the RIP1-Tag2 mouse model as representative of human PanNET.

  • Research Articles
    Dual Roles of RNF2 in Melanoma Progression
    Kunal Rai, Kadir C. Akdemir, Lawrence N. Kwong, Petko Fiziev, Chang-Jiun Wu, Emily Z. Keung, Sneha Sharma, Neha S. Samant, Maura Williams, Jacob B. Axelrad, Amiksha Shah, Dong Yang, Elizabeth A. Grimm, Michelle C. Barton, Denai R. Milton, Timothy P. Heffernan, James W. Horner, Suhendan Ekmekcioglu, Alexander J. Lazar, Jason Ernst and Lynda Chin
    Cancer Discov December 1 2015 5 (12) 1314-1327; DOI:10.1158/2159-8290.CD-15-0493

    The prometastatic and oncogenic functions of RNF2 in melanoma are driven by differential changes in gene expression regulated by chromatin modification or recruitment of transcriptional activators, respectively.

  • Research Articles | AuthorChoice
    Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of Pax5-Inherited Susceptibility
    Alberto Martín-Lorenzo, Julia Hauer, Carolina Vicente-Dueñas, Franziska Auer, Inés González-Herrero, Idoia García-Ramírez, Sebastian Ginzel, Ralf Thiele, Stefan N. Constantinescu, Christoph Bartenhagen, Martin Dugas, Michael Gombert, Daniel Schäfer, Oscar Blanco, Andrea Mayado, Alberto Orfao, Diego Alonso-López, Javier De Las Rivas, César Cobaleda, Maria Begoña García-Cenador, Francisco Javier García-Criado, Isidro Sánchez-García and Arndt Borkhardt
    Cancer Discov December 1 2015 5 (12) 1328-1343; DOI:10.1158/2159-8290.CD-15-0892

    Delayed exposure to infection promotes B-cell precursor acute lymphoblastic leukemia in the context of inactivating germline Pax5 mutations, which create an aberrant progenitor cell compartment that is susceptible to Jak3 mutation–induced transformation.

News in Brief

  • News in Brief
    People
    Cancer Discov December 1 2015 5 (12) 1228-1228; DOI:10.1158/2159-8290.CD-NB2015-140

  • News in Brief
    First Immunotherapy Combo Approved for Cancer
    Cancer Discov December 1 2015 5 (12) 1228-1228; DOI:10.1158/2159-8290.CD-NB2015-145

  • News in Brief
    HPV Vaccine Triggers Regression of Precancers
    Cancer Discov December 1 2015 5 (12) 1228-1229; DOI:10.1158/2159-8290.CD-NB2015-143

  • News in Brief
    Illuminating Cancer Resistance in Elephants
    Cancer Discov December 1 2015 5 (12) 1229-1229; DOI:10.1158/2159-8290.CD-NB2015-147

  • News in Brief
    Advancing the Precision Medicine Initiative
    Cancer Discov December 1 2015 5 (12) 1230-1230; DOI:10.1158/2159-8290.CD-NB2015-146

  • News in Brief
    Nobel Recognizes Seminal Work in DNA Repair
    Cancer Discov December 1 2015 5 (12) 1230-1231; DOI:10.1158/2159-8290.CD-NB2015-151

  • News in Brief
    Ruxolitinib Benefits Some with Pancreatic Cancer
    Cancer Discov December 1 2015 5 (12) 1231-1231; DOI:10.1158/2159-8290.CD-NB2015-142

  • News in Brief
    Noted
    Cancer Discov December 1 2015 5 (12) 1231-1231; DOI:10.1158/2159-8290.CD-NB2015-139

  • News in Brief
    Tweaking Transcription to Stop AML Cell Growth
    Cancer Discov December 1 2015 5 (12) OF1-OF1; DOI:10.1158/2159-8290.CD-NB2015-149

  • News in Brief
    More Benefits for Checkpoint Inhibitors in NSCLC
    Cancer Discov December 1 2015 5 (12) OF2-OF2; DOI:10.1158/2159-8290.CD-NB2015-148

  • News in Brief
    Four New SPORE Grants Awarded
    Cancer Discov December 1 2015 5 (12) OF3-OF3; DOI:10.1158/2159-8290.CD-NB2015-137

  • News in Brief
    ADC Shows Effectiveness in SCLC
    Cancer Discov December 1 2015 5 (12) OF4-OF4; DOI:10.1158/2159-8290.CD-NB2015-144

  • News in Brief
    Open-Source Approach May Speed Drug Discovery
    Cancer Discov December 1 2015 5 (12) OF5-OF5; DOI:10.1158/2159-8290.CD-NB2015-136

  • News in Brief
    Studies Identify Non-Hodgkin Lymphoma Suppressor
    Cancer Discov December 1 2015 5 (12) OF6-OF6; DOI:10.1158/2159-8290.CD-NB2015-141

News in Depth

  • News in Depth
    Is PD-L1 Expression a Biomarker of Response?
    Cancer Discov December 1 2015 5 (12) 1232-1232; DOI:10.1158/2159-8290.CD-ND2015-004

Research Watch

  • Breast Cancer

    • Research Watch
      Sensitivity to HER2 Inhibition Is Modulated by Epigenetic Control of FOXOs
      Cancer Discov December 1 2015 5 (12) 1236-1236; DOI:10.1158/2159-8290.CD-RW2015-200

    • Research Watch
      Triple-Negative Breast Cancer Is Sensitive to CDK7 Inhibition
      Cancer Discov December 1 2015 5 (12) OF7-OF7; DOI:10.1158/2159-8290.CD-RW2015-190

  • Chemotherapy

    • Research Watch
      Formyl Peptide Receptor 1 Promotes Immune Responses to Chemotherapy
      Cancer Discov December 1 2015 5 (12) 1237-1237; DOI:10.1158/2159-8290.CD-RW2015-212

  • Drug Resistance

    • Research Watch
      RNA Binding Proteins Confer Resistance to DNA-Damaging Therapy
      Cancer Discov December 1 2015 5 (12) OF8-OF8; DOI:10.1158/2159-8290.CD-RW2015-208

  • Epigenetics

    • Research Watch
      Epigenetic Silencing of TH1-Type Chemokines Promotes Tumor Immune Evasion
      Cancer Discov December 1 2015 5 (12) 1237-1237; DOI:10.1158/2159-8290.CD-RW2015-209

    • Research Watch
      H3K36me3-Deficient Cancers Are Sensitive to WEE1 Kinase Inhibition
      Cancer Discov December 1 2015 5 (12) 1233-1233; DOI:10.1158/2159-8290.CD-RW2015-210

    • Research Watch
      BAP1 Loss Transforms Mesothelioma Cells in an EZH2-Dependent Manner
      Cancer Discov December 1 2015 5 (12) OF9-OF9; DOI:10.1158/2159-8290.CD-RW2015-195

  • Genomic Instability

    • Research Watch
      The Fanconi Anemia Pathway Resolves R-Loops to Prevent Genomic Instability
      Cancer Discov December 1 2015 5 (12) OF10-OF10; DOI:10.1158/2159-8290.CD-RW2015-211

  • Genomics

    • Research Watch
      Mutation Number Predicts Outcome in Juvenile Myelomonocytic Leukemia
      Cancer Discov December 1 2015 5 (12) OF11-OF11; DOI:10.1158/2159-8290.CD-RW2015-198

    • Research Watch
      Aberrant RNA Editing Is a Potential Driver in Cancer
      Cancer Discov December 1 2015 5 (12) OF12-OF12; DOI:10.1158/2159-8290.CD-RW2015-193

  • Glioblastoma

    • Research Watch
      EGFR Mutation Induces Transcriptional and Epigenetic Remodeling in GBM
      Cancer Discov December 1 2015 5 (12) OF13-OF13; DOI:10.1158/2159-8290.CD-RW2015-196

  • Glioma

    • Research Watch
      Iron Trafficking Is Essential for Glioblastoma CSC Tumorigenicity
      Cancer Discov December 1 2015 5 (12) 1236-1236; DOI:10.1158/2159-8290.CD-RW2015-199

    • Research Watch
      Repurposed Drugs Induce Autophagy-Associated Death in Glioma
      Cancer Discov December 1 2015 5 (12) OF14-OF14; DOI:10.1158/2159-8290.CD-RW2015-188

  • Immune Evasion

    • Research Watch
      Nuclear FAK Promotes Immune Evasion in Squamous Cell Carcinoma
      Cancer Discov December 1 2015 5 (12) OF15-OF15; DOI:10.1158/2159-8290.CD-RW2015-189

  • Immunotherapy

    • Research Watch
      Small Molecule Activation Enables Improved Control of CAR T-Cells
      Cancer Discov December 1 2015 5 (12) OF16-OF16; DOI:10.1158/2159-8290.CD-RW2015-191

  • Metabolism

    • Research Watch
      NRF2 Drives Serine/Glycine Biosynthesis to Promote NSCLC Tumorigenesis
      Cancer Discov December 1 2015 5 (12) OF17-OF17; DOI:10.1158/2159-8290.CD-RW2015-203

  • Metastasis

    • Research Watch
      Oxidative Stress Is a Limiting Factor for Metastasis
      Cancer Discov December 1 2015 5 (12) 1234-1234; DOI:10.1158/2159-8290.CD-RW2015-207

    • Research Watch
      TGFβ Regulates Bone Metastasis–Associated Skeletal Muscle Weakness
      Cancer Discov December 1 2015 5 (12) 1235-1235; DOI:10.1158/2159-8290.CD-RW2015-201

  • Neuroblastoma

    • Research Watch
      TERT Rearrangement Activates Telomerase in High-Risk Neuroblastoma
      Cancer Discov December 1 2015 5 (12) 1235-1235; DOI:10.1158/2159-8290.CD-RW2015-204

  • Oncogenes

    • Research Watch
      A Novel ALK Isoform Arises via Alternative Transcription Initiation
      Cancer Discov December 1 2015 5 (12) 1233-1233; DOI:10.1158/2159-8290.CD-RW2015-197

  • Pancreatic Cancer

    • Research Watch
      Alternative Activation of p38 in Infiltrating T Cells Promotes PDAC
      Cancer Discov December 1 2015 5 (12) OF18-OF18; DOI:10.1158/2159-8290.CD-RW2015-206

  • Senescence

    • Research Watch
      GATA4 Is a Critical Regulator of Senescence and Inflammation
      Cancer Discov December 1 2015 5 (12) OF19-OF19; DOI:10.1158/2159-8290.CD-RW2015-192

  • Signaling

    • Research Watch
      Erythropoietin Promotes Tumor Growth via the Alternative Receptor EPHB4
      Cancer Discov December 1 2015 5 (12) 1234-1234; DOI:10.1158/2159-8290.CD-RW2015-205

  • Targeted Therapy

    • Research Watch
      Next-Generation RAF Inhibitors Prevent Paradoxical MAPK Activation
      Cancer Discov December 1 2015 5 (12) OF20-OF20; DOI:10.1158/2159-8290.CD-RW2015-202

  • Transcriptional Regulation

    • Research Watch
      YAP/TAZ Binds to Selected Superenhancers and Controls Pol II Pause Release
      Cancer Discov December 1 2015 5 (12) OF21-OF21; DOI:10.1158/2159-8290.CD-RW2015-194

  • Acknowledgment to Reviewers

    • Acknowledgment to Reviewers
      Acknowledgment to Reviewers
      Cancer Discov December 1 2015 5 (12) 1344-1345; DOI:10.1158/2159-8290.CD-5-12-Reviewers

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Cancer Discovery: 5 (12)
December 2015
Volume 5, Issue 12
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